Nephrotoxicity after sub chronic misuse of gabapentin and the protective role of alpha-tocopherol, an experimental study
Mohammad El-Kattan,
Mahmoud Khattab,
Fatma Abdel Maksoud
et al.
Abstract:Background: In Egypt, gabapentin (GBP) misuse and abuse have been increased in the last decade after scheduling of its analogue pregabalin in 2012. Although many studies confirmed the deleterious effects of pregabalin, those of GBP are minimal. The aim of this research is to study and evaluate the nephrotoxic effects of sub chronic high dose administration of GBP and the protective effect of alpha-tocopherol. Methods: Thirty five (35) healthy male albino rats were included. They were randomly divided into; fou… Show more
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