Neosporosis in the aborted fetus and newborn calf

Ogino, Hiroaki; Watanabe, Eri; Watanabe, Soichi; Agawa, Hiroo; Narita, Minoru; Haritani, Makoto; Kawashima, Kenji

doi:10.1016/0021-9975(92)90039-w

Cited by 41 publications

(20 citation statements)

References 9 publications

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“…Two fetuses infected in utero and surgically removed (group 1) and 3 of 4 f t e uses surgically removed 26-31 days following maternal infection (groups 2-4) had systemic protozoa1 infections that were identical to those reported for spontaneous Neospora abortions. 4,17,21,22,27,28,29 Characteristic focal mononuclear inflammatory cell infiltrates were present in a variety of fetal tissues (Figs. 3-6).…”

Section: Discussionmentioning

confidence: 99%

“…2,[4][5][6][7]14,15,17,[20][21][22]24,[25][26][27][28]30 A causal role for Neospora production of bovine fetal neosporosis using a bovine tes be fu disease a lfilled by nd reisola experimental reprotion of the parasite.…”

mentioning

confidence: 99%

“…2,[4][5][6][7]12,14,15,[20][21][22][24][25][26][27][28][29][30] However, confirming the etiologic role of bovine Neospora as a cause of bovine abortion and congenital disease requires that Neospora isolate 9 obtained from a spontaneously aborted bovine fetus with confirmed Neospora infection.…”

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confidence: 99%

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Experimental Reproduction of Bovine Fetal Neospora Infection and Death with a Bovine Neospora Isolate

et al. 1994

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Abstract. Studies were conducted to determine the pathogenic potential of the recently isolated bovine Neospora protozoa (BPA-1) for the bovine fetus. Cows chosen for study had Neospora titers < 160 using an indirect immunofluorescent antibody (IFA) test. Four experimental groups were studied. In group 1, 2 fetuses were inoculated in utero at 118 days gestation with culture-derived Neospora tachyzoites. A pregnant control cow was housed in the same pen, observed daily and screened serologically for evidence of exposure to Neospora. In group 2, 2 cows were infected with Neospora tachyzoites at 138 or 161 days gestation, and 1 control cow was given uninfected cell culture suspension simultaneously at 154 days gestation. Groups 3 (85 days gestation) and 4 (120 days gestation) each consisted of 2 cows infected with Neospora tachyzoites and 1 control cow given uninfected material at the same stage of gestation. Dead fetuses were surgically removed from the infected cows in group 1 on postinfection day (PID) 17. The histopathology was compatible with protozoa1 fetal infection, and protozoa were identified by immunohistochemistry. Viable fetuses were removed surgically from cows in group 2 on PID 28-30. The histopathology was compatible with protozoa1 fetal infection, protozoa were identified by immunoperoxidase techniques, and Neospora tachyzoites were reisolated in vitro from tissues of the 2 infected fetuses. In groups 3 and 4, the control fetus and 1 infected fetus were removed surgically between PID 26 and PID 33. The remaining infected cows were observed until fetal death or abortion occurred. In group 3, the fetus that was surgically removed from 1 infected cow had no pathologic abnormalities, and parasites were not found (PID 26). The second fetus in group 3 died in utero, and expulsion of a mummified fetus was induced on PID 67. Brain histopathology was compatible with protozoa1 infection, and parasites were identified by immunoperoxidase techniques. The fetus that was surgically removed (PID 32) from 1 infected cow in group 4 had lesions compatible with protozoa1 infection, and Neospora tachyzoites were reisolated in vitro from fetal tissues. The second infected cow in group 4 produced a full-term live calf that had a precolostral Neospora titer of 20,480. Clinically, this calf had depressed conscious proprioception in all limbs. Very mild lesions were found in the central nervous system, but protozoa were not found in the tissues. The results demonstrate that the bovine Neospora protozoa can be transplacentally transmitted, resulting in fetal infection and death, and mimics the naturally occurring fetal disease.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Experimental Reproduction of Bovine Fetal Neospora Infection and Death with a Bovine Neospora Isolate

et al. 1994

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“…Canine neosporosis has been reported from many countries including Japan [2,7]. Bovine neosporosis has also been reported in Japan [5]. However, natural transmission of NC between or among these species have not been demonstrated yet.…”

Section: Sera Of Dogs From a Shetland Sheepdog Breeder (Group 3 And 4)mentioning

confidence: 99%

Serological Survey of Antibody to Neospora caninum in Japanese Dogs.

Sawada

Park

Kondo

et al. 1998

The Journal of Veterinary Medical Science

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ABSTRACT. Prevalence of antibody to Neospora caninum (NC) in Japanese dogs were examined. The antibody was positive in 15 of 48 dogs (31.3%) reared in the dairy farms that had case of the abortions due to NC infection or had the cattle seropositive to NC, whereas the prevalence was 7.1% (14 of 198 dogs) among the dogs kept in urban areas. In one dog breeder, all 17 Shetland sheepdogs older than 7 months were seropositive, and one pup was diagnosed as neosporosis 2 months before the first serological examination. The antibody titers of the dogs kept at this breeder were almost unchanged for 1.5 years. Serological evidence of the dogs in the dairy farms and urban areas indicates the transmission of NC between dogs and cattle. Also serological results of the dogs in one breeder may suggest the potential horizontal transmission among dogs. -KEY WORDS: canine, Neospora, seroprevalence.

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“…It has been reported in the United States [5], Australia [15], many European countries [2,14,18], and Asian countries such as Japan [12], Korea [7], Taiwan [13], Thailand [6] and Vietnam [4].…”

Section: Introductionmentioning

confidence: 99%

Finding ofNeospora caninumin the wild brown rat (Rattus norvegicus)

et al. 2004

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-Nine rats (16.4%) out of 55 (Rattus norvegicus) from cattle farms were seropositive to Neospora caninum. Two of the seropositive rats were also PCR positive but all were negative by immunohistochemistry and PAS staining. The brains of all the captured rats were homogenized and initially inoculated intraperitoneally into nude mice or into SPF ICR mice, which had been immunosuppressed with prednisolone. One mouse that was inoculated with brain material from a seropositive rat became infected with N. caninum, as demonstrated by the presence of a tissue cyst in the brain and confirmed by immunohistochemistry and PCR. This is the first finding of N. caninum in naturally infected farm rats. The findings show that natural N. caninum infection occurs in wild brown rats and thus rats may serve as a reservoir for the protozoan on the cattle farm. Neospora caninum / rat / cattle farm / natural infection

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Neosporosis in the aborted fetus and newborn calf

Cited by 41 publications

References 9 publications

Experimental Reproduction of Bovine Fetal Neospora Infection and Death with a Bovine Neospora Isolate

Experimental Reproduction of Bovine Fetal Neospora Infection and Death with a Bovine Neospora Isolate

Serological Survey of Antibody to Neospora caninum in Japanese Dogs.

Finding ofNeospora caninumin the wild brown rat (Rattus norvegicus)

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