Nephrolithiasis and risk of hypertension: a meta-analysis of observational studies

Shi, Weifeng; Li, Yuanyuan; Ren, Yali; Yang, Yi; Li, Hua; Dong, Jing

doi:10.1186/s12882-017-0762-8

Cited by 39 publications

(29 citation statements)

References 26 publications

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“…Similar observations were made by Sarica et al, showing that children with high body mass and urolithiasis tended to have higher systolic blood pressure (34) . An association between urolithiasis and arterial hypertension was also demonstrated by Shang et al in a meta-analysis of observational studies (35) .…”

Section: Discussionsupporting

confidence: 55%

Urolithiasis in patients with normal and high body mass: a single-centre study

Sopińska¹,

Wawrzyniak²,

Jobs³

et al. 2019

PEDIATR MED RODZ

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Assessment of the correlation between high body mass and metabolic causes of urolithiasis in patients treated over a 2-year period in the Department of Paediatrics, Paediatric Nephrology and Allergology at the Military Institute of Medicine in Warsaw. Material and methods: A total of 109 children with urolithiasis, aged 9-18 years (mean: 13 years), were enrolled in the study. The patients were divided into two groups: Group I -children with normal body mass (body mass index <85 th percentile), and Group II -children with high body mass (body mass index ≥85 th percentile). Group I consisted of 74 children (33 girls and 41 boys). Group II comprised 35 children (23 girls and 12 boys). Blood serum and urine samples were collected and tested in the laboratory to determine the causes of urolithiasis. In addition, anthropometric parameters were evaluated, including body mass index, waist circumference, waist-to-hip ratio, body mass, and body height. Also, the lipid profile was examined, and arterial blood pressure was measured in the study subjects. Results: Children with high body mass were found to have statistically significantly higher serum uric acid levels [5.4 mg/dL (5.0-6.2) vs. 4.7 mg/dL (4.1-5.4); p < 0.05] and statistically significantly higher urinary uric acid excretion (determined on the basis of the uric acid/creatinine ratio in second morning urine) compared to children with normal body mass [0.3 (0.2-0.3) vs. 0.2 (0.2-0.3); p = 0.01]. There were no statistically significant differences in the excretion of other crystalloids. In addition, children with high body mass were shown to have significantly higher values of total cholesterol [167.

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Section: Discussionsupporting

confidence: 55%

Urolithiasis in patients with normal and high body mass: a single-centre study

Sopińska¹,

Wawrzyniak²,

Jobs³

et al. 2019

PEDIATR MED RODZ

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“…In the study of Kalani et al [26] 29.7% of patients with nephrolithiasis had hypertension, which is consistent with our results. Also, Shang et al [27] showed that the risk of nephrolithiasis was directly associated with hypertension incidence. In addition, it has been shown that patients with hypertension as a related factor of the metabolic syndrome are more susceptible to kidney stones [5].…”

Section: Discussionmentioning

confidence: 99%

Risk factors of kidney stone disease: a cross-sectional study in the southeast of Iran

et al. 2021

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Background The prevalence of kidney stones in the world is increasing and environmental factors seem to play a major role in this issue. The aim of the present study was to investigate the prevalence of risk factors of kidney stones in the adult population of Rafsanjan city based on the data of the Rafsanjan Cohort Study (RCS). Methods In the baseline phase of this study, 10,000 people aged 35 to 70 years are enrolled in the RCS, as one of the prospective epidemiological research studies in Iran. From this population, 9932 participants completed related demographic questionnaires as well as reported a history of diabetes mellitus, kidney stone, and hypertension diseases. The obtained data were analyzed using univariable and multivariable logistics regression. Results According to the obtained results, 46.54% of the studied population were male and 53.46% were female. The mean age of the participants was 49.94 ± 9.56 years. 2392 people accounting for 24.08% of the population had kidney stones. After adjustment of the variables, six variables of gender, WSI, no consumption of purified water, BMI, and history of hypertension and diabetes were found to be significant related factors of kidney stone disease. Conclusions Gender, hypertension, obesity, diabetes, and personal habits like alcohol consumption, opium use and, cigarette smoking are effective in the development of kidney stones. So, by identifying the susceptible patients and teaching them, the burden of the disease on society and the individual can be reduced. The results of this study are helpful to health care providers for preventive planning for kidney stone disease.

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“…Consistent with published literature, the SFs in the current study had higher BMI and incidence of HTN, HLD, DM and smoking compared NSFs of equivalent age and gender. These comorbidities are independently linked to atherosclerosis and nephrolithiasis, making them possible contributors of biomineral deposition (1)(2)(3)(4)(5)(6)(7)15,16). Increased age, HLD, male gender, and history of nephrolithiasis were significantly and independently associated with increased ectopic mineralization burden among all patients.…”

Section: Discussionmentioning

confidence: 99%

Ectopic biomineralization in kidney stone formers compared to non-stone formers

Fernandez¹,

Sherer²,

Gansky³

et al. 2020

Transl Androl Urol

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Background: Kidney stone formers (SFs) are at increased risk of stroke, myocardial infarction, and atherosclerosis of the carotid and coronary arteries. These cardiovascular and urologic pathologies can result from ectopic biomineral deposition. The objectives of this study are: (I) to evaluate risk factors for ectopic biomineralization, and (II) to characterize the overall burden of ectopic minerals in known SFs compared to non-stone formers (NSFs) matched for these risk factors.Methods: Presence and quantity of biominerals at eight anatomic locations (abdominal aorta, common iliac arteries, pelvic veins, prostate or uterus, mesentery, pancreas, and spleen) were determined in a case control study by retrospective analysis of clinical non-contrast computed tomography scans obtained from 190 SFs and 190 gender-and age-matched NSFs (renal transplant donors). Predictors of biomineralization were determined using negative binomial regression. A subgroup of 140 SFs and 140 NSFs were matched for risk factors for systemic biomineralization, and mineralization was compared between these matched SFs and NSFs using ordinal logistic regression.Results: Hypertension, hyperlipidemia, diabetes mellitus, and smoking were more common amongst SFs.Risk factors for increased systemic biomineralization included history of nephrolithiasis, male gender, older age, and history of hyperlipidemia. When controlling for these comorbidities, SFs had significantly increased biomineralization systemically and at the abdominal aorta, iliac arteries, prostate, mesentery, pancreas, and spleen compared to NSFs. Conclusions:The current study provides evidence that SFs are at increased risk of biomineralization systemically, independent of common risk factors of atherosclerosis.

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Nephrolithiasis and risk of hypertension: a meta-analysis of observational studies

Cited by 39 publications

References 26 publications

Urolithiasis in patients with normal and high body mass: a single-centre study

Urolithiasis in patients with normal and high body mass: a single-centre study

Risk factors of kidney stone disease: a cross-sectional study in the southeast of Iran

Ectopic biomineralization in kidney stone formers compared to non-stone formers

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