Nephrogenic systemic fibrosis: Possible mechanisms and imaging management strategies

Dawson, Peter

doi:10.1002/jmri.21521

Cited by 23 publications

(16 citation statements)

References 50 publications

(54 reference statements)

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“…As a precaution, the U.S. Food and Drug Administration applied a black-box warning on gadolinium-based contrast agents in 2007 (13). Due to NSF concerns, it is recommended that special considerations be taken regarding the use of gadoliniumbased contrast agents, especially for renal-compromised patients (7,14,15). The confounding factor is that it is often the renal-compromised patients who are the patient population that needs an MRA examination.…”

Section: Instructions On Receiving Creditmentioning

confidence: 99%

Non‐contrast enhanced MR angiography: Physical principles

Wheaton

Miyazaki

2012

Magnetic Resonance Imaging

138

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Noncontrast‐enhanced magnetic resonance angiography (NCE‐MRA) methods have been demonstrated in anatomies throughout the body. Previously established NCE‐MRA techniques suffered from long scan times or low sensitivity. Advances in hardware and software have made NCE‐MRA scan times clinically feasible. Recent concerns over the safety of gadolinium‐based contrast material combined with the expense of the material and its administration have generated a demand for NCE‐MRA. In response, several new NCE‐MRA methods have been developed. The physical mechanisms underlying five general classes of NCE‐MRA methods (inflow effect, flow‐dependency on cardiac phase, flow‐encoding, spin labeling, and relaxation) are explained. The original techniques of time‐of‐flight (TOF) and phase contrast MRA (PC‐MRA) are briefly introduced. New developments in NCE‐MRA, including hybrid of opposite‐contrast (HOP‐MRA), four dimensional PC‐MRA (4D Flow), cardiac‐gated 3D fast‐spin‐echo, flow‐sensitive dephasing (FSD), arterial spin labeling (ASL), and balanced steady‐state free‐precession (bSSFP) are highlighted. The primary applications, advantages, and limitations of established and emerging NCE‐MRA techniques are discussed. J. Magn. Reson. Imaging 2012;36:286–304. © 2012 Wiley Periodicals, Inc.

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Section: Instructions On Receiving Creditmentioning

confidence: 99%

Non‐contrast enhanced MR angiography: Physical principles

Wheaton

Miyazaki

2012

Magnetic Resonance Imaging

138

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“…Body cations (calcium, zinc, or iron, for instance) may alter the thermodynamic equilibrium with gadolinium and a ligand, promoting the liberation of the lanthanide ion (47). Once liberated from the chelate, it has been speculated that Gd 3ϩ is prone to form low-solubility compounds, such as Gd(OH) 3 or Gd(PO 4 ) 3 with subsequent pathological effects (23,70). In fact, both the European Medicines Agency and the American College of Radiology have categorized the various ligands into different safety classes (Table 2) despite being grounded in purely observational data.…”

Section: Types Of Gadolinium-based Contrastmentioning

confidence: 99%

Pathophysiology of gadolinium-associated systemic fibrosis

Wagner

Drel

Gorin

2016

American Journal of Physiology-Renal Physiology

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“…Three-dimensional (3D) CE MR portography has been shown to be as effective as digital subtraction angiography for assessing the portal vein (3,4). Both CT and MR contrast agents have a risk of contrast-medium-induced nephropathy and have various side effects, including rare but lethal reactions such as anaphylactic shock and nephrogenic systemic fibrosis (5)(6)(7). Consequently, these contrast agents should not be administered to patients with decreased renal function (6).…”

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confidence: 99%

Non‐contrast‐enhanced MR portography with time‐spatial labeling inversion pulses: Comparison of imaging with three‐dimensional half‐fourier fast spin‐echo and true steady‐state free‐precession sequences

Shimada

Isoda

Okada

et al. 2009

Magnetic Resonance Imaging

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Purpose:To compare and evaluate images acquired with two different MR angiography (MRA) sequences, three-dimensional (3D) half-Fourier fast spin-echo (FSE) and 3D true steady-state free-precession (SSFP) combined with two time-spatial labeling inversion pulses (T-SLIPs), for selective and non-contrast-enhanced (non-CE) visualization of the portal vein. Materials and Methods:Twenty healthy volunteers were examined using half-Fourier FSE and true SSFP sequences on a 1.5T MRI system with two T-SLIPs, one placed on the liver and thorax, and the other on the lower abdomen. For quantitative analysis, vessel-to-liver contrast (Cv-l) ratios of the main portal vein (MPV), right portal vein (RPV), and left portal vein (LPV) were measured. The quality of visualization was also evaluated. Results:In both pulse sequences, selective visualization of the portal vein was successfully conducted in all 20 volunteers. Quantitative evaluation showed significantly better Cv-l at the RPVs and LPVs in half-Fourier FSE (P Ͻ 0.0001). At the MPV, Cv-l was better in true SSFP, but was not statistically different. Visualization scores were significantly better only at branches of segments four and eight for half-Fourier FSE (P ϭ 0.001 and 0.03, respectively). Conclusion:Both 3D half-Fourier FSE and true SSFP scans with T-SLIPs enabled selective non-CE visualization of the portal vein. Half-Fourier FSE was considered appropriate for intrahepatic portal vein visualization, and true SSFP may be preferable when visualization of the MPV is required.

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Nephrogenic systemic fibrosis: Possible mechanisms and imaging management strategies

Cited by 23 publications

References 50 publications

Non‐contrast enhanced MR angiography: Physical principles

Non‐contrast enhanced MR angiography: Physical principles

Pathophysiology of gadolinium-associated systemic fibrosis

Non‐contrast‐enhanced MR portography with time‐spatial labeling inversion pulses: Comparison of imaging with three‐dimensional half‐fourier fast spin‐echo and true steady‐state free‐precession sequences

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