Nephrocalcinosis in Cretinism

Bateson, Eric M.; Chander, Subhash

doi:10.1259/0007-1285-38-452-581

Cited by 18 publications

(2 citation statements)

References 14 publications

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“…Oral supplementation with magnesium and hydrochlorothiazide resulted in decreased urinary calcium excretion and some improvement in serum magnesium levels in both subjects. While the association of severe, untreated, congenital hypothyroidism with NC has been reported previously [1,16,17], widespread neonatal screening has resulted in the detection of most patients with hypothyroidism early in life. However, owing to the lack of a uniform neonatal screening program in our country, the condition is often identified at a later age.…”

Section: Discussionmentioning

confidence: 99%

Etiology of nephrocalcinosis in northern Indian children

et al. 2007

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This retrospective survey examines the etiology of nephrocalcinosis (NC) in 40 patients (26 boys), over an 8-year period. The median age at onset of symptoms and presentation was 36 months and 72 months, respectively. Clinical features included marked failure to thrive (82.5%), polyuria (60%) and bony deformities (52.5%). The etiology of NC included distal renal tubular acidosis (RTA) in 50% patients and idiopathic hypercalciuria and hyperoxaluria in 7.5% each. Other causes were Bartter syndrome, primary hypomagnesemia with hypercalciuria, severe hypothyroidism and vitamin D excess. No cause for NC was found in 12.5% patients. Specific therapy, where possible, ameliorated the biochemical aberrations, although the extent of NC remained unchanged. At a median (range) follow up of 35 (14-240) months, glomerular filtration rate (GFR) had declined from 82.0 (42-114) ml/min per 1.73 m2 body surface area to 70.8 (21.3-126.5) ml/min per 1.73 m2 body surface area (P = 0.001). Our findings confirm that, even with limited diagnostic facilities, protocol-based evaluation permits determination of the etiology of NC in most patients.

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Section: Discussionmentioning

confidence: 99%

Etiology of nephrocalcinosis in northern Indian children

et al. 2007

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“…Lightwood (1932) Boddaert (1950) Johnson and White (1952) Naylor (1955) Jeune and Beraud (1955) Wilkins (1957) Royer, Lestradet, and Habib (1958) Jeune and Muller (1 959) ThorBn and Sterky (1959) Charlas and Slomic (1962) Schmidt (1962) Hooft and Vermassen (1962) Tumay, Bilger, and Hatemi (1962) Richardson (1962) Bohm and Santoro (1964) Bateson and Chander (1965) Hagberg and Michaelsson (1965) Dubois et al (1966) Royer, Mathieu, and Balsan (1970) Gaucher et al (1971) per ml preparation per g of body weight). One animal from each group was killed by exsanguination under light ether anaesthesia on day 35.…”

Section: Referencementioning

confidence: 99%