First, my deepest gratitude to God, the bible's author, who gives me hope and strength day by day. I know is difficult to express my huge gratitude to all friends and colleagues who directly and indirectly supported me during my doctorate period, but I am going to try using few words. I hope I will not forget anyone! I thank to Professor Eduardo Mario Mendiondo, my advisor, for giving me good opportunities to grow up personally and professionally, including my participation in both Graduate Programs in Brazil and the USA. Then, I thank to Professor Hoshin V. Gupta, my supervisor at The University of Arizona, who gave me the honor to work with and impressive lessons of being a top researcher, collaborator and a mentor. My very special thank to Danielle A. Bressiani, my lab colleague, that was (and is) an essential friend, with whom I shared life issues, technical discussions, and I could enjoy the advice from the "SWAT Queen"! I am also grateful for all other precious colleagues of my research group (NIBH) at University of São Paulo, who made my workdays much better, and sometimes funnier, such as: