Nephrogenic Adenoma

Ortiz-Rey, J.A.; Antón-Badiola, I.; Pérez-Pedrosa, A.; Peteiro-Cancelo, A.; González-Carreró, Joaquín

doi:10.1097/pai.0b013e3182444a4e

Cited by 7 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The expression of the RCC marker was less frequent (22.2%). In our series, the analyzed distal nephron markers were also often expressed: 100% of the NAs were positive for CK7 and CK19 similar to other reports,3 84.1% for E-cad and 68.9% for Ksp-cad (a higher frequency than previously reported) 12. Therefore, all of our cases have shown a multiphenotypic expression pattern, proximal and distal, and although virtually all NAs express CK7 and CK19, 2 distal nephron markers, a variety of proximal markers can be also positive.…”

Section: Discussionsupporting

confidence: 91%

“…In our series, the analyzed distal nephron markers were also often expressed: 100% of the NAs were positive for CK7 and CK19 similar to other reports, 3 84.1% for E-cad and 68.9% for Ksp-cad (a higher frequency than previously reported). 12 Therefore, all of our cases have shown a multiphenotypic expression pattern, proximal and distal, and although virtually all NAs express CK7 and CK19, 2 distal nephron markers, a variety of proximal markers can be also positive. Although a definitive conclusion about the pathogenesis of NA cannot yet be stated, this multiphenotypic expression pattern seems to support the hypothesis of a metaplastic process of pluripotential urothelial cells rather than that of the implantation of desquamated lining cells from specifically distal or proximal tubules.…”

Section: Discussionmentioning

confidence: 54%

“…A basal cell marker such as p63 is usually negative but 34betaE12 cytokeratin is positive in most of the NAs. [2][3][4]12,13 The negativity for PSA, PSAP, and NKX3.1, 26 as well as the expression of PAX8 allow a diagnosis of NA. 20 The positivity for PAX8 in NA is outstanding (100% of our cases like in other series).…”

Section: Discussionmentioning

confidence: 99%

“…3,11,12 The immunoreactivity for other markers that are expressed in the different segments of the nephron has been reported in NA with variable frequency, such as the kidneyspecific cadherin (Ksp-cad), CD10, alpha-methylacyl-CoA racemase (AMACR), or CD117/c-kit, 8,[12][13][14] but a "proximal" or "distal" nephron immunophenotype has not been definitely established for this lesion. 12 Special AT-rich sequence-binding protein 2 (SATB2) is a nuclear matrix-associated protein with roles in growth and development. It is considered as a sensitive immunohistochemical marker for the diagnosis of a colorectal origin of adenocarcinomas or to suggest osteoblastic differentiation in mesenchymal tumors.…”

mentioning

confidence: 98%

“…[8][9][10][11] In fact, immunohistochemical expression of PAX2 or PAX8, sensitive markers of renal origin, is a key for the diagnosis of NA. 3,11,12 The immunoreactivity for other markers that are expressed in the different segments of the nephron has been reported in NA with variable frequency, such as the kidneyspecific cadherin (Ksp-cad), CD10, alpha-methylacyl-CoA racemase (AMACR), or CD117/c-kit, 8,[12][13][14] but a "proximal" or "distal" nephron immunophenotype has not been definitely established for this lesion. 12 Special AT-rich sequence-binding protein 2 (SATB2) is a nuclear matrix-associated protein with roles in growth and development.…”

mentioning

confidence: 98%

See 4 more Smart Citations

SATB2 as a Marker of the Proximal Nephron: Expression in Nephrogenic Adenoma and Correlation With Other Renal Tubular Markers

