Neostigmine and edrophonium for reversal of pipecuronium neuromuscular blockade

Abdulatif, Mohamed; Naguib, Mohamed

doi:10.1007/bf03008137

Cited by 10 publications

(2 citation statements)

References 19 publications

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“…Neostigmine methylsulfate (NEO), chemically 3‐((Dimethylcarbamoyl) oxy)‐N, N, N‐trimethylanilinium methyl sulphate, was chosen as a model in our study because of its quaternary ammonium group and the degradable carbamate linkage as shown in Figure 1. NEO is a hydrolysable anti‐cholinesterase drug that reverses the effect of neuromuscular blockers which are widely used during anesthesia in hospitals [15]. NEO is frequently used to reverse the neuromuscular block because of its low cost [16].…”

Section: Introductionmentioning

confidence: 99%

Design of Copper Microfabricated Potentiometric Sensor for in‐line Monitoring of Neostigmine Degradation Kinetics

et al. 2021

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The quality of pharmaceutical products is critical for human health. Drug development requires tools to assess the presence of degradation products and contaminants during the manufacturing and storage processes. Accelerated stress degradation and kinetic studies play a vital role in predicting final product stability. This work describes the design of potentiometric sensor based on copper microfabricated electrodes for in‐line tracking the degradation kinetics of neostigmine. The proposed electrochemical technique provides a continuous profile for the hydrolysis of NEO under different temperatures and pH. The hydrolysis activation energy was found to be 18.88 kcal mol−1 which was aligned with the reported hydrolysable ester values. Consequently, the kinetic data analysis is crucial to predict the optimum analysis and storage conditions.

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Section: Introductionmentioning

confidence: 99%

Design of Copper Microfabricated Potentiometric Sensor for in‐line Monitoring of Neostigmine Degradation Kinetics

et al. 2021

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“…29 Moreover, it antagonizes the effect of neuromuscular blockers which is commonly used in emergency medicine and anesthesia in hospitals. 30 Postoperative neuromuscular residual block is considered as a serious threat associated with general anesthesia during surgeries. NEO is one of the most widely used anticholinesterase for neuromuscular blockade reversal due to its low cost.…”

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confidence: 99%

Neostigmine Potentiometric Sensors Based on Microfabricated Copper Electrodes Using Poly(3-octylthiophene) as an Ion-to-Electron Transducer Layer

El-Sayed

Mously

Mostafa

et al. 2020

J. Electrochem. Soc.

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The microfabricated potentiometric electrodes have been used in the field of medicine and biological sciences in the last few decades due to their various in-vivo sensing applications in addition to the cost effectiveness and easy processing. The proposed microfabricated electrodes use a low cost copper (Cu) substrate material on sensitized printed circuit board (PCB) which is easily patterned and compatible with the microfabrication processing. In this study, we further introduce the chemically prepared poly(3octylthiophene) (POT) as an ion-to-electron transducer layer between the microfabricated Cu electrode and the ionophore-doped ion-selective membrane. The incorporation of POT reduced the potential drift from ∼7 mV h −1 for bare Cu electrodes to ∼1 mV h −1 for POT modified Cu electrodes because of its hydrophobic nature. In addition, the dynamic response time was obviously decreased from (11 ± 7 s) to (3 ± 2 s) due to the fast transduction. Furthermore, ionophore screening has been performed using calix[6]arene and calix [4]arene to enhance the membrane selectivity towards neostigmine (NEO) as a model drug analyte. The proposed sensors showed higher sensitivity, lower LOD when compared to the ionophore-free membrane. The incorporation of calix [4]arene ionophore improved the selectivity towards NEO in the presence of its potential impurities.

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The current status of edrophonium: have we come “full circle”?

Kopman

1991

Can J Anaesth

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Neostigmine and edrophonium for reversal of pipecuronium neuromuscular blockade

Cited by 10 publications

References 19 publications

Design of Copper Microfabricated Potentiometric Sensor for in‐line Monitoring of Neostigmine Degradation Kinetics

Design of Copper Microfabricated Potentiometric Sensor for in‐line Monitoring of Neostigmine Degradation Kinetics

Neostigmine Potentiometric Sensors Based on Microfabricated Copper Electrodes Using Poly(3-octylthiophene) as an Ion-to-Electron Transducer Layer

The current status of edrophonium: have we come “full circle”?

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