Neopterin und Neopterin-3′-phosphat als Vorläufer der Folsäure bei Mycobacterium smegmatis

Abstract

Extracts of Mycobacterium smegmatis synthesise dihydro-pteroate and dihydro-folate from dihydro-pteridine-6-carbinol as well as from dihydro-neopterin and dihydro-neopterin-3′-phosphate. The 7-isomers of the pteridine precursors are neither substrates nor inhibitors of folate biosynthesis. Side-chain 14C-labelled dihydro-neopterin yields similarly labelled dihydro-folate. From the isotopic data it is concluded that a two-carbon fragment is split off the chain and that C-1′ of dihydroneopterin becomes the bridging methylene group between the pteridine and the p-aminobenzoyl moiety of the compound produced.

Intermediary metabolism of mycobacteria.

“…The synthesis of dihydrofolate and dihydropteroate from dihydroneopterin by extracts of M. smegmatis has been reported by Jaenicke et al (168). The isomers of the pteridine precursors are neither substrates nor inhibitors of folate biosynthesis.…”