1992
DOI: 10.2307/1591551
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Nephrotropic Properties Demonstrated by A/Chicken/Alabama/75 (H4N8) Following Intravenous Challenge of Chickens

Abstract: Tissue tropism properties of A/chicken/Alabama/75 (H4N8) were examined after intravenous inoculation of 5-week-old specific-pathogen-free chickens. From 14 clinically normal chickens euthanatized on days 1-20 postinoculation, the frequencies of virus recovery were highest for cloacal swabs (86%), bursal swabs (64%), and kidney tissues (64%) and lowest for tracheal swabs (14%), thymus tissues (14%), bone-marrow swabs (7%), and brain tissues (0%). Evidence that the high frequency of virus recovery from kidney ti… Show more

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Cited by 15 publications
(6 citation statements)
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“…Avian influenza H5 viruses, including H5N2 and H5N3, can cause severe outbreaks of disease in poultry (35), and the virulence of avian influenza viruses toward poultry in vivo does not depend on the HA0 cleavage site, although the extent of mortality does (1,19,23,35,41,43,46,47). Our present results in primary cultured CEF might correspond to the pathogenesis of avian influenza virus in vivo.…”
Section: Discussionmentioning
confidence: 51%
See 1 more Smart Citation
“…Avian influenza H5 viruses, including H5N2 and H5N3, can cause severe outbreaks of disease in poultry (35), and the virulence of avian influenza viruses toward poultry in vivo does not depend on the HA0 cleavage site, although the extent of mortality does (1,19,23,35,41,43,46,47). Our present results in primary cultured CEF might correspond to the pathogenesis of avian influenza virus in vivo.…”
Section: Discussionmentioning
confidence: 51%
“…The specificity of the HA receptor is thought to be one factor associated with the pathogenesis of H5N1 in humans; however, the pathogenesis after the virus has entered the cells is still unclear. Although avian influenza viruses are all potentially virulent in poultry (1,19,23,35,41,43,46,47), currently circulating H5N1 is highly virulent in humans, as well as in birds (5,59,63), suggesting that it can induce cell damage in mammalian airway organs. To elucidate why H5N1 influenza virus infection leads to DAD in human lungs, it is essential to clarify the difference(s) between recently emerged H5N1 viruses and previously circulating avian influenza viruses with respect to viral replication and processes leading to cell death at the molecular level.…”
mentioning
confidence: 99%
“…We recovered the viral RNA from all of the kidney samples (100%) on day 9 PI. These data indicate that H 9 N 2 has nephrotropic properties as indicated by Slemons and Swayne, 1995a,b; Slemons and Swayne, 1992a,b; Shalaby et al, 1994; Swayne and Slemons, 1994; Swayne and Slemons, 1990. Presumably, virus presentation in the kidneys had resulted from a localized infection of the respiratory tract.…”
Section: Discussionmentioning
confidence: 85%
“…Myeloid tissue damage might also occur in chickens infected with HPAI virus, considering that AI virus has been isolated from the bone marrow (Slemons and Swayne, 1992;Barnes, 1999).…”
mentioning
confidence: 99%
“…To our knowledge, haematological studies in AI have not yet been published and information available in this regard refers only to equine influenza (Allen and Frank, 1982;Kastner et al, 1999;Krumrych et al, 1999), while histological studies on AI virus infection are numerous (Slemons and Swayne, 1992;Kobayashi et al, 1996;Suarez et al, 1998;Capua et al, 1999).…”
mentioning
confidence: 99%