Nephrotoxicity of amphotericin B, with emphasis on changes in tubular function

Burgess, Janis L.; Birchall, Robert

doi:10.1016/0002-9343(72)90117-9

Cited by 159 publications

(64 citation statements)

References 16 publications

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“…Amphotericin B induces RTA type 1 by increasing membrane permeability in the collecting duct. This results in backdiffusion of secreted H + ions and K + wasting, which leads to hypokalemia [92,93]. Patients with significant proteinuria (>3 g/l) seem to have a reduced risk of renal tubular toxic effects caused by amphotericin B [94], which might be related to a reduced concentration of free amphotericin B in tubular fluid.…”

Section: Amphotericin Bmentioning

confidence: 99%

Drug-induced acid-base disorders

et al. 2014

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The incidence of acid-base disorders (ABDs) is high, especially in hospitalized patients. ABDs are often indicators for severe systemic disorders. In everyday clinical practice, analysis of ABDs must be performed in a standardized manner. Highly sensitive diagnostic tools to distinguish the various ABDs include the anion gap and the serum osmolar gap. Drug-induced ABDs can be classified into five different categories in terms of their pathophysiology: (1) metabolic acidosis caused by acid overload, which may occur through accumulation of acids by endogenous (e.g., lactic acidosis by biguanides, propofol-related syndrome) or exogenous (e.g., glycol-dependant drugs, such as diazepam or salicylates) mechanisms or by decreased renal acid excretion (e.g., distal renal tubular acidosis by amphotericin B, nonsteroidal antiinflammatory drugs, vitamin D); (2) base loss: proximal renal tubular acidosis by drugs (e.g., ifosfamide, aminoglycosides, carbonic anhydrase inhibitors, antiretrovirals, oxaliplatin or cisplatin) in the context of Fanconi syndrome; (3) alkalosis resulting from acid and/or chloride loss by renal (e.g., diuretics, penicillins, aminoglycosides) or extrarenal (e.g., laxative drugs) mechanisms; (4) exogenous bicarbonate loads: milk-alkali syndrome, overshoot alkalosis after bicarbonate therapy or citrate administration; and (5) respiratory acidosis or alkalosis resulting from drug-induced depression of the respiratory center or neuromuscular impairment (e.g

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Section: Amphotericin Bmentioning

confidence: 99%

Drug-induced acid-base disorders

et al. 2014

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“…Observou-se 90% de apoptose e necrose com a concentração máxima utilizada (5,0 mg/mL), sendo que em doses menores, mínima apoptose foi relatada. Observou-se, em estudos anteriores, que o efeito tóxico foi máximo nos túbulos (hipocalemia, hipostenúria, diminuição da capacidade de excretar ácidos), mas também envolveu os glomérulos (diminuição da depuração de creatinina, com ou sem azotemia) (Burgess, Birchall, 1972;Bhathena et al, 1978;Gerkens, Branch, 1980;Heidemann et al, 1983;Sabra et al, 1990).…”

Section: Toxicidade Induzida Pela Terapia Com Abunclassified

“…A diminuição na habilidade em concentrar a urina, resultante de alterações induzidas por AB nas funções da alça de Henle, foi relatada experimentalmente (Kirsh et al, 1988) e em pacientes (Burgess, Birchall, 1972) sendo usualmente a primeira manifestação de toxicidade. A toxicidade tubular também foi detectada pela perda renal de sódio, potássio e fosfato.…”

Section: Estudos Em Humanosunclassified

Eficiência terapêutica das formulações lipídicas de anfotericina B

Filippin

Souza

2006

Rev. Bras. Cienc. Farm.

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“…There are two main classes of antifungal drugs currently employed in the treatment of avian aspergillosis, the polyenes, such amphotericin B, and azoles including itraconazole, ketoconazole, fluconazole, enilconazole, nistatin 17,29,30 . Amphotericin B is an amphoteric polyene macrolide and has poor absorption across the gastrointestinal mucosa.…”

Section: Discussionmentioning

confidence: 99%

Bir Deve Kuşu Sürüsünde Aspergillozis’in Teşhis ve Tedavisi

Içen¹,

Işik²,

Yeşilmen³

et al. 2009

Kafkas Univ Vet Fak Derg

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SummaryThis study consists of the clinical, microbiological and pathological findings, and the results of Amphoterisin B and Biostarter for supported treatment, of focal aspergillosis in a flock of ostriches. The clinical signs were listlessness, anorexia, diarrhoea, increased respiration, dyspnoea, and mucoid discharge from the nostrils. At post-mortem examination caseous nodules were observed in various organs. Histopathological examination of the lungs, air sacs and the pleural membrane showed in different sizes in different parts of necrosis in the center of the surrounding foreign body giant cells, epitheloid macrophages, lymphocytes and granulomas surrounded by a fibrous connective tissue. In treatment, Amphotericin B and Biostarter was given orally as a supported treatment. There were no sick birds after the treatment. As a conclusion, aspergillosis could be treated with amphotericin B and as a supported treatment Biostarter, especially in the early stages of the disease. Keywords: Ostrich, Struthio camelus, Aspergillosis, Amphotericin B, Biostarter Bir Deve Kuşu Sürüsünde Aspergillozis'in Teşhis ve Tedavisi ÖzetBu çalışma, deve kuşu sürüsünde gözlenen aspergillosisin klinik, mikrobiyolojik, histopatolojik bulguları ile Amphotericin B ve destekleyici amaçla Biomaya ile sağaltım sonuçlarını içermektedir. Klinik muayenede ilgisizlik, iştahsızlık, ishal, solunum sayısı artışı, dispnea ve mukoid bir burun akıntısı tespit edildi. Nekropside çeşitli iç organlarda kazeöz-nodüler odaklar görüldü. Histopatolojik muayene de ise akciğerde, hava kesesi membranlarında ve pleuranın degisik kesimlerinde farklı büyüklüklerde, merkezinde kazeifikasyon nekrozu bulunan çevresi yabancı cisim dev hücreleri, epiteiloid makrofajlar, lenfositler ve fibröz bir bağ doku ile çevrili granulomlar görüldü. Sağaltımda Amphotericin B ve destekleyici amacıyla Biomaya verildi. Sağaltımdan sonra hayvanların hiç birinde hastalık görülmedi. Sonuç olarak özelikle hastalığın ilk döneminde Amphoterisin B ve destekleyici olarak Biomaya kullanımının tedavide başarılı olabileceği kanaatine varıldı.

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Nephrotoxicity of amphotericin B, with emphasis on changes in tubular function

Cited by 159 publications

References 16 publications

Drug-induced acid-base disorders

Drug-induced acid-base disorders

Eficiência terapêutica das formulações lipídicas de anfotericina B

Bir Deve Kuşu Sürüsünde Aspergillozis’in Teşhis ve Tedavisi

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