Neroendocrine Epithelial Cell System in Respiratory Organs of Air-Breathing and Teleost Fishes

Zacone, Giacome; Fasulo, Salvatore; Ainis, L.

doi:10.1016/s0074-7696(08)62160-9

Cited by 25 publications

(14 citation statements)

References 103 publications

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“…Chloride cells of the freshwater fishes are mitochondria-rich cells that resemble the chloride cells of marine teleosts. They are one of four differentiated gill cell types, the other three types being pavement cells (or respiratory cells), mucous cells and neuroepithelial cells (Bailly et al 1992;Dunel-Erb et al 1982); neuroepithelial cells have also been observed in lungfishes (Zaccone et al 1995).…”

Section: Introductionmentioning

confidence: 99%

Mitochondria-rich cells in gills and skin of an African lungfish, Protopterus annectens

Sturla

Masini

Prato

et al. 2001

Cell and Tissue Research

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We used scanning electron microscopy, the vital dye DASPEI and an antibody to the inner mitochondrial membrane to study the presence and localisation of mitochondria-rich cells in the gills and skin (opercular, dorsal and ventral) of the lungfish Protopterus annectens in its free-swimming conditions and at the beginning of aestivation. In the free-swimming period, the gills were short and thick and the pavement cells were extremely large (30-40 microns). The mitochondria-rich cells, which were distributed in the secondary and primary epithelium, occurred as two morphologically different types, i.e. elongated and oval, similar to the alpha and beta chloride cells of fresh water teleosts. In the skin, only one type of mitochondria-rich cells was found, resembling the alpha chloride cells. All the mitochondria-rich cells distributed in the gills and skin were labelled with anti Ca(2+)-ATPase serum indicating the possible uptake of Ca2+ at freshwater chloride cell level. At the start of aestivation, the skin and gills were covered by a thick layer of mucus and the epithelium of the gills was reduced. The mitochondria-rich cells were almost completely covered by the pavement cells.

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Section: Introductionmentioning

confidence: 99%

Mitochondria-rich cells in gills and skin of an African lungfish, Protopterus annectens

Sturla

Masini

Prato

et al. 2001

Cell and Tissue Research

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“…Minor cells appear to be neither morphologically nor immunologically similar to principal cells, and therefore, it is unlikely that there is a functional similarity. The minor cell, with its numerous stanniocalcin-negative dense-cored vesicles, protein-synthesizing organelles, and long interdigitating processes, shows greater similarity to a neuroendocrine or neurosecretory cell (Zaccone et al 1995). Since the probing antibody is capable of detecting a shift in molecular weight and structure of stanniocalcin after glycopeptidase-F removal of the N-linked glycomoiety during Western blotting, this would preclude the product of the minor cells from being a nonglycosylated form of stanniocalcin (Butkus et al 1987;Flik et al 1989).…”

Section: Discussionmentioning

confidence: 99%

Corpuscles of Stannius and stanniocalcin-like immunoreactivity in the white sucker ( Catostomus commersoni ): evidence for a new cell-type

Marra

Butler

Zhang

et al. 1998

Cell and Tissue Research

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The distribution of stanniocalcin immunoreactivity was examined in the corpuscles of Stannius of the white sucker (Catostomus commersoni) by using a chum salmon stanniocalcin antiserum, Western blotting, and light and electron microscopy. The white sucker possesses at least two stanniocalcin-immunoreactive corpuscles in the most posterior portions of the kidneys. Immunocytochemistry and ultrastructure revealed two cell-types in the corpuscle parenchyma, only one of which was immunoreactive. The nonimmunoreactive cells contained dense-cored vesicles and long processes that extended between the immunoreactive cells and terminated at perivascular spaces. When corpuscle extracts were subjected to electrophoresis and Western blotting, three nonreduced stanniocalcin-like immunoreactive bands (approximately 56, 61, and 64 kDa) were observed. However, in the presence of a reductant, a diffuse band migrating in the range of 28 to 32 kDa was noted. The results of this study on the white sucker demonstrate the presence of a dimeric stanniocalcin-like molecule and present evidence of a previously uncharacterized cell-type in the corpuscles of Stannius.

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“…It has been suggested that pulmonary neuroepithelial cells may be important for O 2 chemoreception in very young animals born with immature lungs (Van Lommel et al, 1999) because young animals typically have blunted carotid body O 2 reflexes (Donnelly, 2000). Neuroepithelial cells have been described in the gills and air-breathing organs of over 10 different species of fishes (Laurent, 1984; Zaccone, et al, 1992, 1995, 1997; Jonz and Nurse, 2003). …”

Section: Identification Of Putative O2 Chemoreceptor Cellsmentioning

confidence: 99%

“…Branchial neuroepithelial cells share many of the characteristic anatomical features of mammalian O 2 -sensors (glomus and pulmonary neuroepithelial cells). Like mammalian cells, some branchial neuroepithelial cells are innervated, possess a well developed Golgi complex and numerous mitochondria and dense-cored vesicles (Dunel-Erb et al, 1982; Laurent, 1984; Zaccone et al, 1995). Falck-Hillarp fluorescence (Dunel-Erb et al, 1982) and immunohistochemistry (Zaccone et al, 1995; Jonz and Nurse, 2003) have shown that the major monoamine contained within these cells is serotonin.…”

Section: Identification Of Putative O2 Chemoreceptor Cellsmentioning

confidence: 99%

Sensory innervation of the Gills: O2-sensitive chemoreceptors and mechanoreceptors

Burleson

2009

Acta Histochemica

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SummaryPhysical characteristics of water (O 2 solubility and capacitance) dictate that cardiovascular and ventilatory performance be controlled primarily by the need for oxygen uptake rather than carbon dioxide excretion, making O 2 receptors more important in fish than in terrestrial vertebrates. An understanding of the anatomy and physiology of mechanoreception and O 2 chemoreception in fishes is important, because water breathing is the primitive template upon which the forces of evolution have modified into the various cardioventilatory modalities we see in extant terrestrial species. Key to these changes are the O 2 -sensitive chemoreceptors and mechanoreceptors, their mechanisms and central pathways.

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Neroendocrine Epithelial Cell System in Respiratory Organs of Air-Breathing and Teleost Fishes

Cited by 25 publications

References 103 publications

Mitochondria-rich cells in gills and skin of an African lungfish, Protopterus annectens

Mitochondria-rich cells in gills and skin of an African lungfish, Protopterus annectens

Corpuscles of Stannius and stanniocalcin-like immunoreactivity in the white sucker ( Catostomus commersoni ): evidence for a new cell-type

Sensory innervation of the Gills: O2-sensitive chemoreceptors and mechanoreceptors

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