Nephro-oncology: a link in evolution

Lacava, Viviana; Coppolino, Giuseppe; Puntorieri, Elvira; Cernaro, Valeria; Lupica, Rosaria; Visconti, Luca; Buemi, Antoine; Santoro, Domenico; Buemi, Michele

doi:10.3109/0886022x.2015.1068514

Cited by 7 publications

(5 citation statements)

References 51 publications

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“…In other medical areas, there are already specialists devoted to the assessment and management of cancer drug toxicity. Thus, there is an International CardioOncology Society 11 and similarly, most nephrology units have staff members specialized in the assessment and treatment of the different side effects caused by anticancer drugs (such as tubular interstitial nephritis or glomerulonephritis) 12 . Among hepatologists, it would be also relevant to increase the number of specialists with a high expertise in DILI, due to the growth of liver toxicity caused by anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Anticancer drugs are the first cause of drug‐induced liver injury in a reference hospital

Pocurull,

Moreta,

Heitman

et al. 2023

Liver International

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Drug‐induced liver injury (DILI) is a challenging liver disorder for hepatologists. We aimed to assess the pattern and causes of DILI in a tertiary hospital. We registered prospectively all patients referred with suspicion of DILI from 2018 to 2023. A total of 106 patients fulfilled the diagnostic criteria (30 caused by paracetamol were excluded; total number 76). The pattern of liver injury was hepatocellular in 55 (72%). Drugs causing DILI were antineoplastic (26%), antibiotics (24%), analgesics (12%), and recreational drugs (9%). Regarding clinical outcomes, 39 (51%) required hospitalization and 7 (9%) underwent a liver transplantation or died from acute liver injury. We identified 126 additional patients with DILI due to immune check‐point inhibitors who were not referred to a liver disease specialist. Antineoplastic drugs have become the first cause of DILI in hospitals. A multidisciplinary approach and specific educational tools to increase DILI awareness are needed among different specialists.

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Section: Discussionmentioning

confidence: 99%

Anticancer drugs are the first cause of drug‐induced liver injury in a reference hospital

Pocurull,

Moreta,

Heitman

et al. 2023

Liver International

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“…Anti-cancer drugs can cause injuries to various segments of the nephron. Thus, bevacizumab and gemcitabine may cause vascular lesions, while platinum salts, methotrexate, cetuximab and vincristine expose patients to tubulo-interstitial lesions (25). RF was reported to be associated with reduced overall survival and increased mortality in cancer patients (26).…”

Section: Discussionmentioning

confidence: 99%

Renal failure in cancer patients: results from the national cancer registry of Abidjan, Côte d’Ivoire

Yao¹,

Toure²,

Coulibaly³

et al. 2017

J Nephropathol

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Background: Renal failure (RF) is a risk factor for morbidity and mortality in cancer patients. Objectives: To describe the profile of cancer patients with RF. Patients and Methods: This is a retrospective descriptive study of RF in patients enrolled in the national cancer registry of Abidjan, during the period from January 2012 to December 2015. The diagnosis of RF was confirmed based on a measured glomerular filtration rate (GFR) < 60 mL/min obtained using the Modification in Diet of Renal Disease (MDRD) formula. A comparison of patients with (n = 131) or without (n = 136) RF, followed by a logistic regression analysis, made it possible to identify the risk factors for RF. Results: The mean age was 54 ± 13.9 years in the group with RF versus 49 ± 14.8 years in the group without RF (P = 0.003). The etiologies of RF were urinary tract obstruction (41.2%), administration of platinum salts (19.8%) and water losses (12.2%). In multivariate analysis, age (P = 0.009), presence of hypertension (P = 0.02), uterine cancer (P = 0.0001) and prostate cancer (P = 0.014) were associated with the risk of RF in cancer patients. Factors such as male gender (P = 0.007), HIV infection (P = 0.021), GFR<15 mL/min (P = 0.002), and hemoglobin level <8 g/dL (P = 0.041) were associated with mortality in cancer patients with RF. Conclusions: Late diagnosis leads to renal complications with an increased risk of mortality.

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“…Thus, breast cancer and kidney disease potentially share dysregulated phosphate metabolism as a common pathophysiological determinant. Chronic kidney disease (CKD) is so strongly associated with cancer that a transdisciplinary medical specialty evolved to study a link between nephrology and oncology, onco‐nephrology (Lacava et al, 2015; Rosner et al, 2021). The prevalence of CKD at the time of cancer diagnosis was reported as 12% to 53%, and glomerular filtration was reduced in 50%–60% of cancer patients (GFR < 90 mL/min/1.73 m 2 ) (Cosmai et al, 2020), leading to recommendations for a comprehensive onco‐nephrological examination in cancer patients to evaluate disturbances in electrolytes, including phosphate.…”

Section: Onco‐nephrology and Dysregulated Phosphatementioning

confidence: 99%

Breast cancer, alcohol, and phosphate toxicity

Brown

Bigelow

Dubin

et al. 2023

J of Applied Toxicology

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Alcohol consumption is associated with an increased risk of breast cancer, even at low alcohol intake levels, but public awareness of the breast cancer risk associated with alcohol intake is low. Furthermore, the causative mechanisms underlying alcohol's association with breast cancer are unknown. The present theoretical paper uses a modified grounded theory method to review the research literature and propose that alcohol's association with breast cancer is mediated by phosphate toxicity, the accumulation of excess inorganic phosphate in body tissue. Serum levels of inorganic phosphate are regulated through a network of hormones released from the bone, kidneys, parathyroid glands, and intestines. Alcohol burdens renal function, which may disturb the regulation of inorganic phosphate, impair phosphate excretion, and increase phosphate toxicity. In addition to causing cellular dehydration, alcohol is an etiologic factor in nontraumatic rhabdomyolysis, which ruptures cell membranes and releases inorganic phosphate into the serum, leading to hyperphosphatemia. Phosphate toxicity is also associated with tumorigenesis, as high levels of inorganic phosphate within the tumor microenvironment activate cell signaling pathways and promote cancer cell growth. Furthermore, phosphate toxicity potentially links cancer and kidney disease in onco‐nephrology. Insights into the mediating role of phosphate toxicity may lead to future research and interventions that raise public health awareness of breast cancer risk and alcohol consumption.

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Nephro-oncology: a link in evolution

Cited by 7 publications

References 51 publications

Anticancer drugs are the first cause of drug‐induced liver injury in a reference hospital

Anticancer drugs are the first cause of drug‐induced liver injury in a reference hospital

Renal failure in cancer patients: results from the national cancer registry of Abidjan, Côte d’Ivoire

Breast cancer, alcohol, and phosphate toxicity

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