A 16-year-old female Vietnamese pot-bellied pig was euthanized after a period of inappetence and weight loss. Diffuse cystic endometrial hyperplasia and endometrial adenocarcinoma with metastasis to lymph nodes, liver, and lung were diagnosed. This report follows the recent description of cystic endometrial hyperplasia and uterine leiomyomas in 3 aged female Vietnamese pot-bellied pigs. The findings in this report and previous reports suggest that pigs may develop some similar age-related uterine lesions as do women.