Nerve Dependence: From Regeneration to Cancer

Boilly, B; Faulkner, Sam; Jobling, Phillip; Hondermarck, Hubert

doi:10.1016/j.ccell.2017.02.005

Cited by 214 publications

(173 citation statements)

References 138 publications

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“…Besides VEGFα, cancer cells released NGF and neurturin can also trigger neurite outgrowth. Overall, the similarities between cancer generation and neuro‐regeneration support a nerve dependence of cancer cell growth .…”

Section: Endogenous Triggersmentioning

confidence: 86%

Profiling of how nociceptor neurons detect danger – new and old foes

et al. 2019

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The host evolves redundant mechanisms to preserve physiological processing and homeostasis. These functions range from sensing internal and external threats, creating a memory of the insult and generating reflexes, which aim to resolve inflammation. Impairment in such functioning leads to chronic inflammatory diseases. By interacting through a common language of ligands and receptors, the immune and sensory nervous systems work in concert to accomplish such protective functions. Whilst this bidirectional communication helps to protect from danger, it can contribute to disease pathophysiology. Thus, the somatosensory nervous system is anatomically positioned within primary and secondary lymphoid tissues and mucosa to modulate immunity directly. Upstream of this interplay, neurons detect danger, which prompts the release of neuropeptides initiating (i) defensive reflexes (ranging from withdrawal response to coughing) and (ii) chemotaxis, adhesion and local infiltration of immune cells. The resulting outcome of such neuro‐immune interplay is still ill‐defined, but consensual findings start to emerge and support neuropeptides not only as blockers of TH1‐mediated immunity but also as drivers of TH2 immune responses. However, the modalities detected by nociceptors revealed broader than mechanical pressure and temperature sensing and include signals as various as cytokines and pathogens to immunoglobulins and even microRNAs. Along these lines, we aggregated various dorsal root ganglion sensory neuron expression profiling datasets supporting such wide‐ranging sensing capabilities to help identifying new danger detection modalities of these cells. Thus, revealing unexpected aspects of nociceptor neuron biology might prompt the identification of novel drivers of immunity, means to resolve inflammation and strategies to safeguard homeostasis.

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Section: Endogenous Triggersmentioning

confidence: 86%

Profiling of how nociceptor neurons detect danger – new and old foes

et al. 2019

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“…piwi, vasa and nanos), and Hox genes during regenerative processes (Bakalenko et al., ; Bely & Wray, ; Novikova et al., ; Özpolat & Bely, ; Prud'homme et al., ). Furthermore, morphogens (e.g., bone morphogenetic protein) and fibroblast growth factors might be involved in nervous activation of blastema formation (Boilly, Faulkner et al., ; Satoh, Makanae, Nishimoto, & Mitogawa, ; Takeo et al., ). These approaches are opportune to investigate the triggers of the regenerative response, the pathways that control growth and patterning of the new structures, and the re‐establishment of antero‐posterior polarity in syllids and other bilateral animals.…”

Section: Discussionmentioning

confidence: 99%

“…Epimorphosis is characterized by the activity of somatic stem cells, dedifferentiation, and re‐differentiation processes, resulting in the appropriate re‐establishment of tissue polarity, structure, and form of the organism (Agata, Saito, & Nakajima, ; Alvarado & Tsonis, ; Bely & Nyberg, ; Özpolat & Bely, ). The dedifferentiation stage is represented by the formation of a blastema, a tissue that contains undifferentiated cells and acts as a growth zone (Agata et al., ; Boilly, Faulkner, Jobling, & Hondermarck, ). In contrast, blastema formation is absent in morphallaxis, and the remaining part of the body remodels drastically acquiring morphologies consistent with new positional identities or maintaining normal proportions of the body (Agata et al., ; Özpolat & Bely, ).…”

Section: Introduction: Overview Of Annelid Regenerationmentioning

confidence: 99%

Regeneration mechanisms in Syllidae (Annelida)

