Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity

Singh, Shailbala; Shenoy, S.; Yang, Peiying; Nehete, Pramod N.; Fontenot, Danielle; Yang, Guojun; Newman, Robert A.; Sastry, K. Jagannadha

doi:10.1016/j.fitote.2012.10.017

Cited by 48 publications

(45 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several investigations have reported antiviral activities of many members of family Apocynaceae. Recently, oleandrin from Nerium oleander was reported for its anti‐HIV activity (Singh et al, ). In vitro assay was performed to evaluate anti‐HIV potential by infecting HIV viruses to the HeLa CD4‐LTR/β‐gal human cell lines.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

show abstract

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Various polyherbal formulations and bioactive compounds isolated from the plants have demonstrated potent antiviral activity. Singh et al .,[22] studied the effect of an aqueous extract (Anvirzel™) of the plant on HIV infectivity in human peripheral blood mononuclear cells. They have demonstrated that without any alteration in the total number of virus particles, Anvirzel™ reduced the potentiality of HIV to infect new cells.…”

Section: Antiviral Activitymentioning

confidence: 99%

Pharmacological aspects of Nerium indicum Mill: A comprehensive review

Dey

Chaudhuri

2014

Phcog Rev

View full text Add to dashboard Cite

Phytomedicine is the oldest medical practice known to man. Since the dawn of mankind, various plant resources are used to cure different diseases and also for a long and healthy life. The ancient knowledge of plant based medicine has transferred from generations to generations and accumulated as ethnopharmacological knowledge among different ethnic groups. India is the spanning bed of traditional phytomedicinal system where Ayurveda was born out of the knowledge of traditional medicine. In various other countries of South-Eastern Asia, South America, and in Arabian countries, still today, a great number of people rely primarily on phytomedicines to cure diseases. In the complementary and alternative medicinal systems, Nerium indicum is one such plant which is famed for its therapeutic efficiency in different diseases globally. In the present time, when the pharmaceutical companies are concentrating more toward the plant based traditional medicines to avoid the side-effects and resistance against synthetic drugs, N. indicum has proved its efficiency in different disease models. Therefore, this review comprehensively covers the medicinal and pharmacological activities of different parts of the plant N. indicum.

show abstract

“…A intoxicação também ocorre em humanos, tanto pela ingestão das folhas como de forma indireta, pelo consumo de carne assada em galhos usados como espetos (HUGUES et al, 2012) ou de escargots que ingeriram a planta (GECHTMAN et al, 2006 (SOTO-BLANCO et al, 2006). Além da importância toxicológica, a oleandrina também tem importância farmacológica, pois possui atividade anti-neoplásica (KUMAR et al, 2013) e potencial anti-HIV (SINGH et al, 2013).…”

unclassified

Concentrações de oleandrina nas folhas de Nerium oleander de diferentes cores da floração

et al. 2015

View full text Add to dashboard Cite

show abstract

Nerium oleander derived cardiac glycoside oleandrin is a novel inhibitor of HIV infectivity

Cited by 48 publications

References 20 publications

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Pharmacological aspects of Nerium indicum Mill: A comprehensive review

Concentrações de oleandrina nas folhas de Nerium oleander de diferentes cores da floração

Contact Info

Product

Resources

About