Nephrotic Syndrome With Pollen Hypersensitivity

Hardwicke, J.; Soothill, J F; Squire, J. R.; Holti, G.

doi:10.1016/s0140-6736(59)91026-8

Cited by 91 publications

(51 citation statements)

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“…Failure could be explained in some cases (for example, case 3 who was studied in June 1984) by the role played by inhalant allergens either alone, as previously demonstrat ed [3]; or in association with foods, as we have recently shown [24]. The explanation for an effect of dietary ma nipulation can be manifold.…”

Section: Discussionmentioning

confidence: 90%

“…The role of hypersensitivity to environmental antigens in idiopathic nephrotic syndrome (INS) remains con troversial [1], Since 1957, there have been several isolated reports of relapses of INS following contact with respira tory antigens; because of the seasonal onset of these exacerbations, the first of these reported cases were asso ciated with pollens [2][3][4], Later, other respiratory anti gens such as mould [5], house dust [6] and wheat flour antigens [7] were incriminated. Although the number of such reported cases is small, Fontana et al [8] have documented a high incidence of atopy in INS patients.…”

Section: Introductionmentioning

confidence: 99%

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Is Adult Idiopathic Nephrotic Syndrome Food Allergy?

Laurent

Rostoker

Robeva

et al. 1987

Nephron

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To evaluate the prevalence of food hypersensitivity in idiopathic nephrotic syndrome (INS), an oligoantigenic diet was given for 10 days to 13 patients with INS who had not steadily responded to corticosteroids; 5 of these patients were corticodependent, 3 were corticoresistant and 5 had multiple relapses. A history of allergy was present in 8 cases and an increase in total serum IgE levels in 6. Sensitivity to food antigens was documented by skin tests in 5, by the radioallergosarbent test (RAST) in 5 and by the human basophil degranulation test (HBDT) in 11. At the end of the oligoantigenic diet, proteinuria was significantly reduced in the 13 patients as compared to the initial level. It decreased by more than 50% in 9 patients and disappeared completely in 5. It seems that an oligoantigenic diet is helpful in cases of INS that do not respond to corticosteroids. This argues for a role of food hypersensitivity in this disease and suggests that avoidance of specific foods on the longer term may be of benefit. This diet must be tried in INS before the initiation of immunosuppressive therapy.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Is Adult Idiopathic Nephrotic Syndrome Food Allergy?

Laurent

Rostoker

Robeva

et al. 1987

Nephron

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

“…Numerous studies have associated INS with allergy risk of clinical and immunological features (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In the 1950s through the 1970s, few anecdotal reports described patients who developed INS after allergic reactions to inhaled allergens, vaccinations, food, or insect stings (2)(3)(4)(5). Since 1970, several case-control studies revealed that elevated serum IgE and atopic diathesis were more common in children with INS than non-INS controls (9,(11)(12)(13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

“…Children with INS commonly have elevated serum levels of immunoglobulin E (IgE), which also plays a central role in allergic inflammation (11)(12)(13)(14)(15)(16). Although clinical and immunological studies have shown a possible link between allergic diseases and INS for 50 y, human epidemiologic study using a large cohort to investigate the relationship between these disorders are lacking (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Asthma is one of the most common allergic disease in childhood, affects a multitude of patients worldwide (22).…”

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Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide, population-based cohort study

et al. 2015

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Background:Although clinical and immunological studies have shown a possible link between allergy and idiopathic nephrotic syndrome (INS), the nature of the relationship remains unclear. Asthma is the most common chronic allergic airway inflammation. However, no study has used a longitudinal design with a population cohort to investigate INS in children with asthma. Methods: Using nationwide claims data from 2000 through 2007, we randomly selected 251,698 asthma cases and 1,006,791 frequency-matched controls. Incidence rates of INS and hazard ratios (HRs) were calculated. results: The INS incidence was 3.36-fold greater in the asthma cohort than in the nonasthma control (9.26 vs. 2.76 per 100,000 person-years; 95% confidence interval (CI): 2.65-4.26). The HR for INS increased for those with more asthma-related medical visits per year, from 1.49 (95% CI: 1.06-2.11) for <3 visits to 15.7 (95% CI: 11.5-21.5) for ≥6 visits (trend test, P < 0.0001). The HR for INS slightly decreased during the follow-up period, from 3.41 (95% CI: 2.66-4.38) for ≤5.5 y to 2.90 (95% CI: 1.33-6.30) for >5.5 y. conclusion: We conclude that children with asthma had an increased incidence rate of INS, and increased incidence rate correlated with asthma-related medical visits.i diopathic nephrotic syndrome (INS) is among the most common chronic kidney diseases occurring in childhood (1). Numerous studies have associated INS with allergy risk of clinical and immunological features (2-11). In the 1950s through the 1970s, few anecdotal reports described patients who developed INS after allergic reactions to inhaled allergens, vaccinations, food, or insect stings (2-5). Since 1970, several case-control studies revealed that elevated serum IgE and atopic diathesis were more common in children with INS than non-INS controls (9,(11)(12)(13)(14)(15)(16)(17). Recently, levels of T helper 2 (Th2)-associated cytokine such as interleukin (IL)-4 and IL-13 were found to be elevated in relapsing INS patients (18-21). Children with INS commonly have elevated serum levels of immunoglobulin E (IgE), which also plays a central role in allergic inflammation (11)(12)(13)(14)(15)(16). Although clinical and immunological studies have shown a possible link between allergic diseases and INS for 50 y, human epidemiologic study using a large cohort to investigate the relationship between these disorders are lacking (2-11). Asthma is one of the most common allergic disease in childhood, affects a multitude of patients worldwide (22). It is unknown whether childhood onset asthma would increase the subsequent risk of INS. Therefore, we conducted a nationwide, population-based cohort study to examine the hypothesis that asthma may have positive influence on the development of INS in children. RESULTSA total of 251,698 subjects in the asthma cohort and 1,006,791 in the nonasthma cohort were enrolled in this study (Table 1). Most (67.6%) of the subjects were aged ≤5 y. The asthma cohort had more boys (59.4%), residents of highly urbanized areas (59.8%), and white-collar pa...

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Late Recurrences of the Nephrotic Syndrome

Worthen¹

1962

Am J Dis Child

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Nephrotic Syndrome With Pollen Hypersensitivity

Cited by 91 publications

References 5 publications

Is Adult Idiopathic Nephrotic Syndrome Food Allergy?

Is Adult Idiopathic Nephrotic Syndrome Food Allergy?

Risk of idiopathic nephrotic syndrome among children with asthma: a nationwide, population-based cohort study

Late Recurrences of the Nephrotic Syndrome

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