Neoplastic diathesis of patients with carcinoid. Report of a case with four other neoplasms

Brown, Norman K.; Smith, Meredith P.

doi:10.1002/1097-0142(197307)32:1<216::aid-cncr2820320132>3.0.co;2-5

Cited by 28 publications

(3 citation statements)

References 19 publications

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“…3 This is thought to be due to a combination of: genetic predisposition, failure of immunological surveillance and skewed observations reflecting the indolent growth pattern of carcinoid tumours. 3,4 However, while there would appear to be anecdotal evidence, this is the first reported case in the literature of adenocarcinoma of the lung occurring simultaneously with a carcinoid tumour outside of the lung.…”

Section: Discussionmentioning

confidence: 80%

Primary adenocarcinoma of the lung with a synchronous carcinoid tumour of the small intestine

2013

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Section: Discussionmentioning

confidence: 80%

Primary adenocarcinoma of the lung with a synchronous carcinoid tumour of the small intestine

2013

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“…Our case report adds to the meager database of published literature available on this condition. The likely explanations for increase in synchronous neoplasm include genetic predisposition, growth stimulation induced by neuroendocrine factors secreted by carcinoids, failure of immunological surveillance and skewed observations reflecting the indolent growth pattern of carcinoid tumors [4, 5]. In patients diagnosed with adenocarcinoma of the colon and rectum, synchronous carcinoids could be missed due to their submucosal location, multicentricity and indolent growth pattern.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Adenocarcinoma of the Colon and Rectal Carcinoid

Vootla

Ahmed

Niazi

et al. 2016

Case Rep Gastroenterol

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Primary colonic adenocarcinoma and synchronous rectal carcinoids are rare tumors. Whenever a synchronous tumor with a nonmetastatic carcinoid component is encountered, its prognosis is determined by the associate malignancy. The discovery of an asymptomatic gastrointestinal carcinoid during the operative treatment of another malignancy will usually only require resection without additional treatment and will have little effect on the prognosis of the individual. This article reports a synchronous rectal carcinoid in a patient with hepatic flexure adenocarcinoma. We present a case of a 46-year-old Hispanic woman with a history of hypothyroidism, uterine fibroids and hypercholesterolemia presenting with a 2-week history of intermittent abdominal pain, mainly in the right upper quadrant. She had no family history of cancers. Physical examination was significant for pallor. Laboratory findings showed microcytic anemia with a hemoglobin of 6.6 g/dl. CT abdomen showed circumferential wall thickening in the ascending colon near the hepatic flexure and pulmonary nodules. Colonoscopy showed hepatic flexure mass and rectal nodule which were biopsied. Pathology showed a moderately differentiated invasive adenocarcinoma of the colon (hepatic flexure mass) and a low-grade neuroendocrine neoplasm (carcinoid of rectum). The patient underwent laparoscopic right hemicolectomy and chemotherapy. In patients diagnosed with adenocarcinoma of the colon and rectum, carcinoids could be missed due to their submucosal location, multicentricity and indolent growth pattern. Studies suggest a closer surveillance of the GI tract for noncarcinoid synchronous malignancy when a carcinoid tumor is detected and vice versa.

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“…The incidence of synchronous ileal carcinoids in the presence of primary colonic tumours is reported as 1-8% in the literature [1,2]. The synchronous and metachronous midgut carcinoid tumours are usually detected on staging evaluation, surgical exploration, histological examination and autopsies performed for the primary colonic tumours [3,4] The optimum imaging modality depends on whether it is used for detection of primary tumour or for the assessment of the metastasis. Quite contrary to our case, the most midgut carcinoid tumours are not visible on a CT scan, nevertheless the staging CT scan may reveal the presence of lymph nodes enlarged with metastasis from carcinoid cancers [5].…”

Section: Discussionmentioning

confidence: 99%

Synchronous ileal carcinoid and primary colonic neoplasms: a case report

Aslam

Salha

Muller

et al. 2009

Cases J

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Primary colonic tumours with synchronous ileal carcinoid tumours are rare in occurrence and are mainly found incidentally on autopsies or pathological examination of resected surgical specimens. This article describes a case of adenomatous colonic polyps, adenocarcinoma of sigmoid colon and concurrent malignant carcinoid tumour of ileocaecal junction, detected on colonoscopic examination. The radiological staging investigations revealed no distant spread of disease. The patient was effectively treated with subtotal colectomy, resection of terminal ileum, excision of locoregional lymph nodes and the bowel continuity was restored with stapled ileo-rectal anastomosis. This article is as an example of concomitant presence of two types of malignant tumours, effectively managed surgically.

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Neoplastic diathesis of patients with carcinoid. Report of a case with four other neoplasms

Cited by 28 publications

References 19 publications

Primary adenocarcinoma of the lung with a synchronous carcinoid tumour of the small intestine

Primary adenocarcinoma of the lung with a synchronous carcinoid tumour of the small intestine

Synchronous Adenocarcinoma of the Colon and Rectal Carcinoid

Synchronous ileal carcinoid and primary colonic neoplasms: a case report

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