Neovaginoplasty with tilapia fish skin: a series of eleven cases

Neovaginoplasty With Nile Tilapia Skin: Cytological and Microbiota Evaluation

“…20 Understanding the mechanisms of factors related to the host and microorganisms is essential to treat infections, reduce the risk of acquiring other infectious diseases, and prevent possible obstetric complications. 9 Oncotic cytology samples collected from neovaginas in this study revealed varied squamous cells in all patients, including superficial, intermediate, and parabasal squamous cells, similar to that of natural vaginas. Weyers et al (2010) 25 performed cytopathological examination of penile skin flap neovaginoplasty in 50 patients and found well-preserved squamous cells in 72%, lactobacilli in 4%, and inflammatory cells in 22% of the patients.…”

“…Further research is needed to establish a standard definition of dysbiosis in the neovagina and identify the patients who should be treated 20 . Understanding the mechanisms of factors related to the host and microorganisms is essential to treat infections, reduce the risk of acquiring other infectious diseases, and prevent possible obstetric complications 9 …”

“…Nile tilapia fish skin (NTFS) has noninfectious microbiota, 3 morphologic structure similar to human skin, 4 high in vivo bioresorption, 5 and showed good outcomes when used as a xenograft for burn treatment 6,7 . It provides an anatomical and functional vagina for women with agenesis, with high success and low morbidity rates 8,9 . This group had different cases of patients who needed neovaginoplasty surgery with positive results 10,11 …”

“…6,7 It provides an anatomical and functional vagina for women with agenesis, with high success and low morbidity rates. 8,9 This group had different cases of patients who needed neovaginoplasty surgery with positive results. 10,11 The predominance of lactobacilli in vaginal microbiota seems to be protective against infections, whereas dysbiosis with highly diverse microorganisms and without dominant lactobacilli present a higher risk of infections and obstetric complications.…”

Use of rainbow trout skin treated with glutaraldehyde as a mesh for abdominal hernioplasty in rats

“…Using fish and amphibian skin as the foundation for biological membranes is an expanding domain within regenerative medicine 10 , 11 , 12 , 13 . Fish skins facilitate cellular infiltration due to their absorbable nature and high collagen fiber content, expediting healing.…”