Nephroprotective Effect of Cissampelos owariensis Extract on Renal Histomorphology of Wistar Rats during Exposure to Carbon Tetrachloride- induced Nephropathy

Omotoso, Dayo Rotimi; Lawal, Olayinka Simbiat; Olatomide, Oluwasegun Davies; Okojie, Itohan Grace

doi:10.9734/ajob/2019/v8i430071

Cited by 6 publications

(3 citation statements)

References 16 publications

(18 reference statements)

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“…Some documented pharmacological applications of medicinal plants include antioxidant [4], anti-inflammatory [5], hypolipidemic [6], antidiarrheal [7], anti-proliferative [8,9], antihypertensive [10], neuroprotective [11], hepatoprotective [12], nephroprotective [13,14], antidiabetic [15], anti-ulcer [16,17], gastroprotective [18,19], haematopoietic [20] and many more.…”

Section: Introductionmentioning

confidence: 99%

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Omotoso¹,

Brown²,

Okojie³

2020

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Herbal medicinal plants constitute an integral component of plant biodiversity whose application for therapeutic purposes has been a common practice since antiquity. However, studies have reported tissue pathologies following exposure to herbal medicinal plants or extracts. This study was carried out to assess the possible pathological effects of sub-acute exposure of methanol extract of Caladium bicolor on the hepatic histomorphology of experimental Wistar rats. Twenty four Wistar rats were divided into four groups A-D. Group A was administered with distilled water (2 ml/kg b.w) and groups B-D administered with 100 ml/kg, 200ml/kg and 300ml/kg b.w. of the extract respectively for twenty eight days. The bodyweight of experimental animals was recorded at regular intervals during the study period. After the treatment period, hepatic tissue was harvested, weighed and processed for histopathological study. The results showed that exposure to the extract causes significant (p<0.05) body and organ weight reduction, a significant increase in serum level of ALT and AST as well as prominent hepatic histopathological changes such as inflammation, necrosis and steatosis. Sub-acute exposure to methanol extract of C. bicolor thereby causes dose-independent hepatopathy in experimental animals. Hence, its application for therapeutic purposes needs to be re-evaluated and preferably discontinued to avoid these associated hepatic tissue pathologies.

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Section: Introductionmentioning

confidence: 99%

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Omotoso¹,

Brown²,

Okojie³

2020

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“…The medicinal value of plants has been described as a function of therapeutic properties of their constituent phytochemical compounds and this underscore the need for efficient phytochemical screening of medicinal plant extracts or herbal preparations. In several studies, GC-MS has been employed in identification, characterization and quantification of distinct phytochemical compounds present in medicinal plant extracts or herbal preparations [24][25][26][27][28] . Based on results of this study (Table 1 and Figure 1), the phytochemical screening showed that MECS contain phenolic compounds which usually have characteristic antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

Assessment of histo-reparative effect of methanolic extract of Camellia sinensis in rat model of Lead-induced testicular damage

Omotoso

Akinola

Ehiemere

2020

J. Drug Delivery Ther.

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Objective: To assess reparative effect of methanolic extract of Camellia sinensis on testicular histomorphology of male Wistar rats exposed to lead-induced testicular damage. Methods: Twenty four male Wistar rats were grouped into four A–D (n = 6). These include normal control group A (distilled water 5 ml/kg), test control group B (lead acetate 30 mg/kg), treatment group C (lead acetate 30 mg/kg + MECS 5 mg/kg) and treatment group D (lead acetate 30 mg/kg + MECS 10 mg/kg). Administrations were through oral route for a period of 60 days and body weight of study animals was recorded during days 0, 20, 40 and 60 of study. Phytochemical analysis of extract was done using GCMS. At the end of sudy, testicular tissue weight of study animals was measured followed by histopathological study. Results: The extract significantly ameliorated body weight loss and exhibited histo-reparative effect on testicular histomorphology of study animals following lead exposure. Conclusion: Methanolic extract of Camellia sinensis exhibits reparative effect against toxic effect of tissue toxicant due to its antioxidant activity. Keywords: Camellia sinensis, Lead toxicity, Testis histomorphology, Wistar rats

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“…These functions can predispose the renal tissue to exposure and possible accumulation of potential nephrotoxins that may in turn trigger nephropathic changes within the renal parenchyma. Histopathological changes that characterized nephropathy, which may result into renal functional impairment or renal failure, include epithelial necrosis, glomerular congestion, interstitial oedema and inflammation, tubular dilatation and so on [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effects of Ascorbic Acid and Allium sativum (Garlic) Ethanol Extract on Renal Parenchyma of Gentamicin-induced Nephropathic Rats

Omotoso

Olajumoke

2020

JOCAMR

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To assess ameliorative effects of Ascorbic acid (AA) and Allium sativum ethanol extract (ASEE) on renal parenchyma of gentamicin-induced nephropathic rats. Thirty Wistar rats (weighing between 180-205 g) were randomly divided into five groups (A-E). These include Group A administered with 0.9% Normal Saline (0.5 ml/kg body weight (b.w.)), Group B administered with gentamicin (GM, 200 mg/kg b.w.) intraperitoneally (i.p.), Group C administered with GM (200 mg/kg b.w.) i.p. and AA (200 mg/kg b.w.) orally, Group D administered with GM (200 mg/kg b.w.) i.p. and ASEE (200 mg/kg b.w.) orally and Group E administered with GM (200 mg/kg b.w.) i.p. and AA (200 mg/kg b.w.) orally and ASEE (200 mg/kg b.w.) orally. All administrations were done once daily for a period of ten (10) days. The body weight of study animals was recorded at the beginning and end of study period. After the study period, renal tissue of study animals was harvested, weighed, processed, stained using H & E technique. Stained sections were examined under microscope for histopathological changes within the renal parenchyma and were scored using image-J software. The results of this study showed that exposure to GM results into significant (P < 0.05) reduction in body and renal tissue weight. However, therapeutic exposure to AA and ASEE either as individual or combined treatment regimen culminated into relatively null body and renal tissue weight loss among treatment groups C-E. In addition, exposure to GM precipitates prominent histopathological changes within renal parenchyma of study animals. As observed with body and renal tissue weight changes, treatment with AA and ASEE also comparatively ameliorate GM-induced nephropathy within renal parenchyma of study animals in treatment groups. The findings of this study therefore showed that AA and ASEE exhibit ameliorative effect on the renal parenchyma of gentamicin-induced nephropathic rats either as distinct or combined treatment regimen.

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Nephroprotective Effect of Cissampelos owariensis Extract on Renal Histomorphology of Wistar Rats during Exposure to Carbon Tetrachloride- induced Nephropathy

Cited by 6 publications

References 16 publications

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Sub-acute toxicity of Caladium bicolor (Aiton) leaf extract in Wistar rats

Assessment of histo-reparative effect of methanolic extract of Camellia sinensis in rat model of Lead-induced testicular damage

Ameliorative Effects of Ascorbic Acid and Allium sativum (Garlic) Ethanol Extract on Renal Parenchyma of Gentamicin-induced Nephropathic Rats

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