Nephrogenic adenoma of the bladder in renal transplant and non-renal transplant patients: A review of 22 cases

Tse, Vincent; Khadra, Mohamed; Eisinger, David; Mitterdorfer, Andrew; Boulas, John; Rogers, John

doi:10.1016/s0090-4295(97)00334-8

Cited by 36 publications

(35 citation statements)

References 16 publications

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“…Moreover, in contrast to clear cell carcinoma, all cases of ureteral nephrogenic metaplasia were p53 negative and showed a very low MIB-1 labeling index (Ͻ5%). These immunohistochemical findings are similar to those of Gilcrease et al (9), who compared clear cell adenocarcinoma and nephrogenic metaplasia of the urethra and bladder and found that a high MIB-1 labeling index and Nephrogenic metaplasia of the bladder may coexist with urothelial carcinoma and adenocarcinoma (5,6); raising the possibility of malignant transformation. However, there is no evidence that this metaplastic lesion has malignant potential, despite the unexpected finding of similar cytogenetic abnormalities in both nephrogenic metaplasia and urothelial carcinoma (5).…”

Section: Discussionsupporting

confidence: 89%

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Symptomatic Nephrogenic Metaplasia of Ureter: a Morphologic and Immunohistochemical Study of Four Cases

2002

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Nephrogenic metaplasia of the bladder and urethra has been the subject of extensive studies in recent years. However, information about ureteral involvement is still limited because of the rarity of the lesion. We described four cases of nephrogenic metaplasia of the ureter. They occurred in two men and two women whose ages ranged from 46 to 69 years. Three patients had stones, and one had multiple episodes of cystitis and chronic pyelonephritis. The lesions led to ureteral obstruction that in two patients was radiographically suspicious for carcinoma. Microscopically, three lesions were composed of tiny mucin-containing microcysts and medium-sized tubular structures lined by cuboidal cells that showed cytologic atypia characterized by enlarged vesicular nuclei and prominent nucleoli. However, there were no mitotic figures. Two lesions invaded the full thickness of the wall of the ureter and exhibited an infiltrative growth pattern highlighted by cytokeratin stains. The remaining two lesions were confined to the lamina propria. The cells of nephrogenic metaplasia were immunoreactive to cytokeratin 7 and AE1-AE3. They lacked reactivity for monoclonal and polyclonal CEA and p53. The MIB-1-labeling index was <5%. The cytologic atypia and infiltrative growth pattern of ureteral nephrogenic metaplasia should not be misinterpreted as evidence of malignancy. All four patients are alive and symptom free 8 months to 7 years after diagnosis.

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Section: Discussionsupporting

confidence: 89%

“…The lesion has also been reported in renal transplant recipients (6,7). The reactive and metaplastic nature of the lesion is supported by its frequent occurrence with prior trauma to the urothelium and occasional coexistence with intestinal metaplasia (cystitis glandularis) and endocervicosis (4).…”

mentioning

confidence: 97%

Symptomatic Nephrogenic Metaplasia of Ureter: a Morphologic and Immunohistochemical Study of Four Cases

2002

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“…The reactive and metaplastic nature of the lesion is supported by its frequent occurrence with prior trauma to the urothelium, such as surgery, infection, calculi, and renal transplantation [1,4]. Prune belly syndrome may increase the risk of NA, given that NA is associated with lower urinary tract changes, including dysfunctional voiding and recurrent UTI, and the need for reconstructive urologic surgery, as in our patient [5,6].…”

Section: Discussionmentioning

confidence: 68%

“…Heidenreich et al report an 80% recurrence rate in children, with peak recurrence at approximately 4 years after treatment [3]. Malignancy arising from NA has also been described in the adult literature, although no pediatric cases have been reported [4,9,10]. As a result, we recommend treatment with transurethral fulguration or resection and follow up with routine surveillance cystoscopy to confirm the absence of residual or recurrent lesions, despite the potential risk of recurrence from repeated instrumentation.…”

Section: Discussionmentioning

confidence: 89%

Recurrent nephrogenic adenoma in a 10-year-old boy with prune belly syndrome : a case presentation

et al. 2007

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Nephrogenic adenoma is a rare benign lesion of the urinary tract that is associated with a history of irritation or injury of the urothelium. Predisposing factors include infection, calculi, surgery, trauma, and renal transplantation. Nephrogenic adenoma commonly presents with lower urinary tract symptoms or hematuria. We present the case of recurrent nephrogenic adenoma in a 10-year-old boy with a history of prune belly syndrome and discuss management of this disease in the pediatric population. To our knowledge this represents the first reported case of recurrent nephrogenic adenoma associated with prune belly syndrome.

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“…The lesion was first described by Davis [6] in 1949, but Friedman and Kuhlenbeck [7] were to name it as nephrogenic adenoma considering its resemblance to primitive renal collecting tubules. The occurrence of nephrogenic adenoma after intravesical bacillus Calmette-Guérin (BCG) treatment is very rare and only few cases have been reported in the literature [1,3,8,9]. We like to present a case of nephrogenic adenoma considered to be associated with intravesical BCG treatment.…”

Section: Introductionmentioning

confidence: 98%

Nephrogenic Adenoma of the Bladder after Intravesical Bacillus Calmette-Guérin Treatment

Kilciler¹,

Tan

Özgök³

et al. 2000

Urol Int

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A 60-year-old female patient was subjected to transurethral resection of transitional cell carcinoma of the bladder and was given intravesical bacillus Calmette-Guérin treatment for 6 weeks. The control cytoscopy performed after 6 months revealed a polypoid lesion at the trigon and the lesion was resected. The pathological examination of the specimen showed no evidence of cancer but the presence of a metaplastic lesion that was nephrogenic adenoma.

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Nephrogenic adenoma of the bladder in renal transplant and non-renal transplant patients: A review of 22 cases

Cited by 36 publications

References 16 publications

Symptomatic Nephrogenic Metaplasia of Ureter: a Morphologic and Immunohistochemical Study of Four Cases

Symptomatic Nephrogenic Metaplasia of Ureter: a Morphologic and Immunohistochemical Study of Four Cases

Recurrent nephrogenic adenoma in a 10-year-old boy with prune belly syndrome : a case presentation

Nephrogenic Adenoma of the Bladder after Intravesical Bacillus Calmette-Guérin Treatment

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