Nephrotoxicity of Sevoflurane Versus Desflurane Anesthesia in Volunteers

Effects of sevoflurane anesthesia combined with epidural block on renal function in the elderly: comparison with isoflurane

“…Therefore, inorganic fluoride produced during sevoflurane anesthesia appears to cause no renal impairment in healthy adults. With regard to compound A, anesthesia using 3% sevoflurane with a flow rate of 2 l for 8 h in healthy volunteers resulted in abnormal increases in urinary albumin, urinary glucose, and urinary excretion of glutathione Stransferase, although BUN and creatinine levels remained unchanged [13]. However, this data was not confirmed by the subsequent study [14].…”

Glutathione S-transferase as a toxicity indicator in general anesthesia: genetics and biochemical function

“…Different immunochemical tests for α-GST detection published in the 1980s and commercial enzyme-linked immunosorbent assay kits facilitated the clinical use of α-GST measurements as an indicator of hepatocellular damage. In the analyses of the renal function, α-GST is a specific marker for the proximal part of the nephron, whereas class π-GST for its distal part [7]. The π-GST fraction is present in the majority of tissues.…”

“…Disturbance of hepatocellular integrity as a result of anesthesia with halothane, enflurane, sevoflurane, desflurane, propofol, and isoflurane was studied [3][4][5]. Serum and urine GST measurements are widely used in the studies as toxicity indicator of anesthetics in the liver and in the kidney [6][7][8].…”

Einfluss von niedrigem Alkalimetallgehalt im Atemkalk auf Compound-A-Bildung während Low-flow-Narkosen mit Sevofluran

“…Eger et al sowie Goldberg et al berichteten von vorübergehender Albumin-und Enzymurie (α-GST, π-GST) nach 4-bzw. 8-stündiger Exposition gegenüber Compound A [7,8,15].Auch Higuchi et al berichteten von einer milden, vorübergehenden Proteinurie während Sevoflurannarkosen unter Low-flow-Bedingungen [16].Allerdings wurde in keiner dieser Studien Veränderung von Harnstoff und Kreatinin im Serum oder der Kreatininclearance berichtet.…”