Nephrotic syndrome following COVID-19 vaccination: a systematic review

Parikh, Charmy; Upadhyay, Henil; Patel, Suyog; Sundararajan, Ramaswamy; Shah, Dhairya; Anand, Ayush; Baraskar, Bhavana; Bhatt, Tulsi; Verma, Deepak; Agrawal, Shubham; Mittal, Amol; Gupta, Sanjeev

doi:10.1007/s40620-023-01710-z

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2024

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“…Kronbichler et al suggested that there is a temporal and pathogenic association between vaccination and podocytopathies, especially MCD, after the first dose and between other podocytopathies after the second dose [ 22 ]. In a recent systematic review about nephrotic syndrome following COVID-19 immunization, pathogenesis was mainly attributed to the activation of angiotensin-converting enzyme-2 receptors, which leads to podocyte effacement [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Tip Lesion Most Frequent FSGS Variant Related to COVID-19 Vaccine: Two Case Reports and Literature Review

Araújo,

Campos,

Sodré

et al. 2024

Vaccines

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Large-scale COVID-19 vaccination has been one of the most effective strategies to control the spread of the SARS-CoV-2 virus. However, several cases of glomerular injury related to the COVID-19 vaccine have been described in the literature. We report two cases of a tip lesion variant of focal segmental glomerulosclerosis (FSGS), which presented with significant proteinuria and improved after immunosuppression. In our literature review, the tip lesion variant of FSGS is currently the most frequent variant associated with vaccination against COVID-19. Prognosis is favorable and without significant alterations in the tubulointerstitial or vascular compartments. Adverse effects of vaccines need to be recognized early and will help us to understand the immune and pathological mechanisms of kidney damage.

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Section: Discussionmentioning

confidence: 99%