Nephrotoxicity of Amoxicillin and Third-Generation Cephalosporins: An Updated Review

Garnier, Antoine; Drablier, Guillaume; Briet, Marie; Augusto, Jean-François

doi:10.1007/s40264-023-01316-1

Cited by 3 publications

(1 citation statement)

References 71 publications

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“…In our case, the patient developed nephrolithiasis and gallstones 4 days post-ceftriaxone cessation, echoing findings in a seven-year-old from a previous study (de Moor et al, 1999). Due to its pharmacokinetic characteristics, particularly the extended elimination half-life, ceftriaxone is recognized as a lithogenic substance (Garnier et al, 2023). It can form crystals in the urine or bile, specifically as calcium ceftriaxone (Daudon et al, 2018).…”

Section: Discussionsupporting

confidence: 82%

Ceftriaxone-induced severe hemolytic anemia, renal calculi, and cholecystolithiasis in a 3-year-old child: a case report and literature review

Tao,

Zhou,

Zheng

et al. 2024

Front. Pharmacol.

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Ceftriaxone is widely used in pediatric outpatient care for its efficacy against respiratory and digestive system infections, yet its increasing association with severe immune hemolytic reactions requires heightened vigilance from pediatricians. This report details a rare and severe case of ceftriaxone-induced severe immune hemolytic anemia (IHA), hemolytic crisis, myocardial injury, liver injury, renal calculi, and cholecystolithiasis in a previously healthy 3-year-old child. The child, treated for bronchitis, experienced sudden pallor, limb stiffness, and altered consciousness following the fifth day of ceftriaxone infusion, with hemoglobin (Hb) levels precipitously dropping to 21 g/L. Immediate cessation of ceftriaxone and the administration of oxygen therapy, blood transfusion, intravenous immunoglobulin (IVIG), and corticosteroids led to a gradual recovery. Despite initial improvements, the patient’s condition necessitated extensive hospital care due to complications including myocardial injury, liver injury, renal calculi, and cholecystolithiasis. After a 12-day hospital stay and a 3-month follow-up, the child showed complete normalization of Hb and liver function and resolution of calculi. In children, ceftriaxone infusion may trigger severe, potentially fatal, hemolytic reactions. Pediatricians must promptly recognize symptoms such as pallor, limb stiffness, and unresponsiveness, indicative of ceftriaxone-induced severe IHA, and immediately discontinue the drug. Effective management includes timely blood transfusion, respiratory support, IVIG administration, and corticosteroids when necessary, along with rigorous vital signs monitoring. Continued vigilance is imperative, even after cessation of ceftriaxone, to promptly address any residual adverse effects.

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Section: Discussionsupporting

confidence: 82%

Ceftriaxone-induced severe hemolytic anemia, renal calculi, and cholecystolithiasis in a 3-year-old child: a case report and literature review

Tao,

Zhou,

Zheng

et al. 2024

Front. Pharmacol.

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Be aware of the risks of nephrotoxicity when prescribing amoxicillin and third-generation cephalosporins

Zhuang-Yan

2024

Drugs Ther Perspect

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Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians

Hîncu,

Apetroaei,

Ștefan

et al. 2024

Pharmaceutics

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Prevention, assessment, and identification of drug–drug interactions (DDIs) represent a challenge for healthcare professionals, especially in nosocomial settings. This narrative review aims to provide a thorough assessment of the most clinically significant DDIs for antibiotics used in healthcare-associated infections. Complex poly-pharmaceutical regimens, targeting multiple pathogens or targeting one pathogen in the presence of another comorbidity, have an increased predisposition to result in life-threatening DDIs. Recognising, assessing, and limiting DDIs in nosocomial infections offers promising opportunities for improving health outcomes. The objective of this review is to provide clinicians with practical advice to prevent or mitigate DDIs, with the aim of increasing the safety and effectiveness of therapy. DDI management is of significant importance for individualising therapy according to the patient, disease status, and associated comorbidities.

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Nephrotoxicity of Amoxicillin and Third-Generation Cephalosporins: An Updated Review

Cited by 3 publications

References 71 publications

Ceftriaxone-induced severe hemolytic anemia, renal calculi, and cholecystolithiasis in a 3-year-old child: a case report and literature review

Ceftriaxone-induced severe hemolytic anemia, renal calculi, and cholecystolithiasis in a 3-year-old child: a case report and literature review

Be aware of the risks of nephrotoxicity when prescribing amoxicillin and third-generation cephalosporins

Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians

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