Nerve Conduction and Neuromuscular Transmission in C57Bl/6 Mice with Genetically Determined Peripheral Neuropathy

Govbakh, Iryna; Zavodovskiy, Danylo O.; Bulgakova, N. V.; Sokolowska, Inna; Maznychenko, A. V.; Vasylenko, D. A.

doi:10.1007/s11062-019-09817-5

Cited by 3 publications

(2 citation statements)

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“…Point mutations in the PMP22 gene, as well as DNA duplication in the region of this gene, are some of the main causes of the disease development. Both of these reasons are associated with impaired peripheral myelination and, depending on the degree of damage, can lead to slow down conduction in nerve fibers, impaired mobility of the limbs and, later, to its deformation [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Stem Cell Therapy Enhances Motor Activity of Triceps Surae Muscle in Mice with Hereditary Peripheral Neuropathy

Govbakh

Кyryk

Ustymenko

et al. 2021

IJMS

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Impaired motor and sensory functions are the main features of Charcot–Marie–Tooth disease. Mesenchymal stem cell (MSCs) therapy is one of the possible treatments for this disease. It was assumed that MSCs therapy can improve the contractile properties of the triceps surae (TS) muscles in mice with hereditary peripheral neuropathy. Murine adipose-derived mesenchymal stromal cells (AD-MSCs) were obtained for transplantation into TS muscles of FVB-C-Tg(GFPU)5Nagy/J mice. Three months after AD-MSCs transplantation, animals were subjected to electrophysiological investigations. Parameters of TS muscle tension after intermittent high frequency electrical sciatic nerve stimulations were analyzed. It was found that force of TS muscle tension contraction in animals after AD-MSCs treatment was two-time higher than in untreated mice. Normalized values of force muscle contraction in different phases of electrical stimulation were 0.3 ± 0.01 vs. 0.18 ± 0.01 and 0.26 ± 0.03 vs. 0.13 ± 0.03 for treated and untreated animals, respectively. It is assumed that the two-fold increase in TS muscle strength was caused by stem cell therapy. Apparently, AD-MSCs therapy can promote nerve regeneration and partial restoration of muscle function, and thus can be a potential therapeutic agent for the treatment of peripheral neuropathies.

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Section: Introductionmentioning

confidence: 99%

“…For the purpose of research and diagnosis of CMT1A disease, neurophysiological methods are often used to determine the speed of conduction in a nerve or muscle [ 6 , 8 ], as well as various behavioral tests [ 7 , 9 ]. In addition, some researchers use gene therapy to treat CMT1A.…”

Section: Introductionmentioning

confidence: 99%