Ortiz-Rey¹,

Álvarez-Sarria²,

Conde-Ferreirós³

et al. 2023

Applied Immunohistochemistry &Amp; Molecular Morphology

Self Cite

View full text Add to dashboard Cite

Nephrogenic adenoma (NA) is an infrequent reactive urothelial lesion. The expression of immunohistochemical renal tubular markers has been reported in NA, although a proximal or distal nephron phenotype has not been established. Special AT-rich sequence-binding protein 2 (SATB2) is a marker of a colorectal origin of adenocarcinomas, occasionally reported in renal samples. We have analyzed SATB2 expression in NA, with correlation with other tubular markers, as well as in the normal kidney. Fifty cases of NA were immunostained with PAX8, SATB2, proximal nephron markers [CD10, renal cell carcinoma (RCC) marker, alpha-methylacyl-CoA racemase (AMACR), and CD15], and distal markers (Ksp cadherin, cytokeratin 7, E-cadherin (E-cad), and cytokeratin 19). Ten normal kidney sections were stained with a double method combining SATB2 plus CD10, RCC marker, AMACR, Ksp cadherin, cytokeratin 7, or E-cad. All NA were immunoreactive for PAX8 and 57% for SATB2. Every case was positive for proximal and distal nephron markers: 100% for cytokeratins 7 and 19, 84.1% E-cad +, 81.6% AMACR +, 68.9% Ksp cadherin +, 63% CD15 +, 53.3% CD10 +, and 28.6 % RCC +. In the normal kidney, SATB2 was detected in the straight part of the proximal tubules and the thin descending loops of Henle. NA shows a multiphenotypic pattern with coexpression of both proximal and distal nephron markers, and constant expression of PAX8, cytokeratins 7 and 19. SATB2 is often positive in NA, which should be kept in mind to avoid a possible misdiagnosis of intestinal adenocarcinoma. SATB2 is a marker of the normal proximal nephron.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 98%

mentioning

confidence: 98%

See 3 more Smart Citations

SATB2 as a Marker of the Proximal Nephron: Expression in Nephrogenic Adenoma and Correlation With Other Renal Tubular Markers

Ortiz-Rey¹,

Álvarez-Sarria²,

Conde-Ferreirós³

et al. 2023

Applied Immunohistochemistry &Amp; Molecular Morphology

Self Cite

View full text Add to dashboard Cite

show abstract

Differentialdiagnose multilokulärer Blasentumoren bei jungen Patienten

Mager

Hartmann

Hüsch

et al. 2013

Urologe

View full text Add to dashboard Cite

The occurrence of malignant neoplasms of the urinary tract in patients below the age of 40 years is rare. Nevertheless, finding masses with suspicious malignant appearance in young patients should alert the examiner particularly against the background of reported cases of urothelial or urachal carcinoma in childhood or adolescence. This report presents the case of a 25-year-old male patient with recurrent urolithiasis due to cystinuria. During elective stone therapy via ureteroscopy a tumor of distinct malignant appearance was conspicuous and was immediately resected. The histopathological findings revealed the diagnosis of a nephrogenic adenoma.

show abstract

Nephrogenic adenoma of the urinary tract: clinical, histological, and immunohistochemical characteristics

et al. 2013

View full text Add to dashboard Cite

Nephrogenic adenoma is a benign condition of the urinary tract resulting from the displacement and seeding of renal tubular cells from the renal pelvis to the urethra. A retrospective series of 134 cases collected from four hospitals in three different countries was analyzed in this study. Recorded clinical data included age and sex, topography, urological antecedents, coexistent lesions, and follow-up. Cytonuclear and architectural features were reviewed, and PAX-8, p63, PSMA, S100A1, CEA, EMA, CD117, cannabinoid receptor CB1, AMACR, E-cadherin, and CD10 antibodies were included in an immunohistochemical panel. Males predominated (105 M/29 F) with an average age of 66 years (range, 14-96). Urothelial carcinoma was the most frequent clinical antecedent (43.2 %) and also the most common coexisting lesion (14 %). Tubular architecture was the most frequent pattern detected (40 %) although most cases showed a mixed pattern (45.5 %). Deep infiltrative growth into the muscularis propria occurred in two cases. EMA and PAX-8 were expressed in 100 % of nephrogenic adenomas, while E-cadherin reactivity was observed in 66.6 % of cases, cannabinoid receptor CB1 in 25 %, CD10 in 13.6 %, CD117 in 4.1 %, and AMACR in 2.7 %. For the rest of the antigens, no reactivity was found. The average time lapse between the pathological antecedent and the discovery of a nephrogenic adenoma was 32 months. We conclude that nephrogenic adenoma displays a broad spectrum of histological features that may mimic malignancy. In our experience, CB1 immunostaining adds a further argument in favor of a renal origin of this lesion. The combination of PAX-8+, p63-, and EMA + distinguishes nephrogenic adenoma from urothelial and prostate carcinoma, its most frequent malignant look-alikes.

show abstract

Nephrogenic Adenoma

Cited by 7 publications

References 31 publications

SATB2 as a Marker of the Proximal Nephron: Expression in Nephrogenic Adenoma and Correlation With Other Renal Tubular Markers

SATB2 as a Marker of the Proximal Nephron: Expression in Nephrogenic Adenoma and Correlation With Other Renal Tubular Markers

Differentialdiagnose multilokulärer Blasentumoren bei jungen Patienten

Nephrogenic adenoma of the urinary tract: clinical, histological, and immunohistochemical characteristics

Contact Info

Product

Resources

About