Nephrogenic adenoma of the bladder in a chronic hemodialysis patient

Ashida, Shingo; Yamamoto, Akihiro; Oka, Nariko; Masuda, Syusaku; Yuasa, Kenji; Terao, Naotami; T, Shiozu; Nakamura, Syoichiro; Iwata, Jun

doi:10.1046/j.1442-2042.1999.06436.x

Cited by 5 publications

(2 citation statements)

References 10 publications

(29 reference statements)

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“…[1] The bladder and different urinary tract sites comprise 80% of lesions, along with the urethra, which contains 15% of lesions, the ureter, 5%, and rarely in the renal pelvis, which is about <1%. [2] The exact etiology is unknown, various speculations include: it can be a metaplastic lesion, or it can emanate from embryonic tissue, or it could be metaplasia that on occasion co-occurs with multifocal urothelial carcinoma. [3] In this case, we report the concurrence of nephrogenic adenoma originating from the embryonic Mesonephrogenic nest, indicating its congenital origin without any pre-existing cause at the meatus of penoscrotal hypospadias.…”

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confidence: 99%

Rare presentation of nephrogenic adenoma at the meatus of penoscrotal hypospadias: A case report

Razzaq,

Anwar,

Burki

et al. 2023

J Pediatr Adolesc Surg

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Introduction: Nephrogenic adenoma is a rare benign condition that arises in the urothelium however can occur anywhere along the urinary tract. Mostly it occurs in Caucasian males with a ratio of 2:1 (male/female) . The condition mostly occurs in adults however 10% children are also affected. The lesion may occur as a metaplastic response to urothelium, or it may occur congenitally due to proliferation of meta nephrogenic rest. In this report , we emphasize on its congenital origin without any pre-existing cause in a patient of penoscrotal hypospadias.

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Section: Introductionmentioning

confidence: 99%

Rare presentation of nephrogenic adenoma at the meatus of penoscrotal hypospadias: A case report

Razzaq,

Anwar,

Burki

et al. 2023

J Pediatr Adolesc Surg

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“…7 In most instances, NA is an incidental finding, but in one-third of cases, the lesions are sizable and may be seen on cystoscopic examination, causing concern for a malignancy. [10][11][12] NA can recur and recurrence rates have been reported to range from 28% to nearly 90%; however, there is no definitive proof that NA undergoes malignant transformation. [13][14][15] Predisposing factors for the development of NA include genitourinary trauma, surgery, mechanical irritation, chronic inflammation, and renal calculi.…”

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confidence: 97%

Nephrogenic Adenoma: An Update on an Innocuous but Troublesome Entity

Rahemtullah

Oliva

2006

Advances in Anatomic Pathology

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Nephrogenic adenoma (NA) is a rare benign lesion of the urothelial tract that is typically preceded by some form of genitourinary insult. The pathogenesis of NA is not entirely clear. Although generally presumed to be a metaplastic process of the urothelium, recent evidence suggests that NA may in fact be derived from detached renal tubular cells implanting along the urothelial tract in previously injured areas, at least in cases associated with a kidney transplant. On light microscopy, NA shows a variety of patterns, including tubulocystic, papillary, and much less frequently solid, that often coexist. Recognition of its characteristic patterns, and awareness of its unusual architectural and cytologic features, is key to making the diagnosis of NA and distinguishing this lesion from malignant neoplasms occurring at the same sites, in particular, clear cell carcinoma, nested or microcystic variants of urothelial carcinoma and prostatic adenocarcinoma. Although straightforward in most cases, the correct diagnosis may be difficult to make on limited tissue samples. A number of immunohistochemical markers have been studied in an attempt to characterize NA; however, to date there is no specific immunohistochemical profile to distinguish this lesion from its malignant mimickers, although PAX2, a new marker, may prove to be helpful in this regard. Clinicopathologic correlation with careful attention to morphology remains the pillar in establishing the correct diagnosis.

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