2018

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Syllidae is one of the most species‐rich groups within Annelida, with a wide variety of reproductive modes and different regenerative processes. Syllids have striking ability to regenerate their body anteriorly and posteriorly, which in many species is redeployed during sexual (schizogamy) and asexual (fission) reproduction. This review summarizes the available data on regeneration in syllids, covering descriptions of regenerative mechanisms in different species as well as regeneration in relation to reproductive modes. Our survey shows that posterior regeneration is widely distributed in syllids, whereas anterior regeneration is limited in most of the species, excepting those reproducing by fission. The latter reproductive mode is well known for a few species belonging to Autolytinae, Eusyllinae, and Syllinae. Patterns of fission areas have been studied in these animals. Deviations of the regular regeneration pattern or aberrant forms such as bifurcated animals or individuals with multiple heads have been reported for several species. Some of these aberrations show a deviation of the bilateral symmetry and antero‐posterior axis, which, interestingly, can also be observed in the regular branching body pattern of some species of syllids.

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“…Embryos have an absent to weak adaptive immune system, their tissues develop and mature before the adaptive immune system, and a perfect wound healing or regeneration can only occur in embryonic‐like stages (Adzick & Longaker, ; Deuchar, ; Nodder & Martin, ). The production of high levels of hyaluronate and high tissue hydration together the activation of embryonic signaling pathways, innervation and vascularization, stimulate regeneration or tumor growth (Alibardi, , ; Boilly, Faulkner, Jobling, & Hondemarck, ; Csoka & Stern, ; Nambiar et al, ; Ross & Gordon, ; Kiricuta & Simplaceanu, ). Regenerating limbs and tails of adult amphibians show that they possess a soft consistency similar to those of the embryos (Figure a–e).…”

Section: Regeneration In Vertebrates Requires the Formation Of Blastemasmentioning

confidence: 99%

Perspective: Appendage regeneration in amphibians and some reptiles derived from specific evolutionary histories

Alibardi

2018

J Exp Zool Pt B

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Some hypotheses on the evolution of regeneration in amphibians and reptiles are presented. Amphibian regeneration is derived from metamorphosis present in sarcopterygian fish and amphibians of the Devonian‐Carboniferous. The genetic ability to rebuild organs during metamorphosis was maintained in form of “regeneration” in urodele and anuran tadpoles. Amphibian regeneration may be a consequence of the transition from an aquatic to a terrestrial environment through the evolution of a developmental program for the tadpole stage and replacements of adult organs controlled by the endocrine and immune system. Following metamorphosis, the regeneration program for terrestrial anurans and amniotes was lost or modified, whereas the immune system involved in self‐integrity and microbial protection became in charge of regeneration that was replaced by scarring. Among amniotes only lizards regenerate an organ as large and complex as the tail. It is hypothesized that in Permian captorhinids and in Triassic lizards (eosuchians) a regenerative blastema evolved in relation to autotomy, a unique phenomenon present in these reptiles that enhanced survival against the larger predators of the Permian‐Mesozoic. Appendage regeneration in amphibians and lizards occurs after the migration of activated mesenchymal and epidermal cells in the wounded areas to form soft and hyaluronate‐rich blastemas. Autotomy and production of high hyaluronate levels allows high hydration and immunosuppression, favoring regeneration. It is suggested that a way for regenerative medicine to induce limb regeneration in humans is to develop medical procedures to recreate soft blastemas that can grow, a long and difficult process because it counteracts mammalian evolution toward scarring.

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Nerve Dependence: From Regeneration to Cancer

Cited by 214 publications

References 138 publications

Profiling of how nociceptor neurons detect danger – new and old foes

Profiling of how nociceptor neurons detect danger – new and old foes

Regeneration mechanisms in Syllidae (Annelida)

Perspective: Appendage regeneration in amphibians and some reptiles derived from specific evolutionary histories

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