Nephro Defensive Efficiency of Cichorium Intybus Against Toxicity Caused by Copper Oxide Nanoparticles

Abstract

The penetration of nanotechnology into the medical world is constantly growing, and this raises concerns about its toxicity. This study aimed to illustrate the defense ability of Cichorium intybus (CI) against the nephrotoxicity induced by copper oxide nanoparticles (CuONPs) in a rat model. 32 laboratory rats were evenly distributed into 4 groups, each containing 8 animals. CON rats did not receive any dosage, whereas, CuONPs animals were dosed with copper oxide nanoparticles. As for the CuONPs + CI group, intoxicated rats were dosed with Cichorium intybus extract. Lastly, CI rats were given C.intybus extract only. The parameters of renal function, oxidative stress, and renal histological changes were measured. Animals treated with CuONPs showed negative changes in all examined parameters of kidneys compared to the CON group. However, co-administration of plant extract with NPs showed a clear improvement effect of these toxic changes. We concluded that the high dose of CuONPs causes significant kidney damage, and CI extract has a defensive effect against this toxicity. Keywords: Nephrotoxicity, nanoparticles, oxidative stress, histological changes.

Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation

“…The total RNA extraction kit from Vivantis, Malaysia, was employed for this purpose. Following the confirmation of RNA concentration and purity, the process of RT-PCR was conducted with M-MuLV reverse transcriptase (NEB#M0253) . The SYBR green PCR Master Mix (Thermo Scientific, Cat.…”

“…In addition, it has been observed that they are afflicted with specific neurodegenerative disorders . CuO-NPs toxicity causes elevation of several oxidative stress biomarkers − as well as histopathological alterations in vital organs, including the brain − and the liver. ,− The brain exhibits increased susceptibility to oxidative stress due to its elevated concentration of polyunsaturated fatty acids (PUFA) and limited presence of antioxidant enzymes in comparison to other organs inside the body . CuO-NPs possess the ability to traverse biological barriers, such as the blood-brain barrier (BBB), owing to their minuscule dimensions.…”

Hepatotoxicity Induced by Some Metal Nanoparticles In Vivo: Review

“…These particles have been exploited with unparalleled merit in various biotechnology and medical applications [2,3] due to their small size and larger surface area to volume ratio [4], in addition to their unique physical, chemical and electrical properties [5]. NPs are used in many consumer products, as paints and ceramics [6], as well as in cosmetics, which has become popular in the current era [7], in addition to being recruited as a new delivery system for drugs [8], biosensors [9], and cancer treatment [10]. The growing application of MNPs has led to an increasing release of these materials into the environment, threatening human life and other living organisms.…”

Alleviative effect of betaine against copper oxide nanoparticles-induced hepatotoxicity in adult male albino rats: histopathological, biochemical, and molecular studies

“…Exposure to CuO-NPs induces the elevation of different oxidative stress markers [16,17], raising the intracellular enzymes activities as transaminases and alkaline phosphatase (ALP), causing cellular leakage and loss of cell membrane functional integrity [18], and histopathological deviations in several organs, including the liver [9,19].…”