Neopterin formation through radical scavenging of superoxide by the macrophage synthesised antioxidant 7,8-dihydroneopterin

Baxter-Parker, Gregory; Prebble, Hannah M.; Cross, Sean; Steyn, Nina; Shchepetkina, Anastasia; Hock, Barry D.; Cousins, Andrew; Gieseg, Steven P.

doi:10.1016/j.freeradbiomed.2020.03.002

Cited by 13 publications

(10 citation statements)

References 44 publications

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“…H 2 Nep is also an important ROS scavenger. While peroxyl and hydroxyl scavenging generates dihydroxanthopterin (H 2 Xap), hypochlorite efficiently oxidizes H 2 Nep into Nep [ 119 ]. Superoxide reacts with H 2 Nep, which results in Nep formation.…”

Section: Redox Chemistry Of Pterins and Their Free Radical Speciesmentioning

confidence: 99%

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Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Buglak

Kapitonova

Vechtomova

et al. 2022

IJMS

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Pterins are an inseparable part of living organisms. Pterins participate in metabolic reactions mostly as tetrahydropterins. Dihydropterins are usually intermediates of these reactions, whereas oxidized pterins can be biomarkers of diseases. In this review, we analyze the available data on the quantum chemistry of unconjugated pterins as well as their photonics. This gives a comprehensive overview about the electronic structure of pterins and offers some benefits for biomedicine applications: (1) one can affect the enzymatic reactions of aromatic amino acid hydroxylases, NO synthases, and alkylglycerol monooxygenase through UV irradiation of H4pterins since UV provokes electron donor reactions of H4pterins; (2) the emission properties of H2pterins and oxidized pterins can be used in fluorescence diagnostics; (3) two-photon absorption (TPA) should be used in such pterin-related infrared therapy because single-photon absorption in the UV range is inefficient and scatters in vivo; (4) one can affect pathogen organisms through TPA excitation of H4pterin cofactors, such as the molybdenum cofactor, leading to its detachment from proteins and subsequent oxidation; (5) metal nanostructures can be used for the UV-vis, fluorescence, and Raman spectroscopy detection of pterin biomarkers. Therefore, we investigated both the biochemistry and physical chemistry of pterins and suggested some potential prospects for pterin-related biomedicine.

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Section: Redox Chemistry Of Pterins and Their Free Radical Speciesmentioning

confidence: 99%

“…Superoxide reacts with H 2 Nep, which results in Nep formation. H 2 Nep reacted with O 2 •− /OH • mixtures generated by X-ray radiolysis to Nep [ 119 ]. Production of Nep by O 2 •− obtained from the xanthine/xanthine oxidase system was inhibited by superoxide dismutase.…”

Section: Redox Chemistry Of Pterins and Their Free Radical Speciesmentioning

confidence: 99%

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Buglak

Kapitonova

Vechtomova

et al. 2022

IJMS

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“…It was positively correlated with these metabolites with anti-aging effects including 7,8-dihydroneopterin, erythro-6,8-pentacosanediol, propionylcarnitine and N-oleoyl glycine, which had been reported in previous studies. [35][36][37][38] So far, no linkage has been found between Romboutsia and aging in humans or animals. Carbohydrates can be digested by Romboutsia ilealis, a common and abundant bacterium in the colon.…”

Section: Food and Function Papermentioning

confidence: 99%

Anti-aging potency correlates with metabolites from in vitro fermentation of edible fungal polysaccharides using human fecal intestinal microflora

et al. 2022

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“…Neutrophils produce both superoxide through the action of NADPH-oxidase, and hypochlorite by the action of myeloperoxidase. Both oxidants rapidly react with 7,8-dihydroneopterin to generate neopterin so protecting the cell from oxidative damage [11][12][13]. The TNP/NP ratio is doubled in plasma compared to urine, indicating an increased presence of 7,8-dihydroneopterin in a patients plasma.…”

Section: Time (Hours)mentioning

confidence: 99%

“…Clinical data indicates that plasma neopterin may be useful in early detection of sepsis development after trauma or surgery, as well as sepsis progression [9,10]. Neopterin is an oxidation product of its parent compound, 7,8-dihydroneopterin [11][12][13], a monocyte and macrophage cell synthesised antioxidant [14] produced upon activation of the immune system [15]. Therefore, neopterin can be used as a biomarker for immune derived oxidative stress and 7,8-dihydroneopterin as a biomarker for monocyte and macrophage cell activation [16,17].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

et al. 2020

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Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored. We examine the levels of oxidative stress, inflammation and kidney function in intensive patients and compare them to equivalent patients without sepsis.Methods: 34 Intensive care patients were selected for the study, 14 without sepsis and 20 with. Both groups had equivalent levels of trauma, assessed by SAPS II, SOFA, and APACHE II and III scores. Plasma and urinary neopterin and total neopterin (neopterin + 7,8-dihydroneopterin) values were measured.Results: Neopterin and total neopterin were significantly elevated in urine and plasma for multiple days in sepsis versus non-sepsis patients. Plasma neopterin and total neopterin have decreasing relationships with increased eGFR (p<0.008 and p<0.001, respectively). Plasma/urinary neopterin and total neopterin ratios demonstrate that total neopterin flux is more influenced by eGFR than neopterin, with significantce of p<0.02 and p<0.0002 respectively.Conclusion: Sepsis patients present with greater levels of oxidative stress and immune system activation than non-sepsis patients of equal levels of trauma, as measured by neopterin and total neopterin. eGFR may need to be taken into account when accessing the level of inflammation from urinary neopterin measurements.

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Neopterin formation through radical scavenging of superoxide by the macrophage synthesised antioxidant 7,8-dihydroneopterin

Cited by 13 publications

References 44 publications

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Insights into Molecular Structure of Pterins Suitable for Biomedical Applications

Anti-aging potency correlates with metabolites from in vitro fermentation of edible fungal polysaccharides using human fecal intestinal microflora

Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis

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