Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses

Weight, Christopher J.; Larson, Benjamin T.; Fergany, Amr; Gao, Tianming; Lane, Brian R.; Campbell, Steven C.; Kaouk, Jihad; Klein, Eric A.; Novick, Andrew C.

doi:10.1016/j.juro.2009.12.030

Cited by 390 publications

(258 citation statements)

References 27 publications

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“…Patients with radical nephrectomy-induced chronic renal insufficiency have a 25% increased risk of cardiac death and a 17% increased risk of death from any cause compared to patients undergoing nephron preservation surgery for cT1b tumours [2].…”

Section: Trends In the Surgical Management Of Localized Renal Massesmentioning

confidence: 99%

“…Of the 413 patients treated with BT, 166 were aged <65 years. The 10-year SM-free survival for the whole BT-treated group was 87%, which was not significantly different from that of the cohort treated with radical prostatectomy (P = 0.37), Their multivariate analysis suggested that older age (P = 0.01) and history of smoking (P < 0.001) were significant predictors for the development of an SM, whereas treatment intervention was not a significant variable.Our group have recently presented data on 76 patients under the age of 55 with localized prostate cancer treated with BT-based regimens [2]. The actuarial 8-year PSA-free survival was 96%.…”

mentioning

confidence: 99%

“…Our group have recently presented data on 76 patients under the age of 55 with localized prostate cancer treated with BT-based regimens [2]. The actuarial 8-year PSA-free survival was 96%.…”

mentioning

confidence: 99%

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Trends in the surgical management of localized renal masses

Bolton

2013

BJU International

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of the incidence of SM among 2658 patients with localized prostate cancer after definitive treatment with radical prostatectomy, EBRT or BT [8]. Of the 413 patients treated with BT, 166 were aged <65 years. The 10-year SM-free survival for the whole BT-treated group was 87%, which was not significantly different from that of the cohort treated with radical prostatectomy (P = 0.37), Their multivariate analysis suggested that older age (P = 0.01) and history of smoking (P < 0.001) were significant predictors for the development of an SM, whereas treatment intervention was not a significant variable.Our group have recently presented data on 76 patients under the age of 55 with localized prostate cancer treated with BT-based regimens [2]. The actuarial 8-year PSA-free survival was 96%. Among the 54 patients with preoperative International Index of Erectile Function (IIEF) data available, 81% were potent (IIEF score Յ11) before receiving treatment. At 4-year follow-up, 94% of these patients with IIEF data available were still potent. BT is a convenient, effective and well-tolerated treatment for low-and intermediate-risk clinically localized prostate cancer in men aged Յ60 years, which often preserves erectile function. BT may be considered one of the treatments of choice for these younger patients. after intensity-modulated radiotherapy, brachytherapy and radical prostatectomy for the treatment of prostate cancer: incidence and cause-specific survival outcomes according to the initial treatment intervention. Conflict of Interest

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Section: Trends In the Surgical Management Of Localized Renal Massesmentioning

confidence: 99%

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confidence: 99%

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Trends in the surgical management of localized renal masses

Bolton

2013

BJU International

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“…This trend has been attributed to the growing number of small renal masses incidentally detected on cross-sectional imaging performed for non-urologic conditions [3]. With this trend, treatment with partial nephrectomy (PN) has seen widespread use [4][5][6] as a means to avoid the sequelae of surgically induced chronic kidney disease associated with radical nephrectomy (RN) [7][8][9][10]. In fact, current guidelines from the American Urological Association (AUA) [11], National Comprehensive Cancer Network (NCCN) [12••], and European Association of Urology (EUA) [13••] now promote the use of PN whenever technically feasible for the treatment of small renal tumors.…”

Section: Introductionmentioning

confidence: 99%

Post Partial Nephrectomy Surveillance Imaging: an Evidence-Based Approach

Gorin

Allaf

2015

Curr Urol Rep

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To ensure the early detection of recurrent disease, all patients should undergo routine surveillance following partial nephrectomy for renal cell carcinoma. In order to optimize resource allocation and avoid unnecessary radiation exposure, the frequency and duration of surveillance should be tailored to the individual patient's risk of cancer recurrence. The evidence for surveillance after partial nephrectomy is presented reviewing the current literature on prognostic models and proposed surveillance protocols based on the timing and patterns of renal cell carcinoma recurrence. In addition, we review recent guidelines on post partial nephrectomy surveillance as well as the literature on novel imaging techniques that may aid in early disease discovery.

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“…[1] In addition, based on primarily retrospective data identifying radical nephrectomy as a significant risk factor for chronic kidney disease. [4] Due to the small size, early stage of tumors and advanced surgical techniques, surgeons were able to perform partial nephrectomies without sacrificing safety and oncology efficiency. [5] However, despite the use of partial nephrectomy some patients still progressed to chronic kidney disease.…”

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confidence: 99%