Nephropathy in falciparum malaria

Sitprija, Visith

doi:10.1038/ki.1988.262

Cited by 124 publications

(95 citation statements)

References 78 publications

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“…The parasite attaches to this receptor and taken into the RBC by invagination where it then matures. This leads to alteration of RBC membrane and reduction in its deformability (Sitprija 1988). It also enhances adherence of the RBC to endothelial cells and occlusion of microcirculation in organs (Rajapurkar, 1994).…”

Section: Discussionmentioning

confidence: 99%

Plasmodium Falciparum-Induced Kidney and Liver Dysfunction in Malaria Patients in Freetown, Sierra Leone

Oyewole¹,

Senusie²,

Mansaray³

2010

Sierra Leone j. biomed. res.

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This study was undertaken to investigate the effect of Plasmodium falciparum infection on kidney and liver function parameters in malaria patients in Freetown, Sierra Leone. Blood samples taken from 64 malaria patients and 64 non-malaria volunteers at Abanita and Blue Shield Hospitals, Freetown Sierra Leone between January to April, 2009 were examined. Changes in serum biochemical parameters were analysed using normal range values as baseline. Serum bilirubin, alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations were significantly elevated in falciparum malaria patients compared to their non-malaria counterparts which is an indication of defective liver function. Most of patients with falciparum malaria also have significantly high serum concentrations of urea, creatinine, sodium and potassium showing alteration in kidney function. This study suggests that malaria parasites could be responsible for derangement of kidney and liver functions in patients and could therefore contribute to organ damage in affected individuals if not treated.

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Section: Discussionmentioning

confidence: 99%

Plasmodium Falciparum-Induced Kidney and Liver Dysfunction in Malaria Patients in Freetown, Sierra Leone

Oyewole¹,

Senusie²,

Mansaray³

2010

Sierra Leone j. biomed. res.

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“…Prevalence of acute renal failure (ARF) in malaria all over the world has been reported as 0.57% to 60% 15 . In south-east Asia there is an up surge in the overall incidence of malarial ARF and has been reported in between 13% to 17.8% 8 .ARF occurs commonly in plasmodium falciparum malaria, although its rare occurrence has been reported in P. vivax malaria 9 .…”

Section: Introductionmentioning

confidence: 99%

Profile of Acute Kidney Injury in Plasmodium Vivax Malaria

Nigam¹

2017

JMSCR

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“…Sin embargo, la proteinuria no se relacionó con el nitrógeno ureico en sangre, lo cual probablemente se explica por el estado hipercatabólico asociado con el desarrollo de la lesión renal aguda que se ha descrito en casos de malaria (47,71).…”

Section: Leucocitosunclassified

Urinalysis as a diagnostic tool in severe malaria

Barrera

Tobón-Castaño

2017

biomedica

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Recibido: 15/07/16; aceptado: 26/02/17 Contribución de los autores:Sebastián Barrera: búsqueda bibliográfica y escritura del manuscrito Alberto Tobón: búsqueda bibliográfica, revisión crítica, corrección y escritura del manuscrito Los dos autores participaron en la escritura del manuscrito. La malaria produce complicaciones y muerte especialmente en poblaciones con acceso limitado a la atención en salud. La malaria grave puede reconocerse tempranamente mediante la detección en la orina de hallazgos como la hematuria, la coluria y la proteinuria. Se hizo una revisión narrativa basada en estudios sobre malaria grave y el empleo del análisis de orina mediante la consulta de 91 publicaciones. Mediante el análisis de la orina, se pueden detectar alteraciones metabólicas y lesiones en distintos órganos. En estudios recientes en Colombia se ha confirmado su utilidad como apoyo en el diagnóstico de la disfunción renal, la disfunción hepática y la anemia asociada con hemólisis, las cuales son complicaciones frecuentes en la malaria. El examen constituye una herramienta de fácil aplicación en la consulta ambulatoria y en pacientes hospitalizados para reconocer tempranamente casos complicados, y permite la detección oportuna de diferentes lesiones en el paciente con malaria, contribuyendo así a la reducción de la morbilidad grave y la mortalidad.Palabras clave: malaria, proteinuria, hematuria.doi: https://doi.org/10.7705/biomedica.v34i2.3416 Urinalysis as a diagnostic tool in severe malariaMalaria accounts for a significant morbidity and mortality rate around the world, especially in communities with limited access to healthcare. Some clinical signs in urine, like haematuria, coluria and proteinuria, help for the early diagnosis of severe malaria cases. A narrative review was conducted by analyzing 91 publications on studies about severe malaria cases and the use of urinalysis. A urinalysis can detect metabolic disturbances and organ injury. Its diagnostic utility for frequent complications caused by malaria, such as hepatic injury, kidney dysfunction and hemolysis, has been confirmed by recent Colombian studies. This test is an easy-to-use tool in outpatient clinics and with hospitalized patients to promptly recognize complicated cases, allowing the timely identification of different lesions in patients with malaria, thus contributing to the reduction of severe morbidity and mortality. La malaria es una enfermedad que afecta principalmente a las comunidades que habitan en regiones tropicales en donde constituye un importante problema de salud pública; las poblaciones afectadas tienen, en general, un acceso limitado a la atención en salud y a los recursos diagnósticos.En 2015 se informó una incidencia de 214 millones de casos clínicos y 438.000 muertes, la mayoría en el África subsahariana (1). La malaria afecta de manera importante a los niños, grupo que representó el 16 % del total de casos en 2015 (2) y se consideró la causa de 7 % de las muertes

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Nephropathy in falciparum malaria

Cited by 124 publications

References 78 publications

Plasmodium Falciparum-Induced Kidney and Liver Dysfunction in Malaria Patients in Freetown, Sierra Leone

Plasmodium Falciparum-Induced Kidney and Liver Dysfunction in Malaria Patients in Freetown, Sierra Leone

Profile of Acute Kidney Injury in Plasmodium Vivax Malaria

Urinalysis as a diagnostic tool in severe malaria

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