Nephron Sparing Surgery for Unilateral Wilms Tumor in Children with Predisposing Syndromes: Single Center Experience Over 10 Years

Romao, Rodrigo; Salle, João L. Pippi; Shuman, Cheryl; Weksberg, Rosanna; Figueroa, Víctor; Weber, Bryce; Bägli, Darius; Farhat, Walid A.; Grant, Ronald; Gerstle, J. Ted; Lorenzo, Armando J.

doi:10.1016/j.juro.2012.02.034

Cited by 47 publications

(26 citation statements)

References 28 publications

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“…Adequate oncological outcomes have been reported with this approach [25]. NSS can safely be done after previous partial nephrectomy, further preserving renal parenchyma whereas patients are still at risk for developing WT (Fig.…”

Section: Wt In Patients With Predisposition Syndromesmentioning

confidence: 99%

Renal function in patients with Wilms tumor

Romao

Lorenzo

2016

Urologic Oncology: Seminars and Original Investigations

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Section: Wt In Patients With Predisposition Syndromesmentioning

confidence: 99%

Renal function in patients with Wilms tumor

Romao

Lorenzo

2016

Urologic Oncology: Seminars and Original Investigations

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“…To summarize, the current study found no clear advantage to nephron sparing surgery over total nephrectomy in reducing the risk of renal complications, but due to the small number of cases, further observation should be undertaken [7,8]. Special attention should be paid to patients treated with cyclophosphamide and carboplatin [16].…”

Section: Discussionmentioning

confidence: 66%

“…According to the current therapeutic protocol, the most commonly performed operating procedure is total nephrectomy. In certain circumstances it is possible to perform partial nephrectomy (nephron sparing surgery, NSS) [7,8]. Indications for this type of procedure are mainly tumors at low clinical stages, lesions localized peripherally (not in the middle), and small lesions in bilateral Wilms' tumor cases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Renal Function in Pediatric Patients After Treatment for Wilms’ Tumor

2015

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Background. Wilms' tumor is the most common kidney cancer in children. Treatment consists of pre-and post-operative chemotherapy, surgery and in some cases radiotherapy. The treatment of nephroblastomas is very effective. Hence, the population of adult patients cured of this cancer in their childhood is steadily growing, generating a need for longterm health assessment, including renal function, due to the specifications of the therapy and the location of the tumor. Objectives. The aim of the study was to evaluate nephrological complications after treatment for nephroblastoma. Material and Methods. The study group consisted of 50 children treated in the Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation at Wroclaw Medical University (Poland) from 2002 to 2012. An analysis of the patients' medical histories was carried out. The glomerular filtration rate estimated by the Schwartz formula (GFR by Schwartz), serum creatinine levels, urea and electrolyte concentrations; the results of urinalysis and blood pressure were assessed. Each of these analyses was performed at the time of diagnosis, at the end of therapy, as well as 6 months, one year and two years after its completion. Results. The study showed that, in most cases, implemented therapy had no significant impact on the deterioration of renal parameters in the two-year period following treatment for Wilms' tumor. However, the group of patients treated with cyclophosphamide and carboplatin required more careful monitoring, due to a higher risk of renal function deterioration. Conclusions. The study shows that the problem of nephrotoxicity after treatment for Wilms' tumor is more frequent than indicated in other studies; however, the deterioration of kidney function in most cases is not serious. Additional attention should be paid to patients treated with cyclophosphamide and carboplatin. Assessment of the early and late effects of the treatment is a key element in improving the quality of the patients' life (Adv Clin Exp Med 2015, 24, 3, 497-504).

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“…However, nephron sparing is also of particular interest for children with syndromic Wilms tumor, who are at risk for multiple malignancies or renal failure from other causes. Romão et al [2] found unilateral partial nephrectomy to be safe for these patients, providing both good oncologic results and preserved renal function. Preservation of renal function is also better among children with non-syndromic Wilms tumor who undergo partial nephrectomy compared with radical nephrectomy [3].…”

Section: Discussionmentioning

confidence: 99%