Neoplastic transformation of v. Meyenburg complexes of the liver

Homer, L. W.; White, Harold J.; Read, R. C.

doi:10.1002/path.1700960231

Cited by 66 publications

(22 citation statements)

References 2 publications

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“…von Meyenburg's complex (biliary microhamartoma) consists of variably dilated small ducts, some of which contain inspissated bile. A few cases reported thus far suggest that this tumor can undergo malignant transformation 51,. On occasion, it is important to distinguish small‐sized, well differentiated, peripheral ICC from von Meyenburg's complex or bile duct adenoma.…”

Section: Hepatobiliary Diseases Preceding Icc Including Precancerousmentioning

confidence: 99%

Precancerous lesions of intrahepatic cholangiocarcinoma

Shimonishi

Sasaki

Nakanuma

2000

Journal of Hepato-Biliary-Pancreatic Surgery

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Intrahepatic cholangiocarcinoma (ICC), also known as cholangiocellular carcinoma or peripheral bile duct carcinoma, is an intrahepatic malignant tumor that consists of cells resembling the biliary epithelium. The proportion of ICC among primary hepatic malignancies is approximately 10% worldwide. Although the etiology and pathogenesis remain unclear in a great majority of cases, preceding pathologic conditions or etiologies in the development of ICC are known or suspected in a proportion of these patients. Some forms of ICC, such as those associated with hepatolithiasis or liver fluke infestation, are endemic in parts of the world, particularly in East Asia. ICC is reportedly a late complication of primary sclerosing cholangitis. Most of these preceding pathologic conditions are forms of chronic cholangitis, and longstanding inflammation, chronic injury, and regenerative hyperplasia of the biliary epithelium may be causally related to malignant transformation. Biliary epithelial dysplasia is encountered in the intrahepatic bile ducts both near and remote from ICC foci in the liver and near and remote from the chronically inflamed biliary tree. This lesion could be a precancerous lesion, and it shows telomerase activity and increased proliferative activities. Furthermore, congenital and developmental disorders of the biliary system, such as Caroli's disease, congenital hepatic fibrosis, and pancreatico-biliary malformation are occasionally associated with ICC. Benign biliary tumors, such as biliary papillomatosis, may eventually undergo malignant transformation. These lesions could be regarded as precancerous or borderline lesions. Some ICCs may also develop in nonbiliary viral cirrhosis. In the majority of cases of ICC, however, the etiology, pathogenesis, and developmental processes and precancerous lesions of the ICC remain unclear.

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Section: Hepatobiliary Diseases Preceding Icc Including Precancerousmentioning

confidence: 99%

Precancerous lesions of intrahepatic cholangiocarcinoma

Shimonishi

Sasaki

Nakanuma

2000

Journal of Hepato-Biliary-Pancreatic Surgery

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“…A rare compli- cation of these diseases may be cholangiocarcinoma [24][25][26][27]. Only a few case reports have described cholangiocarcinoma associated with MBH [1,24,25,[28][29][30]. Jain et al reported three cases of cholangiocarcinoma, and they could demonstrate a gradual transition from MBH to hyperplastic or adenomatous lesions, and then cholangiocarcinoma [28].…”

Section: Discussionmentioning

confidence: 99%

Multiple biliary hamartomas: magnetic resonance features with histopathologic correlation

et al. 2007

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The purpose of this study was to report the magnetic resonance imaging (MRI) features of multiple biliary hamartoma (MBH) and to correlate them with histopathology. MRI features of 11 patients with MBH proven by histology were retrospectively reviewed and correlated to histopathology. MBH presented as multiple, tiny, and uniformly distributed lesions in all cases. All were hypointense on T1-weighted images and hyperintense on T2-weighted images relative to the liver parenchyma. Mural nodules were identified in 10 of 11 (91%) cases. They were isosignal on T1-weighted images, intermediate signal on T2-weighted images. Gadolinium-enhanced images showed mural nodule enhancement in 9 of 10 patients (90%) or a peripheral rim-like enhancement of the whole lesion in one case (9%). MBH were present in all liver specimens. In the six patients examined at MR cholangiography, the lesions lacked communication with the biliary tree. At histopathology, the mural nodule corresponded to an endocystic polypoid projection made of conjunctive septa. Three (27%) patients had associated focal nodular hyperplasia, and 1 (9%) had concomitant cholangiocarcinoma. MRI features allowed diagnosis of MBH with accuracy. Their recognition, especially the mural nodule, may help avoid misdiagnosis.

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“…8 A few cases in which biliary hamartomas, biliary dysplasia, or cholangiocarcinoma coexisted have been reported. [9][10][11][12] Abdominal ultrasonography of biliary hamartomas may show hypoechoic, hyperechoic, or mixed-echoic lesions, due to different compositions of the lesions. 13,14 CT shows multiple cystoid lesions without enhancement after the administration of intravenous contrast media.…”

Section: Discussionmentioning

confidence: 99%

Biliary hamartomas with delayed 99mTc-diisopropyl iminodiacetic acid clearance

et al. 2005

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We report a 61-year-old asymptomatic man who had a hepatic lesion whose nature was undetermined, based on biochemistry, serology, ultrasonography, computed tomography, and magnetic resonance imaging studies. Biliary hamartomas were diagnosed by echo-guided needle biopsy. Functional studies of bile excretion, using 99mTc-diisopropyl iminodiacetic acid (99mTc-DISIDA) scintigraphy liver single-photon emission computed tomography (SPECT) showed the delayed transit of tracers from hepatocytes to the biliary hamartomas and the delayed emptying of tracers to the neighboring bile ducts. Therefore, biliary hamartomas should be included in the differential diagnosis of single or multiple hepatic lesions whose nature is undetermined, and a liver biopsy would be warranted for further treatment plans. We believe this is the first functional study of bile excretion in biliary hamartomas using radionucleotide studies; such studies may have prognostic implications.

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Neoplastic transformation of v. Meyenburg complexes of the liver

Cited by 66 publications

References 2 publications

Precancerous lesions of intrahepatic cholangiocarcinoma

Precancerous lesions of intrahepatic cholangiocarcinoma

Multiple biliary hamartomas: magnetic resonance features with histopathologic correlation

Biliary hamartomas with delayed 99mTc-diisopropyl iminodiacetic acid clearance

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