Neoplastic precursors (dysplasia, intraepithelial neoplasia) of the gallbladder and biliary tract: terminology, classification, pathologic diagnosis, and clinical significance

Xue, Yue; Quigley, Brian; Akkaş, Gizem; Adsay, Volkan

doi:10.1016/j.mpdhp.2015.06.023

Cited by 3 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The former are commoner and proceed to carcinogenesis through a metaplasia-dysplasia cancer pathway [ 1 , 2 ]. The latter have been described under a variety of names including papillary adenomas, tubulopapillary adenomas, intestinal adenomas, and others [ 3 ]. The World Health Organization 2010 classification distinguishes two categories, the “adenomas” and the “intracystic papillary neoplasms” [ 4 ] but without providing specific diagnostic criteria and thus allowing significant overlapping.…”

Section: Introductionmentioning

confidence: 99%

“…This definition unifies a wide spectrum of previously described neoplastic and preneoplastic lesions of the gallbladder including papillary adenomas, tubulopapillary adenomas, intestinal adenomas, biliary adenomas, transitional adenomas, papillary neoplasms, papillary carcinomas, and intracystic papillary neoplasm. Their definition as a single category derives from their common clinicopathological, immunophenotypic and molecular characteristics, their better prognosis, and homology to other papillary neoplasms of the pancreatobiliary track, including pancreatic IPMNs and biliary IPBNs [ 3 ]. The criterion of 1.0 cm is arbitrary yet relevant since tumors <1 cm are usually undetectable preoperatively and almost universally benign [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Macroscopically, they are polypoid lesion presenting large villous/papillary growths with smooth surface projections. They can be sessile or pedunculated [ 3 ]. According to Adsay et al [ 5 ], ICPNs can be of papillary (43 %), tubular (23 %), or mixed (31 %) configuration and of biliary (50 %), gastric (36 %), intestinal (11 %), or oncocytic (9 %) cellular lineage.…”

Section: Introductionmentioning

confidence: 99%

“…ICPN component at invasive cancer usually is of papillary configuration and has a more extensive component of high-grade dysplasia, indicating a stepwise progression to carcinoma [ 5 ]. The difference in prognosis can be attributed to their exophytic nature causing earlier symptoms and earlier diagnosis or an inherent more indolent biology [ 3 , 8 , 9 , 13 ]. Notably, similar conclusions have been reached for IPBNs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst: a link between choledochal cyst and gallbladder cancer?

et al. 2016

View full text Add to dashboard Cite

BackgroundIntracholecystic papillary-tubular neoplasms are rare precursor lesions of gallbladder cancer. They were proposed as a separate pathologic entity in 2012 by Adsay et al. for the unification of a variety of mass-forming precursor lesions including papillary adenomas, tubulopapillary adenomas, intestinal adenomas, and others. They are considered homologous to intrapapillary mucinous neoplasms of the pancreas and intrabiliary papillary neoplasms of the common bile duct. In contrast with the commoner flat-type precursor gallbladder cancer lesions, they follow a more indolent clinical course and probably different genetic pathways to carcinogenesis. They are largely uninvestigated with only a handful of studies providing biological and clinical information. Choledochal cysts are dilation of the common bile duct. Diagnosis is usually established during childhood, and only a minority of patients are diagnosed at adulthood. They are of major clinical importance as they are known predisposing factors for biliary carcinogenesis.Case presentationThe current report describes a patient with a simultaneous diagnosis of choledochal cyst and intracholecystic papillary-tubular neoplasm. The patient underwent excision of the extrahepatic biliary tree for a Todani I choledochal cyst, and histological examination of the specimen revealed an intracholecystic papillary-tubular neoplasm of the gallbladder. Authors describe diagnostic and clinical course of the patient alongside clinical and biological characteristics of these rare lesions.ConclusionsTo the best of our knowledge, this is the first report of a patient with a simultaneous diagnosis of choledochal cyst and intracholecystic papillary-tubular neoplasm. Those rare lesions shed light on different forms of gallbladder cancer carcinogenesis and its relationship with choledochal cysts and cholestasis.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intracholecystic papillary-tubular neoplasm in a patient with choledochal cyst: a link between choledochal cyst and gallbladder cancer?

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Before that, Duarte et al . completely blocked 162 gallbladders, but focused on dysplasia and metaplasia, and only studied a Chilean population ‐ that is recognized to harbour a much higher incidence of gallbladder neoplasia . Therefore, this author remains unaware of any previous study of European populations that has systematically recorded the extent of different pathological findings (including inflammatory changes) at different sites of a non‐tumorous gallbladder.…”

mentioning

confidence: 99%