Neoraudiol, a new isoflavonoid and other antimicrobial constituents from the tuberous root of Neorautanenia mitis (A. Rich) Verdcourt

Lasisi, A. A.; Adesomoju, Akinbo A.

doi:10.1016/j.jscs.2012.04.011

Cited by 10 publications

(8 citation statements)

References 8 publications

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“…They are also used as an anticonvulsant, anti-malarial, fish poison, insecticide, and for killing bilharziascarrying fresh water snails in many African countries [6][7][8][9][10]. The crude extracts and phytochemical constituents isolated from N. mitis have shown antidiarrheal [3,11], acaricidal, insecticidal [12], antinocicetive, antiinflammatory [9,13], larvicidal, mosquitocidal [14], cytotoxicity [11,15], and antimicrobial, activities [16]. H. abyssinica, is referred to as one of the strangest plants in the world, with its vegetative body consisting of only flowers, fruits and roots and has no leaves.…”

Section: Introductionmentioning

confidence: 99%

Isolation of bioactive compounds from medicinal plants used in traditional medicine: Rautandiol B, a potential lead compound against Plasmodium falciparum

Dawurung

Nguyen

Pengon

et al. 2021

BMC Complement Med Ther

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Background Neorautanenia mitis, Hydnora abyssinica, and Senna surattensis are medicinal plants with a variety of traditional uses. In this study, we sought to isolate the bioactive compounds responsible for some of these activities, and to uncover their other potential medicinal properties. Methods The DCM and ethanol extracts of the roots of N. mitis and H. abyssinica, and the leaves of S. surattensis were prepared and their phytochemical components were isolated and purified using chromatographic methods. These extracts and their pure phytochemical components were evaluated in in-vitro models for their inhibitory activities against Plasmodium falciparum, Trypanosoma brucei rhodesiense, Mycobacterium tuberculosis, α-amylase (AA), and α-glucosidase (AG). Results Rautandiol B had significant inhibitory activities against two strains of Plasmodium falciparum showing a high safety ratio (SR) and IC50 values of 0.40 ± 0.07 μM (SR - 108) and 0.74 ± 0.29 μM (SR - 133) against TM4/8.2 and K1CB1, respectively. While (−)-2-isopentenyl-3-hydroxy-8-9-methylenedioxypterocarpan showed the highest inhibitory activity against T. brucei rhodesiense with an IC50 value of 4.87 ± 0.49 μM (SR > 5.83). All crude extracts showed inhibitory activities against AA and AG, with three of the most active phytochemical components; rautandiol A, catechin, and dolineon, having only modest activities against AG with IC50 values of 0.28 mM, 0.36 mM and 0.66 mM, respectively. Conclusion These studies have led to the identification of lead compounds with potential for future drug development, including Rautandiol B, as a potential lead compound against Plasmodium falciparum. The relatively higher inhibitory activities of the crude extracts against AG and AA over their isolated components could be due to the synergistic effects between their phytochemical components. These crude extracts could potentially serve as alternative inhibitors of AG and AA and as therapeutics for diabetes.

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Section: Introductionmentioning

confidence: 99%

Isolation of bioactive compounds from medicinal plants used in traditional medicine: Rautandiol B, a potential lead compound against Plasmodium falciparum

Dawurung

Nguyen

Pengon

et al. 2021

BMC Complement Med Ther

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“…Other research groups extracted the plant materials with acetone [42][43][44], CHCl 3 [45,46], CH 2 Cl 2 [47][48][49][50] or diethyl ether [51] at room temperature. Successive extraction starting with petroleum ether or hexane, CHCl 3 , EtOAc and MeOH using soxhelt apparatus [52][53][54][55][56] was also reported. The isoflavone contents of soybeans were extract using supercritical fluid extraction [57].…”

