Nephrotic range proteinuria associated with focal segmental glomerulosclerosis reversed with pioglitazone therapy in a patient with Dunnigan type lipodystrophy

Sharma, Anjul; Bourey, Raymond E.; Edwards, John C.; Brink, David S.; Albert, Stewart G.

doi:10.1016/j.diabres.2020.108620

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…DN affects about one-third of all diabetics (whether they have type 1 or type 2), causing major social and economic hardships (Akhtar et al, 2020). Kidney fibrosis, clinically defined as microalbuminuria resulting from an early rise in glomerular filtration rate (GFR) is the pathogenic basis of DN (Sharma et al, 2021). Various evidences have indicated that genetic susceptibility, dyslipidemia, hyperglycemia, and hypertension are all involved in the onset and DN progression.…”

Section: Introductionmentioning

confidence: 99%

Nano-Technological Approaches for Targeting Kidney Diseases With Focus on Diabetic Nephropathy: Recent Progress, and Future Perspectives

Lin

Wang

2022

Front. Bioeng. Biotechnol.

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Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. With the rising prevalence of diabetes, the occurrence of DN is likely to hit pandemic proportions. The current treatment strategies employed for DN focus on the management of blood pressure, glycemia, and cholesterol while neglecting DN’s molecular progression mechanism. For many theranostic uses, nano-technological techniques have evolved in biomedical studies. Several nanotechnologically based theranostics have been devised that can be tagged with targeting moieties for both drug administration and/or imaging systems and are being studied to identify various clinical conditions. The molecular mechanisms involved in DN are discussed in this review to assist in understanding its onset and progression pattern. We have also discussed emerging strategies for establishing a nanomedicine-based platform for DN-targeted drug delivery to increase drug’s efficacy and safety, as well as their reported applications.

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Section: Introductionmentioning

confidence: 99%