Neopterin and other indicators of HIV progression in Zambian adults

Hosp, M; Quigley, Maria A.; Mwinga, Am; Godfrey‐Faussett, Peter; Porter, John; McAdam, K.P.W.J.; Fuchs, O

doi:10.1515/pteridines.2000.11.2.37

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…Another similar study by Bipath et al (2015) which states that neopterin can be a marker of disease progression and outcome of HIV / AIDS patients. In addition, the results are similar to previous studies by Hosp et al in Zambian (2000), but in that study, the periods were longer, patients were followed for a minimum of 3 months to 12 months, and measurements were taken of the initial neopterin levels and after 12 months (p <0.05) (4,20,21).…”

Section: Discussionsupporting

confidence: 89%

Association Between Neopterin Levels and Outcome in 30 Day HIV/AIDS Naive Patients

Juanita

Hadi

Arfijanto

2019

BHSJ

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Introduction: HIV/AIDS is still a major problem throughout the world even in Indonesia. Some markers can provide information regarding the description of immune activity in HIV/AIDS. Neopterin produced by macrophages as a catabolic result of Guanosine Triphosphate (GTP) is one of them. Neopterin has been widely studied as a prognostic indicator of the course in HIV/AIDS. Until now there have been no studies examine the association between neopterin levels and outcomes in 30 days of HIV/AIDS patients.Methods: A prospective longitudinal analytic study involved 56 samples of HIV/AIDS naive patients from January to April 2019. Serum neopterin levels were measured by the Enzyme Linked Immunosorbent Assay (ELISA) method. Outcome is a living condition or death within the first 30 days of the patient being treated. Discriminant function analysis was used to determine the association between variable and controlling confounding factors using the "R" program. Outputs of p value was significant if <0.05.Results: The average age of the study subjects was 39.7 ± 11 years old with predominantly male gender (71.4%). The median serum neopterin level of the study subjects was 168.13 nmol/L with the lowest levels of 11.78 nmol/L and the highest level of 196.95 nmol/L. Outcomes were grouped live and died, each group at 50%. There was a significant positive association between serum neopterin levels and outcomes in 30 days (p=0.02)Conclusion: Role of neopterin levels still need to be proven as a prognostic factor by evaluating other factors that influence the outcome of HIV/AIDS patients.

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Section: Discussionsupporting

confidence: 89%

Association Between Neopterin Levels and Outcome in 30 Day HIV/AIDS Naive Patients

Juanita

Hadi

Arfijanto

2019

BHSJ

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“…The current study revealed that the serum level of neopterin could be considered as a valuable biochemical marker for cellular immune response among the exposed smelter workers. Similarly, previous studies declared that neopterin levels were well correlated with counts of CD4+ and CD8+ T-cells and cytokines levels in the experimental populations (Hosp et al, 2000 andFrench et al, 2009).…”

Section: Both Cytokines;supporting

confidence: 70%

Alteration of the Immune Functions Among Workers of Secondary Aluminum Smelting

2023

Egypt. J. Occup. Med.

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Introduction:The immune functions could be altered due to the exposure to heavy metals. Although the impact of heavy metals on the immune system among human populations is poorly understood, however, several recent studies illustrated the immunological changes due to human exposure to Aluminum (Al) and Lead (Pb). Aim of Work: to study the alteration in some cellular and humoral immune components among some Egyptian Al smelter workers. Materials and Methods: The studied group was composed of 55 exposed male workers in Al smelter and a matched control group of 55 administrative subjects. Full medical and occupational histories, clinical examination, and laboratory investigations including (levels of serum Al, blood Pb, serum neopterin, TNF-α, IL-2, C3, C4, IgM, IgG, total IgE, and count of CD4+ and CD8+ T-lymphocytes) were performed for the Al smelter's workers and their matched controls. Results: Clinically, the exposed smelter workers showed a significant prevalence of some manifestations as allergy, inflammation, and infections, when compared with the control group. Besides, significantly elevated levels of Al, Pb, neopterin, total IgE, and CD8+ T-lymphocytes count in addition to significantly diminished levels of TNF-α, IL-2, C3, C4, IgM, IgG, and CD4+ T-lymphocytes count were detected among the exposed group compared to their controls. Moreover, all the investigated immune parameters were significantly correlated to the duration /years of employment and the levels of both studied heavy metals in the exposed smelter's workers. Moreover, the neopterin levels were significantly correlated with the parameters of cellular immunity (CD4+, CD8+ cells, and cytokines). Conclusion: There was a significant alteration in the cellular and humoral immune functions among the smelter workers occupationally exposed to Al and Pb. Additionally; neopterin could be considered a significant biomarker for the response of cell-mediated immunity.

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“…This is in accordance with a recent retrospective marker validation study (ACTG 116B/117) showing that neopterin was the strongest predictor of disease progression in advanced HIV infection. 32 We have previously shown that neopterin and hemoglobin are highly correlated, 33 and anemia in HIV infection is partly attributable to chronic immune stimulation. 34 In European patients (Eurosida cohort), hemoglobin was an independent risk factor of death.…”

Section: Discussionmentioning

confidence: 99%

HIV Progression and Predictors of Mortality in a Community-Based Cohort of Zambian Adults

Kitchen

Quigley

Mwinga

et al. 2007

Journal of the International Association of Physicians in AIDS

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This article describes immunological HIV progression, mortality, and its predictors in 974 Zambian adults. During 3138 person-years of follow-up, 281 deaths occurred, and the overall mortality rate was 9.0 per 100 person-years. Thirty-six percent of patients were dead within 5 years of enrollment. The median survival in patients with baseline CD4 count ≥500 cells/mm³ was 5.62 years, with CD4 count between 200 and 499 cells/mm³ 5.46 years, and with CD4 count <200 cells/mm³ 3.89 years. The mortality rate increased significantly with older age (6.9 in patients <25 years, 9.3 in individuals aged 25-39 years, 10.2 in patients ≥40 years) and was higher in women (rate ratio 1.29). The median annual change of progression markers was -29.6 cells/mm³ for CD4 count, -3.0% for CD4 count percentage, 1.2 nmol/L for neopterin, -1.9 g/L for hemoglobin, and -70 cells/mm³ for total lymphocyte count. Hemoglobin and neopterin were as accurate as CD4 count to predict mortality.

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Neopterin and other indicators of HIV progression in Zambian adults

Cited by 3 publications

References 13 publications

Association Between Neopterin Levels and Outcome in 30 Day HIV/AIDS Naive Patients

Association Between Neopterin Levels and Outcome in 30 Day HIV/AIDS Naive Patients

Alteration of the Immune Functions Among Workers of Secondary Aluminum Smelting

HIV Progression and Predictors of Mortality in a Community-Based Cohort of Zambian Adults

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