Nephrotoxic and Ototoxic Agents

Chemical exposure and hearing loss

“…Dysfunctions at the level of the stria vascularis may result in a massive entry of aminoglycosides into the inner-ear fluid. 32 Thus, the effect of loop diuretics on the stria vascularis facilitates the toxic effects of aminoglycosides on the hair cells. Similarly, ethacrynic acid is known to interact with cisplatin to increase its ototoxic effects.…”

The use of zebrafish for assessing ototoxic and otoprotective agents

“…Unfortunately, numerous drugs used to treat life-threatening illnesses are known to damage hair cells (Walker et al, 1990;Raphael, 2002). For example, hearing impairment can result from use of chemotherapeutic agents, such as cisplatin for cancer patients, or from treatment with aminoglycoside antibiotics for patients with bacterial infections such as meningitis, encephalitis, tuberculosis, and for patients with large wounds (Stone et al, 1996;Walker et al, 1990;Peters et al, 2003;Matsui and Cotanche, 2004). Thus, there is a need to develop methods to regenerate sensory cells and to develop protective therapeutic strategies for use with ototoxic drugs.…”

The Chemical Compound PTC124 Does Not Affect Cellular Electrophysiology of Cardiac Ventricular Myocytes

“…Gentamicin has been used in preliminary clinical trials in patients with Duchenne muscular dystrophy and cystic fibrosis caused by nonsense mutations [15,16]. However, the high doses that are required, side-effects such as nephrotoxicity and ototoxicity and need for intravenous or intramuscular administration have limited its potential usefulness for treatment of human diseases [17]. Studies with the novel aminoglycosides NB30, NB54 and NB84 that exhibit significantly reduced toxicity and superior readthrough efficiency than that of gentamicin are ongoing [18][19][20].…”