Nephrotoxins in Africa

Swanepoel, Charles R.; Naicker, Saraladevi; Moosa, Rafique; Katz, Ivor; Suleiman, Salma M.; Twahir, Majid

doi:10.1007/1-4020-2586-6_31

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the rising prevalence of hypertension and diabetes and the poor control of these conditions in Ghana may contribute to the sharp increase in renal disease mortality observed in this study . Inability of patients to afford the cost of treatment and management of renal diseases and late presentation to the hospital as well as use of herbal medications prescribed by a traditional herbalist have been suggested as major causes of the rise in mortality rates . Hypertensive and diabetic patients in Ghana frequently use herbal medications, which do not work to control their sugar and blood pressure levels.…”

Section: Discussionmentioning

confidence: 88%

20 year trends in renal disease mortality in Ghana: A review of autopsies

et al. 2019

View full text Add to dashboard Cite

We observed marked increase in renal disease mortality rate during the last few years predominantly driven by chronic and infectious related renal diseases as main cause, and hypertensive heart disease and congestive heart failure as main secondary causes. Measures geared towards prevention, treatment and managing such conditions may impact on the reduction of renal disease mortality rate among Ghanaian populations.

show abstract

Section: Discussionmentioning

confidence: 88%

20 year trends in renal disease mortality in Ghana: A review of autopsies

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[2][3][4] Despite the extensive use of medicinal plants, the safety and effectiveness of their constituents are yet to be fully explored, hence, a more thorough survey is required for evaluation and standardization of herbal formulations and their components. 5 Some studies 6,7 have reported that medicinal plants contain toxins that can cause high alterations in total white blood cell count (WBC), reduction in haemocrit, haemoglobin and red blood cells (RBC), or increase in liver enzymes and total proteins as well as diseases conditions of the kidney and liver.…”

Section: Introductionmentioning

confidence: 99%

Haematological and Biochemical Examination of Pulcherrimin A isolated from Caesalpinia pulcherrima stem bark

2021

TJNPR

View full text Add to dashboard Cite

Caesalpinia pulcherrima has been utilised in the treatment of gastritis inflammation, diarrhoea dysentery, flatulence, ulcers, hepatitis, uterine dysfunction, rheumatism, haemorrhages and many other infections. The study evaluated the haematological and biochemical effects of pulcherrimin A isolated from C. pulcherrima stem bark. The compound, pulcherrimin A was administered to Wistar rats at doses of 2, 4 and 8 mg/kg body weight (bw) respectively for 28 days. The total blood count, total cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyltranspeptidase (GGT), total protein and total bilirubin were evaluated. The results showed a significant difference in white blood cell count at 2 mg/kg for female rats. Red blood cells and haemoglobin for both sexes appeared normal relative to control. The changes observed for platelets in all treated groups for both sexes were not significantly different from the control (p˃0.05). The liver enzymes for the female rats appeared normal at all treatment doses, however, the glutamyltranspeptidase in male rats significantly increased at 2 mg/kg. The triglyceride and very low-density lipoproteins significantly decreased (p<0.05) for the female rats at 4 mg/kg. Findings from this study showed that pulcherrimin A have potential beneficial effects to reduce triglycerides and could facilitate the prevention of heart and liver related diseases.

show abstract

“…For example, African folk remedies are a frequent cause of renal and hepatic damage. [1][2][3] In one study, patients admitted to South African hospitals with acute renal failure following the use of folk remedies had a 41% mortality rate. 3 It has been estimated that one-third of cases of acute renal failure in Africa are caused by folk medicines.…”

mentioning

confidence: 99%

Traditional medicine: a global perspective

Marcus

2010

Bull World Health Org

View full text Add to dashboard Cite

Nephrotoxins in Africa

Cited by 5 publications

References 17 publications

20 year trends in renal disease mortality in Ghana: A review of autopsies

20 year trends in renal disease mortality in Ghana: A review of autopsies

Haematological and Biochemical Examination of Pulcherrimin A isolated from Caesalpinia pulcherrima stem bark

Traditional medicine: a global perspective

Contact Info

Product

Resources

About