Neoplastic Disease

Boorman, Gary A.; Everitt, Jeffrey I.

doi:10.1016/b978-012074903-4/50017-0

Cited by 11 publications

(23 citation statements)

References 161 publications

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“…Stock-and strain-specific differences in the prevalence of some types of tumors are well documented (Boorman and Everitt, 2006). Stock-and strain-specific differences in the prevalence of some types of tumors are well documented (Boorman and Everitt, 2006).…”

Section: Neoplastic Diseasesmentioning

confidence: 99%

“…Among the environmental influences, diet has long been known to be an important factor in modulating tumor prevalence (Boorman and Everitt, 2006). Dietary factors may include manipulations of dietary composition (Rogers et al, 1993) such as high fat (Eustis and Boorman, 1985), specific amino acid deficiencies (Nakae, 1999), or even high protein levels.…”

Section: Laboratory Animal Medicinementioning

confidence: 99%

“…Data on tumor risk can be significantly influenced by the effect that some infectious diseases may have on longevity, pre-neoplastic or neoplastic changes, and masking of small tumors (Boorman and Everitt, 2006). Data on tumor risk can be significantly influenced by the effect that some infectious diseases may have on longevity, pre-neoplastic or neoplastic changes, and masking of small tumors (Boorman and Everitt, 2006).…”

Section: Laboratory Animal Medicinementioning

confidence: 99%

See 2 more Smart Citations

Biology and Diseases of Rats

Otto

Franklin

Clifford

2015

Laboratory Animal Medicine

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Section: Neoplastic Diseasesmentioning

confidence: 99%

Section: Laboratory Animal Medicinementioning

confidence: 99%

Section: Laboratory Animal Medicinementioning

confidence: 99%

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Biology and Diseases of Rats

Otto

Franklin

Clifford

2015

Laboratory Animal Medicine

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“…7,19,29,31,[33][34][35]46 We also consider the mixed cellular pattern and predominantly pulmonary distribution of the lymphoma type most frequently diagnosed in these bioassays to be uncharacteristic of lymphoma in rats (http://www.toxpath.org/ssdnc/ HemolyphaticProliferativeR.pdf). 6,[11][12][13][14]23,32,44,45 For these reasons, we consider it likely that these bioassays were confounded by M. pulmonis disease and suggest that a plausible alternative explanation for the reported results is that M. pulmonis disease interfered with accurate diagnosis and that lesions of the disease were interpreted as lymphoma.…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

Mycoplasma pulmonis and Lymphoma in Bioassays in Rats

et al. 2009

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Abstract. Lymphomas were reported to be induced in rats in bioassays of aspartame, methyltertiary-butyl ether (MTBE), and other chemicals conducted by a nonprofit cancer research organization. European regulatory authorities concluded that lymphomas in the aspartame study were caused by Mycoplasma pulmonis and suggested that this also was the case for the MTBE bioassay. To assess the role of M. pulmonis in these bioassays, we reviewed the tumor data for the aspartame and MTBE bioassays and, additionally, the organization's bioassay of methanol. For all 3 studies, the most frequently reported hematopoietic neoplasm was lympho-immunoblastic lymphoma, the most frequently affected organ was the lung, and, in almost half of the rats with this diagnosis, the lung was the only affected organ. Lesions diagnosed as lymphoma in published illustrations had pleomorphic cellular morphology and appeared to contain neutrophils. Information from these reports and other sources indicated that lesions typical of M. pulmonis disease were prevalent among the aspartame and MTBE study rats and that the rats were not specific-pathogen-free. Because the lymphoma type, cellular morphology, and organ distribution reported in these studies are atypical of lymphoma in rats, because lymphocyte and plasma cell accumulation in the lung is characteristic of M. pulmonis disease, and because M. pulmonis disease can be exacerbated by experimental manipulations, including chemical treatment, we suggest that a plausible alternative explanation for the reported results of these bioassays is that the studies were confounded by M. pulmonis disease and that lesions of the disease were interpreted as lymphoma.

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“…From the published reports and the data available online [Aspartame, 2007;Methyl-tertiary-butyl ether, 2007], the predominant form of lymphoma reported in these studies is ''lympho-immunoblastic,'' the organ most frequently affected is the lung, and in many rats, the lung is the only organ affected. Other than lymphoma-like lesions of uncertain nature reported only in association with M. pulmonis disease, no form of lymphoma in rats has such an organ distribution [Thompson et al, 1961;Prejean et al, 1973;Frith, 1988;Harleman and Jahn, 1990;Ward et al, 1990;Chandra et al, 1992;McMartin et al, 1992;Frith et al, 1996;Boorman and Everitt, 2006;Greaves, 2007)]. Lympho-immunoblastic lymphoma also is not a recognized lymphoma type in rats.…”

mentioning

confidence: 99%