Section: Extraction and Purificationmentioning

confidence: 99%

“…The two isoflavans 3S (+) 2′-O-Methylphaseollidinisoflavan (15) and 3R(-)Erythbidin A (16) isolated from E. caffra as well as the two isoflavanones 5,7-Dihydroxy-2′-methoxy-3′,4′-methylenedioxyisoflavanone (31) and 4′,5-Dihydroxy-2′,3′-dimethoxy-7-(5-hydroxyoxychromen-7yl)-isoflavanone (155) isolated from Uraria picta were active against S. aureus [45,55]. The isoflavone Neoraudiol (111) displayed antimicrobial activity on Bacillus subtilis, Salmonella typhii and Candida albicans [52]. Lachnoisoflavone A (91) from Crotalaria lachnophora showed moderate inhibitory activities against Escherichia coli and Klebsiella pneumonia [76].…”

Section: Flavonoids -From Biosynthesis To Human Healthmentioning

confidence: 99%

Isoflavonoids

Foudah¹,

Abdel-Kader²

2017

Flavonoids - From Biosynthesis to Human Health

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Isoflavonoids are interesting class of natural products due to their positive effects on human health. Isoflavonoids include isoflavones, isoflavanones, isoflavans, rotenoids and pterocarpans. Although they are reported from many plant families, most isoflavonoids are produced by the subfamily Papilionaceae of the Fabaceae. Various chromatographic methods have been applied for the purification of isoflavonoids. Simple Ultra Violet (UV) absorption spectra as well as both One and two dimensional NMR (1D-and 2D-NMR) are critical for the identification of isoflavonoids. Each class of isoflavonoids has its unique feature in both 1 H-and 13 C-NMR that enable their proper characterization. High Resolution Mass Spectrometry (HRMS) is a substantial tool in such challenge. In vitro experiments indicated that isoflavonoids possess antioxidant, antimutagenic, antiproliferative as well as cancer preventive effects. Epidemiological studies provide support for some of these effects on human. Members of this class also are reported to have antimicrobial activity. In this chapter, isoflavones, isoflavanones, isoflavans, homoisoflavonoids and isoflavenes will be discussed in relation to their occurrence, methods of purification, spectral characters helpful in structure elucidation as well as their biological importance.

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“…In addition, antispasmodic, analgesic, antiinflammatory, antitumor (Sakurai et al 2006), acaricidal (Puyvelde et al 1987), molluscicidal (Puyvelde et al 1987;Puyvelde et al 1990), and larvicidal and mosquitocidal (Joseph et al 2004) activities have been observed. Cytotoxic activities of the EtOAc extract of N. mitis were also described for human MCF-7 breast and A-549 lung cancer cells (Lasisi and Adesomoju 2015). The possibility of using its starch in tablet formulation was also explored recently (Olayemi et al 2016).…”

Section: Introductionmentioning

confidence: 99%

HPLC-UV Method for Standardization of Neorautanenia mitis, an African Plant Used in an Anti-Scabies Ointment

Kagisha

Frédérich

Ledoux

et al. 2020

Rev. Bras. Farmacogn.

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An HPLC-UV method for standardization of the methanol-soluble extracts from tubers of Neorautanenia mitis (A.Rich.) Verdc., Fabaceae, harvested during different periods and from different sites, is described. The chemical fingerprint was established with six identified markers using LC-ESI (+)-MS/MS, including rotenone; the total error was used as validation criterion, the accuracy and risk profiles demonstrated the reliability of the method. The study verified that the major degradation product of rotenone in methanol is dehydrorotenone. The detection range of rotenone was between 40 and 400 μg/ml. The collected samples contained 868-5732 μg/g of rotenone. The concentrations of rotenone in the wild samples from the Ngoma site (5167 ± 565 μg/g) were higher than those registered in the samples from the other sites. No significant differences were observed among the remaining sampling sites, and most of the rotenone was located in the inner part of the tubers (2165 ± 1051 μg/g) when compared with that in their peels (961 ± 320 μg/g).

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Neoraudiol, a new isoflavonoid and other antimicrobial constituents from the tuberous root of Neorautanenia mitis (A. Rich) Verdcourt

Cited by 10 publications

References 8 publications

Isolation of bioactive compounds from medicinal plants used in traditional medicine: Rautandiol B, a potential lead compound against Plasmodium falciparum

Isolation of bioactive compounds from medicinal plants used in traditional medicine: Rautandiol B, a potential lead compound against Plasmodium falciparum

Isoflavonoids

HPLC-UV Method for Standardization of Neorautanenia mitis, an African Plant Used in an Anti-Scabies Ointment

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