Nephrogenic adenoma of the urinary bladder: A report of three cases and a review of the literature

Kuzaka, B; Pudełko, Paweł; Powała, Agnieszka; Górnicka, Barbara; Radziszewski, Piotr

doi:10.12659/aot.889441

Cited by 13 publications

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“…Kuzaka et al [ 46 ] reported 3 cases of nephrogenic adenoma of the urinary bladder which were treated in their hospital between February 2011 and December 2012. They stated that all of the 3 patients had undergone previous open surgery.…”

Section: Results/literature Reviewmentioning

confidence: 99%

“…The remaining two patients had nephrogenic adenoma of the bladder only. Kuzaka et al [ 46 ] also reported that recurrent nephrogenic adenomas were diagnosed in 2 patients and the time to disease relapse was 5 months and 9 months; all the nephrogenic adenomas and recurrent tumours were treated by means of transurethral resection. …”

Section: Results/literature Reviewmentioning

confidence: 99%

“…Kuzaka et al [ 46 ] concluded that even though nephrogenic adenoma is a benign metaplastic lesion of the urothelium, its recurrence rate is relatively high; hence careful and regular follow-up is necessary; endoscopic characteristics of nephrogenic adenoma are not specific and definite diagnosis must be made after histological analysis of resected specimens. …”

Section: Results/literature Reviewmentioning

confidence: 99%

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Nephrogenic Adenoma of the Urinary Bladder: A Review of the Literature

Venyo

2015

International Scholarly Research Notices

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Background. Nephrogenic adenoma of the urinary bladder (NAUB) is a rare lesion associated with nonspecific symptoms and could inadvertently be misdiagnosed. Aim. To review the literature. Methods. Various internet search engines were used. Results. NAUB is a benign tubular and papillary lesion of the bladder, is more common in men and adults, and has been associated with chronic inflammation/irritation, previous bladder surgery, diverticula, renal transplantation, and intravesical BCG; recurrences and malignant transformations have been reported. Differential diagnoses include clear cell adenocarcinoma, endocervicosis, papillary urothelial carcinoma, prostatic adenocarcinoma of bladder, and nested variant of urothelial carcinoma; most NAUBs have both surface papillary and submucosal tubular components; both the papillae and tubules tend to be lined by a single layer of mitotically inactive bland cells which have pale to clear cytoplasm. Diagnosis may be established by using immunohistochemistry (positive staining with racemase; PAX2; keratins stain positive with fibromyxoid variant), electron microscopy, DNA analysis, and cytological studies. Treatment. Endoscopic resection is the treatment but recurrences including sporadic malignant transformation have been reported. Conclusions. There is no consensus on best treatment. A multicentre study is required to identify the treatment that would reduce the recurrence rate, taking into consideration that intravesical BCG is associated with NAUB.

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Section: Results/literature Reviewmentioning

confidence: 99%

Section: Results/literature Reviewmentioning

confidence: 99%

Section: Results/literature Reviewmentioning

confidence: 99%

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Nephrogenic Adenoma of the Urinary Bladder: A Review of the Literature

Venyo

2015

International Scholarly Research Notices

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“…In 1950, the term ‘nephrogenic adenoma’ (NA) was coined in a case series of patients describing similar pathologic findings in the bladder ( 2 ). Small case series have reported NA occurring concurrently with bladder cancer ( 3 , 4 – 7 ). Though TCC may be concurrent with the findings of nephrogenic adenoma, malignant transformation of nephrogenic adenoma has only been demonstrated in a few small case series ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

“…Though TCC may be concurrent with the findings of nephrogenic adenoma, malignant transformation of nephrogenic adenoma has only been demonstrated in a few small case series ( 8 – 10 ). The predisposing factors for this lesion are poorly understood, though many studies will report prior trauma or inflammation to play a role in the development of NA such as recurrent urinary tract infections, chronic catheterization or administration of intravesical therapy ( 3 – 5 , 7 , 8 , 10 – 15 ). Given its rarity, there are very few large series to assess these concerns and no clear guidance on its management and follow-up ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Nephrogenic adenoma of the bladder: a single institution experience assessing clinical factors

Cameron

2018

Int. braz j urol.

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Introduction:Nephrogenic adenoma (NA) was first described by Davis in 1949 as a “hamartoma” of the bladder. There are many proposed predisposing factors for NA including chronic inflammation, renal transplantation, and bladder cancer. We examined our experience with NA to determine predisposing factors and determine if there was any increased risk for development of subsequent malignancy.Materials and Methods:All patients with a pathologic diagnosis of bladder NA from 2001-2013 were included. Patient history, clinical factors including possible predisposing factors for NA, and follow-up were reviewed.Results:Among 60 patients, 68% were males with an average age of 61, an average BMI of 28.7, and 60% had a smoking history. In evaluating pro-inflammatory factors, 26.7% underwent either Bacillus Calmette-Guerin or mitomycin C, 30% had recurrent urinary tract infections, and 25% had a history of catheterization. Recurrence of NA after initial resection occurred only in 14.7% of patients who underwent follow-up cystoscopy. A history of concurrent bladder cancer was seen in 41.7% of patients, but there were no cases of de novo bladder cancer diagnosed after NA.Conclusion:To the best of our knowledge, this is the largest series of patients with NA of the bladder. NA occurs in a heterogeneous population of patients, but most often with underlying inflammation. NA occurred concurrent with bladder cancer; however there were no cases of de novo bladder cancer after NA, reassuring that NA is likely a benign reactive condition.

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Histopathology and prognosis of de novo bladder tumors following solid organ transplantation

et al. 2015

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Nephrogenic adenoma of the urinary bladder: A report of three cases and a review of the literature

Abstract: Although NA is a benign metaplastic lesion of the urothelium, its recurrence rate is relatively high, thus careful and regular follow-up is necessary. Endoscopic characteristics of NA are not specific and a definite diagnosis must be made after histological analysis of resected specimens.

Cited by 13 publications

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Nephrogenic Adenoma of the Urinary Bladder: A Review of the Literature

Nephrogenic Adenoma of the Urinary Bladder: A Review of the Literature

Nephrogenic adenoma of the bladder: a single institution experience assessing clinical factors

Histopathology and prognosis of de novo bladder tumors following solid organ transplantation

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