2000
DOI: 10.1073/pnas.080499597
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Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels

Abstract: Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells. The mouse AQP3 cDNA was isolated and encodes a 292-amino acid water͞glycerol-transporting glycoprotein expressed in kidney, large airways, eye, urinary bladder, skin, and gastrointestinal tract. The mouse AQP3 gene was analyzed, and AQP3 null mice were generated by targeted gene disruption. The growth and phenotype of AQP3 null mice were grossly normal except for polyuria. AQP3 deletio… Show more

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Cited by 362 publications
(265 citation statements)
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“…In fact, AQP1 knockout mice were found to develop polyuria due to both a defective water reabsorption mechanism in the proximal tubules and a dysfunctional countercurrent mechanism in the inner medulla (26). Other renal AQPs, such as AQP2, AQP3, and AQP4, are all present in the collecting ducts and are directly involved in water reabsorption to produce the final concentrated urine (2,13,14). Very recently, Maeda et al (16) generated AQP7 knockout mice and reported on the phenotype characteristics only in the adipocytes, where AQP7 constitutes a glycerol-releasing pathway without which hypoglycemia occurs after starvation.…”
mentioning
confidence: 99%
“…In fact, AQP1 knockout mice were found to develop polyuria due to both a defective water reabsorption mechanism in the proximal tubules and a dysfunctional countercurrent mechanism in the inner medulla (26). Other renal AQPs, such as AQP2, AQP3, and AQP4, are all present in the collecting ducts and are directly involved in water reabsorption to produce the final concentrated urine (2,13,14). Very recently, Maeda et al (16) generated AQP7 knockout mice and reported on the phenotype characteristics only in the adipocytes, where AQP7 constitutes a glycerol-releasing pathway without which hypoglycemia occurs after starvation.…”
mentioning
confidence: 99%
“…Alternatively, we hypothesize that AQP3 may function as a part of the membrane osmosensing/mechanosensing system for the initial sensing of cell swelling and therefore, may "trigger" subsequent RVD events such as solute transport and cytoskeleton reconstruction. This hypothesis is supported by the fact that AQP3 is strongly expressed in many organs, such as the bladder, trachea and esophagus, and in olfactory cells [18,28,29] , where they seem to have no obvious requirements for rapid water movement but need sensitive perception of tension, shear stress and so on. Moreover, this hypothesis is supported by the recent discovery that AQP5 is actively involved in salivary gland cell RVD by coordinating with TRPV4, a volume sensitive calcium channel, to concertedly regulate cell volume under hypotonic stimulation [23] .…”
Section: Efficient Sperm Volume Regulation Is a Prerequisite For Normmentioning
confidence: 57%
“…However, genetic deletion of AQP7 and 8 in mice did not result in obvious abnormalities in sperm morphology and function [11,16,17] , Review www.nature.com/aps Chen Q et al Acta Pharmacologica Sinica npg suggesting that these AQPs are not essential for mouse sperm function or that they can be functionally substituted by other aquaporin members. After a previous study identified Aquaporin-3 (AQP3) expression in mouse testes [18] , we demonstrated that AQP3 was present in both mouse and human sperm and was located in the plasma membrane of the principle piece of fl agellum [3] ( Figure 1A). Further functional studies using AQP3 knockout mice have shown that upon exposure to physiological hypotonic stress, AQP3 mutant sperm show normal initial motility but display increased vulnerability to hypotonic cell swelling characterized by increased tail bending after entering the uterus [3] .…”
Section: Efficient Sperm Volume Regulation Is a Prerequisite For Normmentioning
confidence: 99%
“…In contrast to AQP1 null mice, countercurrent multiplication and exchange mechanisms in AQP3/AQP4 null mice are basically intact. The polyuria in AQP3 null mice results in large part from the more than three-fold reduction in P f of cortical collecting duct basolateral membrane (16). In addition, AQP2 expression is reduced in AQP3 null mice, which appears to be a maladaptive renal response seen in various forms of acquired polyuria.…”
Section: Aqps and Urinary Concentrating Functionmentioning
confidence: 97%
“…Deletion of AQP1 and/or AQP3 in mice results in marked polyuria, as seen in 24 hour urine collections (Fig. 1B) (15,16). Fig.…”
Section: Aqps and Urinary Concentrating Functionmentioning
confidence: 99%