Nephrotoxicity in patients receiving immune checkpoint inhibitors

Chuva, Teresa

doi:10.32932/pjnh.2020.01.047

Cited by 1 publication

(4 citation statements)

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“…The kidney is thought to be one of the most important organs affected by ICPIs. Although early reports presented a lower prevalence of renal disturbances after ICPIs administration (at around 2%), newer studies show a 29% incidence which is considered to be relatively high (18)(19)(20)(21). Seethapathy et al evaluated 1016 individuals with an average age of 63 ±13 years (61% were men), with a mean serum creatinine of 0.9 ±0.4 mg/dL at baseline.…”

Section: An Overview Of Renal Injury By Icpismentioning

confidence: 99%

“…Finally, direct binding of an ICPI to its specific receptor present on normal tissues will activate complement-mediated inflammation. This condition may deteriorate lesions that are already present in healthy tissue (18) since numerous antigens present on cancer cells are also expressed on normal tissues (17).…”

Section: The Mechanisms Of Renal Toxicity Due To Icpi Treatmentmentioning

confidence: 99%

“…However, the time frame between AIN presentation and initiation of anti-cancer treatment was longer in patients with ICPI-related AIN compared to the classical AIN. AIN has been shown to occur up to 22 months after the administration of ICPIs and in some cases more than eight weeks after receiving the last immunotherapy dosage, which is in contrast to the conventional 7-10 days in classical acute tubular necrosis (ATN) (18). Another distinct feature of ICPI-associated AIN is that re-initiation of ICPIs does not consistently cause recurrence of renal damage (27).…”

Section: The Mechanisms Of Renal Toxicity Due To Icpi Treatmentmentioning

confidence: 99%

“…Another distinct feature of ICPI-associated AIN is that re-initiation of ICPIs does not consistently cause recurrence of renal damage (27). Based on a case report, AIN relapsed one month after corticosteroid discontinuation while other studies showed no further event after receiving ICPIs (18).…”

Section: The Mechanisms Of Renal Toxicity Due To Icpi Treatmentmentioning

confidence: 99%

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Immune-related adverse kidney events by immune checkpoint inhibitors; a narrative review on current studies

et al. 2021

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Chemotherapy-associated renal injury is considered one of the major concerns among nephrological and oncological practice. The use of novel anti-neoplastic therapies that target carcinomas has helped in the detection of this form of renal injury. Immune checkpoint inhibitors (ICPIs) are a group of monoclonal antibodies targeting inhibitory receptors that exist on tumor cells and T cells. ICPIs are able to suppress tumors that might have escaped from the immune surveillance. Meanwhile, although ICPIs have shown promising efficacy in cancer treatment, their immune-related side effects limit their widespread use in cancer therapy schedules. One of the major side effects limiting ICPIs’ usage is nephrotoxicity. Glomerular disease, acute interstitial nephritis (AIN), and acute tubular necrosis (ATN) are considered different infusion-related adverse events. Infiltration of eosinophils, T lymphocytes, and plasma cells, as well as interstitial inflammation and edema, leading to acute tubulointerstitial nephritis (ATIN). It is conceivable that the rupture of self-tolerance by ICPIs induces an autoimmune reaction against some specific self-antigens in the organs including kidneys. The exact nature of the antigen is unclear; however, it is possible that it is found in the renal tubular cells, as indicated by a greater frequency of ATIN in kidney biopsies. The current review paper discusses the relationship between ICPIs therapy and kidney disorders or more specifically, their possible role in renal damage along with renal toxicity profile in the setting of ICPIs treatment.

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Section: An Overview Of Renal Injury By Icpismentioning

confidence: 99%

Section: The Mechanisms Of Renal Toxicity Due To Icpi Treatmentmentioning

confidence: 99%