Nephroprotective effect of date fruit extract against dichloroacetic acid exposure in adult rats

Aqueous and Methanolic Extracts of Palm Date Seeds and Fruits (Phoenix dactylifera) Protects against Diabetic Nephropathy in Type II Diabetic Rats

“…In line with agreement with El Arem et al [18] attributed the nephroprotective effect of the aqueous extracts of palm date against the renal damage induced by dichloroacetic acid to its richness in antioxidant compounds such as ferulic, caffeic and p-coumaric acids.…”

“…In consistence with this hypothesis, Mallikarjun et al [38] demonstrated that quercetin reduced the excretion of urinary albumin excretion by 40% at the 4 th week in diabetic rats. In consistence with the findings of the present study, El Arem et al [18] demonstrated that aqueous date extract (ADE) significantly improved the plasma levels of creatinine, urea and uric acid as well as kidney morphology in a rat model of DCA-induced nephropathy. Also, Al-Qarawi et al [39] reported that administration of the extracts of the flesh and pits of palm date caused significant improvement in serum creatinine and urea concentrations and the proximal tubular damage in a gentamicin-induced nephrotoxicity in rats.…”

“…The extracts of palm date fruits and seeds showed strong antioxidant properties in many in vitro studies [9,13] and in vivo studies [10,14,15]. Recently, El Arem et al [16] demonstrated the beneficial effect of aqueous palm fruit extract (ADE) against the oxidative stress and hepatotoxicity induced by trichloroacetic acid (TCA) and Saafi-Ben Salah et al [17] and El Arem et al [18] demonstrated the beneficial effect for palm date extracts against nephrotoxicity induced by dichloroacetic acid and dimethoate respectively. Moreover, we demonstrated in a recent study by our group that palm date extracts ameliorates the hepatic dysfunctions in type 2 DM [19].…”

Conjugated metabolites represent the major circulating forms ofAbelmoschus manihot in vivoand show an altered pharmacokinetic profile in renal pathology

“…There are several flavonoids such as rutin (Sadeghnia et al, 2013), naringin (Sahu et al, 2014), and herbs containing flavonoids such as date fruit (El Arem et al, 2014), Murraya paniculata (Zou et al, 2014) exhibit nephroprotective activity, these flavonoids might undergo glucuronide-sulfate conjugate modification in vivo. Our results showed that the relationship between flavonoid glucuronide-sulfate conjugates and nephroprotective activity need further studied.…”

Evaluation of Performance of Date Palm Pollen on Urea and Creatinine Levels in Adult Female Rats Exposed to Lead Acetate Intoxication

“…The lead -protein complex forming the intra-nuclear inclusion body binds in a nondiffusible form, thereby reducing its toxic effects [26] [27]. The mechanism may be relevant to man's adaptation to his chronic body burden of lead [27].Also DPP contained some antioxidants which play important role to reactive oxygen species scavenging [6] and play important role to maintain normal level of blood urea and creatinine [23].…”