Neoplastic Fever

CHANG, JAE C.

doi:10.1001/archinte.1989.00390080014004

Arch Intern Med

1989

DOI: 10.1001/archinte.1989.00390080014004

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Neoplastic Fever

JAE C. CHANG¹

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1995

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Cited by 18 publications

References 28 publications

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Metastatic breast cancer presenting as fever, rash, and arthritis

Drenth

Kleijn

Mulder

et al. 1995

Cancer

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Background. Fever can be the presenting symptom of metastatic breast carcinoma, but the combination of fever, polyarthritis, and an erythematous rash as a paraneoplastic syndrome in breast carcinoma is very rare. Methods. The clinical course of a 49‐year‐old female with a history of ductal breast carcinoma who presented with fever of unknown origin, polyarthritis, and an erythematous rash is described. Moreover, cytokine measurements were performed. Results. Initially, despite extensive evaluation, a diagnosis could not be made. Six weeks after the onset of symptoms, a right axillary lymph node became palpable and the diagnosis of relapsing breast carcinoma was made. Chemotherapy led to defervescence and disappearance of the symptoms. Elevated interleukin‐6 and interleukin‐1 receptor antagonist concentrations were found. Conclusion. To the authors' knowledge, the severe paraneoplastic signs encountered in this patient have not been described in breast carcinoma. The presentation is even more remarkable in view of the relatively small visible tumor mass. Cancer 1995; 75:1608‐11.

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Metastatic breast cancer presenting as fever, rash, and arthritis

Drenth

Kleijn

Mulder

et al. 1995

Cancer

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Causes of fever and value of C-reactive protein and procalcitonin in differentiating infections from paraneoplastic fever.

Penel

Fournier

Clisant

et al. 2004

Support Care Cancer

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Neoplastic fever: a neglected paraneoplastic syndrome

Zell

Chang

2005

Support Care Cancer

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Neoplastic fever, a paraneoplastic syndrome caused by cancer itself, represents a diagnostic challenge for the clinician and is an important issue in supportive oncology. Timely recognition of this febrile condition by differentiating it from other cancer-associated fevers, such as infection and drug reaction, is essential for effective patient management. Although the pathophysiology of neoplastic fever is not well understood, it is suspected to be cytokine mediated. In clinical practice, when a patient with cancer presents with unexplained fever, extensive diagnostic studies are needed to differentiate neoplastic fever from nonneoplastic fever. Only after excluding identifiable etiologies of fever can the diagnosis of neoplastic fever be suspected. According to our experience, the naproxen test is a safe and useful test in differentiating neoplastic fever from infectious fever in patients with cancer. In addition, naproxen and other nonsteroidal anti-inflammatory drugs have been effective in the management of neoplastic fever and offer a significant palliative benefit for the patient.

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Neoplastic Fever

Cited by 18 publications

References 28 publications

Metastatic breast cancer presenting as fever, rash, and arthritis

Metastatic breast cancer presenting as fever, rash, and arthritis

Causes of fever and value of C-reactive protein and procalcitonin in differentiating infections from paraneoplastic fever.

Neoplastic fever: a neglected paraneoplastic syndrome

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