Nephrogenic rests in Wilms tumors treated with preoperative chemotherapy: The UK SIOP Wilms Tumor 2001 Trial experience

Abstract

word count:202; Manuscript word count: 3189Number of tables and figures: 6Running title:Nephrogenic Rests in Pretreated Wilms Tumors

The effect of preoperative chemotherapy on histological subtyping and staging of Wilms tumors: The United Kingdom Children's Cancer Study Group (UKCCSG) Wilms tumor trial 3 (UKW3) experience

“…12,18,22 Nephrogenic rests are often preserved after standard preoperative chemotherapy, which is a clue to the diagnosis of WT in a completely necrotic tumor. 13,23 Preoperative chemotherapy does require a more complicated staging system, but it also downstages tumors, resulting in less postoperative treatment. 14,24 In addition to bilateral and metastatic tumors which were excluded because their preoperative treatment is longer and more aggressive, anaplastic WTs were also excluded from detailed analysis because they are regarded as chemotherapy-resistant and this group was not included in other similar studies with which we compared our results.…”

Revisiting Wilms tumour surveillance in Beckwith–Wiedemann syndrome with IC2 methylation loss, reply

“…NRs are considered as benign precursors of WT. Indeed, NRs are often identified on pathological examinations of WT: in about 40% of unilateral WT and up to 93% in bilateral WT [6]. NRs are also frequently detected in the general population (up to 1% on autopsies of infants), typically by coincidence, and transformation into WT is rare, as these NR can become quiescent with age (review in ref.…”

Maintenance chemotherapy to reduce the risk of a metachronous Wilms tumor in children with bilateral nephroblastomatosis

“…1,2 These lesions are identified in 42-45% of Wilms tumors overall and in 90-94% of bilateral Wilms tumors. 3,4 Intralobar rests are associated with young age, genitourinary anomalies, and constitutional WT1 mutations. [3][4][5] Perilobar nephrogenic rests are associated with female gender, hemihypertrophy, and Beckwith-Wiedemann syndrome.…”

“…3,4 Intralobar rests are associated with young age, genitourinary anomalies, and constitutional WT1 mutations. [3][4][5] Perilobar nephrogenic rests are associated with female gender, hemihypertrophy, and Beckwith-Wiedemann syndrome. [3][4][5] Nephroblastomatosis, or the presence of multiple nephrogenic rests, increases the risk of developing a metachronous Wilms tumor.…”

“…[3][4][5] Perilobar nephrogenic rests are associated with female gender, hemihypertrophy, and Beckwith-Wiedemann syndrome. [3][4][5] Nephroblastomatosis, or the presence of multiple nephrogenic rests, increases the risk of developing a metachronous Wilms tumor. 1,2 Treatment of a second de novo Wilms tumor in patients previously treated for Wilms tumor is challenging.…”