Nephrotic syndrome associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Renal pathology in hematopoietic cell transplantation recipients

“…4,6,22,29 Nevertheless, resolution of graft-versus-host disease and post hematopoietic cell transplant membranous glomerulonephritis with this anti-B-cell agent supports the hypothesis that B-cell alloreactivity may play a role in both of these entities. 16,35,37 Interestingly, our study also identified two patients with biopsy proven membranous glomerulonephritis after autologous hematopoietic cell transplantation. As these patients have not received foreign cells, classic graft-versus-host disease is, by definition, not possible.…”

“…[4][5][6][14][15][16][18][19][20][21][22][23][24][25][26][27][28][29] In our series, among seven patients with membranous glomerulonephritis, all five patients with allogeneic transplants had evidence of chronic graft-versushost disease, (in the non-membranous glomerulonephritis cohort, only three out of eight patients had chronic graft-versus-host disease). Importantly, we also present two patients with biopsy proven membranous glomerulonephritis after autologous hematopoietic cell transplantation.…”

“…[4][5][6][14][15][16] Although most studies in the literature have focused on glomerulonephritis in hematopoietic cell transplant recipients, tubulointerstitial and vascular pathology is not uncommon. 5 We report the pathologic findings and corresponding clinical data, treatment, and outcome in a series of consecutive renal biopsy specimens in hematopoietic cell transplantation patients from two institutions, including the first cases of membranous glomerulonephritis post autologous stem cell transplantation documented with immunofluorescence and ultrastructural studies.…”

Chronic GVHD and concurrent new-onset nephrotic syndrome in allogeneic transplant recipients. Incidence, pattern and therapeutic outcomes

“…The histologies included in our cohort are more diverse than previously reported. [6][7][8] Tubulitis histology has not been reported before in this setting. NRP occurred only in recipients of peripheral blood allografts, suggesting that the risk of NRP may be higher with this graft source.…”

Renal pathology in hematopoietic cell transplant recipients: a contemporary biopsy, nephrectomy, and autopsy series

“…[7][8][9] Numerous descriptive studies, derived from groups of kidney core biopsy specimens from hematopoietic cell transplant recipients with renal dysfunction, have characterized the most common types of glomerulonephritis in hematopoietic cell transplant patients. 8,[10][11][12][13][14][15][16][17][18] These include membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis. In addition, acute and chronic thrombotic microangiopathy, or 'transplant-associated thrombotic microangiopathy,' has been shown to occur commonly in hematopoietic cell transplant recipients, 8,14,[17][18][19][20][21][22][23][24][25] with smaller reported numbers of membranoproliferative glomerulonephritis, proliferative glomerulonephritis, ANCA-associated glomerulonephritis, and IgA nephropathy.…”