Nephrotic syndrome in the course of type 1 diabetes mellitus and systemic lupus erythematosus with secondary antiphospholipid syndrome – diagnostic and therapeutic problems. A case-based review

Graca, Aleksandra; Suszek, Dorota; Jeleniewicz, Radosław; Majdan, Maria

doi:10.5114/reum.2020.100105

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…A study [ 22 ] has confirmed the high sensitivity and specificity of anti- β 2-GPI in female infertility patients and patients with SLE and autoimmune hemolytic anemia. It has also been reported [ 23 ] that the ACL index is overexpressed in maintenance hemodialysis patients. Another study [ 24 ] stated that LA has high diagnostic value in patients with diabetic ketoacidosis and nosocomial pneumonia.…”

Section: Discussionmentioning

confidence: 85%

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Ding

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the application value of combined detection of anti-beta 2-glycoprotein I antibody (anti-β2-GPI), anti-cardiolipin antibody (ACL), and lupus anticoagulant (LA) in the diagnosis of patients with antiphospholipid syndrome (APS). Methods. 30 APS patients in our hospital between Jan. 2020 and Jan. 2021 were chosen as the experimental group, and 30 healthy persons with normal physical examination during the same period were selected as the control group The anti-β2-GPI and ACL indexes of both groups were detected by enzyme-linked immunosorbent assay (ELISA), with the LA levels tested by modified dilute Russell’s viper venom time (dRVVT) and LA ratio calculated. The diagnostic efficacy of single detection and combined detection was analyzed by plotting the receiver operating characteristic (ROC) curve. Results. The serum indexes in the experimental group were remarkably higher than those in the control group ( P < 0.001 ). ROC curve analysis suggested that in the diagnosis of APS, the area under the ROC curve by detecting anti-β2-GPI, ACL, LA ratio alone and simultaneously were 0.517, 0.583, 0.683, and 0.817 respectively, and the combined detection of the three had remarkably higher sensitivity and specificity than those of each single detection. Conclusion. The indexes of anti-β2-GPI, ACL, and LA ratio were highly expressed in APS patients, and the combined detection of the three has high diagnostic value and can effectively screen and assist the diagnosis of APS.

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Section: Discussionmentioning

confidence: 85%

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Ding

Yang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Nephrotic Syndrome. Idiopathic nephrotic syndrome is the most common type of renal disease in children, and it is characterized by a daily loss of protein in the urine, hypoalbuminemia, and the presence of edema [129].…”

Section: Atrophic Gastritis and Inflammatory Bowel Diseasesmentioning

confidence: 99%

Type 1 Diabetes and Other Autoimmune Disorders in Children

Grasso,

Chiarelli

2024

Pediatric Diabetes

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The incidence of autoimmune disorders (AIDs) has been dramatically increasing in both children and adults over the past few years, and type 1 diabetes (T1D) is one of the diseases that has seen the highest growth. It is well-known that the dysimmune process may spread to other systems, leading to the onset of one or more AIDs in the same individual; however, the relationship between AIDs is not often recognized. The most frequently diagnosed AIDs in children and adolescents with T1D are thyroid diseases and celiac disease, but it is also important to consider the onset of the other conditions, such as juvenile idiopathic arthritis, multiple sclerosis, atrophic gastritis, inflammatory bowel diseases, and skin disorders such as vitiligo and psoriasis. This review aims to explore the overlap of T1D and other AIDs, focusing on the less common and lesser-known diseases. A better knowledge of these comorbidities may facilitate the identification of patients at risk to treat them in the preclinical period, before the onset of complications.

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“…El síndrome nefrótico (SN) puede manifestarse en diversas enfermedades autoinmunes siendo comúnmente observada en el desarrollo del lupus eritematoso sistémico (LES). 16,17 Por otro lado, en la investigación de Nandi et al, 18 se encontró que el 54,3% de los pacientes, es decir, 23 de 42, presentaron nefritis lúpica, dentro de este estudio, el síndrome nefrótico fue la segunda manifestación renal más común, observándose en 8 de los 42 pacientes. Este porcentaje es muy similar al encontrado en nuestro estudio, donde el 48,5% (correspondiente a 16 pacientes) presentó síndrome nefrótico.…”

Section: Discusión -unclassified

Presentación clínica del compromiso renal en Lupus Eritematoso Sistémico Juvenil en una cohorte de 48 pacientes

Gruezo-Realpe,

Loor Lainez,

Vivanco Jaramillo

et al. 2023

RevReumDia

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Introducción: La afección renal en el Lupus Eritematoso Sistémico juvenil se ha relacionado con índices elevados de mortalidad. Además, la presentación clínica en estos pacientes es heterogénea y condicionan al pronóstico de la enfermedad. Objetivo: Describir la presentación clínica del compromiso renal en una cohorte de pacientes con lupus eritematoso sistémico juvenil. Métodos: Se analizaron retrospectivamente las características clínicas renales de pacientes menores a 18 años en un solo centro hospitalario de la ciudad de Guayaquil entre el 2018 – 2023 con diagnóstico de LESj usando los criterios SLICC 2012 y del Colegio Americano de Reumatología. Resultados: Se incluyeron un total de 48 pacientes, con una edad promedio de 10,75 ± 2,78 años. El promedio de ingresos hospitalarios fue de 4,40 (± 2,85). El 68,8% presentó manifestaciones renales, de los cuales, las más frecuentes fueron el síndrome nefrótico (48,5%) y seguido del síndrome nefrítico con 27,3%. El hallazgo de laboratorio más común fue la proteinuria (48,4%), seguido de hematuria (36,4%). En el 90% de los casos los anticuerpos antinucleares (ANA) se encontraron positivos. La tasa de mortalidad fue del 10.4% y hubo una asociación significativa (p=0,01) con edema facial y oliguria. Conclusión: Este estudio destaca la prevalencia de manifestaciones renales, de forma particular el síndrome nefrótico en pacientes pediátricos con lupus eritematoso sistémico, subrayando la relevancia clínica y la necesidad de vigilancia temprana. La asociación significativa entre la mortalidad y síntomas como edema facial y oliguria destaca su papel como predictores de daño renal, considerando también la mayor propensión femenina.

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Nephrotic syndrome in the course of type 1 diabetes mellitus and systemic lupus erythematosus with secondary antiphospholipid syndrome – diagnostic and therapeutic problems. A case-based review

Cited by 4 publications

References 19 publications

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Application Value of Combined Detection of Anti-β2-GPI, ACL, and Lupus Anticoagulant in the Diagnosis of Patients with Antiphospholipid Syndrome

Type 1 Diabetes and Other Autoimmune Disorders in Children

Presentación clínica del compromiso renal en Lupus Eritematoso Sistémico Juvenil en una cohorte de 48 pacientes

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