Neopterin: A potential marker in chronic peripheral arterial disease

Signorelli, Salvatore Santo; Anzaldi, Massimiliano; Fiore, Valerio; Candido, Saverio; Marco, Roberto Di; Mangano, Katia; Quattrocchi, Cinzia; Neri, Sergio

doi:10.3892/mmr.2013.1407

Cited by 14 publications

(17 citation statements)

References 39 publications

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“…The results also revealed an indirect correlation between neopterin levels, CD and ABI, where an increase in neopterin values was associated with a significant decrease of ABI. Similar results have been reported by Signorelli et al and Barani J. et al [ 28 , 61 , 62 , 63 , 64 ].…”

Section: Discussionsupporting

confidence: 91%

“…Neopterin, a member of the pteridine family, is an indicator of macrophage activation [26,27]. Several investigators have reported a relationship between neopterin and atherosclerosis plaque progression or instability [28]. Beta 2-macroglobulin (B2-MG), a component of the major histocompatibility complex class I molecule, is an acute-phase reactant protein, whose levels were described as elevated in patients with carotid artery intima-media thickening and arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

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Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

et al. 2020

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Peripheral arterial disease (PAD) is a common manifestation of generalized atherosclerosis, which affects more than 200 million patients worldwide. Currently, there is no ideal biomarker for PAD risk stratification and diagnosis. The goal of this research was to investigate the levels of inflammation biomarkers and cystatin C and to explore their utility for the diagnosis of PAD. The study included 296 participants, distributed in two groups: 216 patients diagnosed with PAD and 80 patients without PAD as controls. All studied biomarker levels (C-reactive protein, CRP; fibrinogen; erythrocyte sedimentation rate, ESR; neopterin; beta 2-microglobulin, B2-MG; and cystatin C) were significantly higher in the PAD group and indirectly correlated with the ankle–brachial index (ABI). The final logistic regression model included an association of neopterin, fibrinogen, and cystatin C as the most efficient markers for the prediction of PAD diagnosis. When comparing the area under the curve (AUC) for all biomarkers, the value for neopterin was significantly higher than those of all the other analyzed biomarkers. In agreement with previous studies, this research shows that markers such as fibrinogen, CRP, ESR, B2-MG, and cystatin C have significant value for the diagnosis of PAD, and also clearly underlines the accuracy of neopterin as a leading biomarker in PAD prediction.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

et al. 2020

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“…While neopterin has been measured repeatedly as an assessment of macrophage activation and infiltration for several decades [ 5 , 48 , 61 , 62 , 63 ], complete estimation of immune activation through total neopterin analysis has limited transparency for clinical outcomes. In 1989, Fuchs et al [ 16 ] measured neopterin plus 7,8-dihydroneopterin in HIV patients, suggesting that both provide equal potential for clinical diagnosis.…”

Section: Clinical Effectiveness Of Neopterin and Total Neopterinmentioning

confidence: 99%

“…Contrasting results suggest that its accumulation may be intensity-dependent [ 76 , 77 ], as the impacts and total running distance during a game of rugby strongly correlate with the observed increase in neopterin and total neopterin concentration [ 73 ]. Recently, neopterin has also been used to assess the positional demands of professional rugby players [ 78 ], and used to evaluate the effectiveness of post-game rugby union recovery interventions [ 79 ], the efficacy of cold water immersion [ 1 , 2 , 3 ], stress perturbations associated with ischemic preconditioning [ 4 ], and the monitoring of season-long stress fluctuations in professional rugby players [ 5 ].…”

Section: Clinical Effectiveness Of Neopterin and Total Neopterinmentioning

confidence: 99%

“…The level of clinical inflammation occurring as a result of physical trauma, cardiovascular disease, cancer, bacterial, parasitic infections, and viral infections is often assessed by measuring the concentration of plasma and urinary neopterin [ 1 , 2 , 3 , 4 , 5 ]. Neopterin analysis is used as the primary screen of blood donations in Australia as an indicator for safe blood transfusion [ 6 ].…”

Section: Introduction To Neopterin and 78-dihydroneopterinmentioning

confidence: 99%

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Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?

Gieseg

Lindsay

2018

Antioxidants

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Neopterin has been extensively used as a clinical marker of immune activation during inflammation in a wide range of conditions and stresses. However, the analysis of neopterin alone neglects the cellular reactions that generate it in response to interferon-γ. Neopterin is the oxidation product of 7,8-dihydroneopterin, which is a potent antioxidant generated by interferon-γ-activated macrophages. 7,8-Dihydroneopterin can protect macrophage cells from a range of oxidants through a scavenging reaction that generates either neopterin or dihydroxanthopterin, depending on the oxidant. Therefore, plasma and urinary neopterin levels are dependent on both macrophage activation to generate 7,8-dihydroneopterin and subsequent oxidation to neopterin. This relationship is clearly shown in studies of exercise and impact-induced injury during intense contact sport. Here, we argue that neopterin and total neopterin, which is the combined value of 7,8-dihydroneopterin and neopterin, could provide a more comprehensive analysis of clinical inflammation than neopterin alone.

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Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial

et al. 2021

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Purpose Primarily, to investigate the effect of high intake of cod (lean fish) or salmon (fatty fish) on serum concentration of total neopterin, a marker of cellular immune activation that is associated with cardiovascular disease. Second, to investigate effects of high cod/salmon intake on antioxidant vitamins and elements essential for activity of antioxidant enzymes. Methods In this randomised clinical trial, 63 participants with overweight/obesity consumed 750 g/week of either Atlantic cod (N = 22) or Atlantic salmon (N = 22) or were instructed to continue their normal eating habits but avoid fish intake (Control group, N = 19) for 8 weeks. Food intake was recorded, and fasting serum were collected at baseline and endpoint. Results Serum total neopterin concentration was reduced in the Cod group (median change − 2.65 (25th, 75th percentiles − 3.68, − 0.45) nmol/l, P = 0.018) but not in the Salmon group (median change 0.00 (25th, 75th percentiles − 4.15, 3.05) nmol/l, P = 0.59) when compared with the Control group after 8 weeks. The estimated daily intake of selenium, iron, magnesium and zinc were similar between all groups. Increased serum concentration of selenium was observed only after cod intake when compared to the Control group (P = 0.017). Changes in serum concentrations of copper, iron, magnesium, all-trans retinol, α-tocopherol and γ-tocopherol were similar between the groups. Conclusion A high intake of cod, but not of salmon, lowered serum total neopterin concentration when compared to the Control group. Clinical trial registration This trial was registered at clinicaltrials.gov as NCT02350595

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Neopterin: A potential marker in chronic peripheral arterial disease

Cited by 14 publications

References 39 publications

Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?

Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial

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