Nephrogenic Systemic Fibrosis and Its Impact on Abdominal Imaging

Prince, Martin R.; Zhang, Hong Lei; Prowda, Joan C.; Grossman, Marc E.; Silvers, David N.

doi:10.1148/rg.296095517

Cited by 82 publications

(41 citation statements)

References 39 publications

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“…Gadolinium-enhanced MRI can trigger nephrogenic systemic fibrosis (NSF) in patients with severe or terminally limited renal function [54]. Limited renal function is specified as the most important patient factor for the development of NSF in the guidelines of the European Society for Urogenital Radiology [55].…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Diagnosis and Treatment of Insufficient Dialysis Vascular Access

Kamper

Faizy²,

Haage³

2015

Fortschr Röntgenstr

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A wide variety of diagnostic and minimally invasive modalities is currently available to radiologists for providing sufficient medical care for dialysis patients. In addition to clinical examination, ultrasound is the first line imaging method in suspected dialysis vascular access dysfunction. The percutaneous approach is the primarily recommended therapeutic option in many cases. This article reviews the current diagnostic and therapeutic methods in dialysis vascular access insufficiency. Key Points: ??Vascular access dysfunction is often elicited by stenosed vessels, which are regularly associated with concomitant thrombosis. ??Stenoses are commonly observed in the anastomosis, vascular access vein and also in the central venous system. ??Beside the clinical examination, sonography is the diagnostic method of first choice. ??Percutaneous balloon dilatation frequently is the first treatment option. Citation Format: ??Kamper L, Faizy TD, Haage P. Diagnosis and Treatment of Insufficient Dialysis Vascular Access. Fortschr R?ntgenstr 2015; 187: 360???371

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Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Diagnosis and Treatment of Insufficient Dialysis Vascular Access

Kamper

Faizy²,

Haage³

2015

Fortschr Röntgenstr

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“…As a quantitative functional biomarker for detection and characterization of tumor, DWI is easy-to-perform and contrast-agent-free, and its innate imaging contrast is not significantly affected by exogenous contrast agents [95,96] . Therefore, DWI can be applied in patients with renal dysfunction, where contrast agents are contradicted, for repetitive monitoring after VDA treatment [97,98] .…”

Section: Diffusion-weighted Imagingmentioning

confidence: 99%

Multiparametric MRI biomarkers for measuring vascular disrupting effect on cancer

Marchal¹,

2011

WJR

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Solid malignancies have to develop their own blood supply for their aggressive growth and metastasis; a process known as tumor angiogenesis. Angiogenesis is largely involved in tumor survival, progression and spread, which are known to be significantly attributed to treatment failures. Over the past decades, efforts have been made to understand the difference between normal and tumor vessels. It has been demonstrated that tumor vasculature is structurally immature with chaotic and leaky phenotypes, which provides opportunities for developing novel anticancer strategies. Targeting tumor vasculature is not only a unique therapeutic intervention to starve neoplastic cells, but also enhances the efficacy of conventional cancer treatments. Vascular disrupting agents (VDAs) have been developed to disrupt the already existing neovasculature in actively growing tumors, cause catastrophic vascular shutdown within short time, and induce secondary tumor necrosis. VDAs are cytostatic; they can only inhibit tumor growth, but not eradicate the tumor. This novel drug mechanism has urged us to develop multiparametric imaging biomarkers to monitor early hemodynamic alterations, cellular dysfunctions and metabolic impairments before tumor dimensional changes can be detected. In this article, we review the characteristics of tumor vessels, tubulindestabilizing mechanisms of VDAs, and in vivo effects of the VDAs that have been mostly studied in preclinical studies and clinical trials. We also compare the different tumor models adopted in the preclinical studies on VDAs. Multiparametric imaging biomarkers, mainly diffusion-weighted imaging and dynamic contrast-enhanced imaging from magnetic resonance imaging, are evaluated for their potential as morphological and functional imaging biomarkers for monitoring therapeutic effects of VDAs.

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“…Up to now, the most extensively used contrast agents are Gd(III)-based complexes [67]. Although some studies show the extraordinarily high MRI relaxivities of gadolinium nanoscale metal-organic frameworks [68], the main problem with these systems is the toxicity of leached Gd(III) [69][70][71][72]. An alternative comes from the use of manganese-containing nanoparticles, which offer comparable relaxivities to gadolinium coordination complexes.…”

Section: Bioimagingmentioning

confidence: 99%