Neoplastic Cerebral Aneurysm From Metastatic Nonsmall Cell Lung Carcinoma: Case Report and Literature Review

Omofoye, Oluwaseun A.; Barnett, Randaline; Lau, Winnie; Trembath, Dimitri G.; Jordan, J. Dedrick; Sasaki‐Adams, Deanna

doi:10.1093/neuros/nyx588

Cited by 15 publications

(5 citation statements)

References 15 publications

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“…Nussbaum et al reported a case of multiple new intracranial aneurysms 4 months after treatment for an NCA due to breast cancer, 3 ) whereas Omofoye et al reported a case of SAH due to a ruptured de novo left superior cerebellar aneurysm not found on magnetic resonance angiography 19 days earlier in a patient with non-small cell lung cancer. 7 ) Moreover, the present case had a short development time of 33 days, demonstrating the possibility of aneurysm formation and rupture in a short time in NCAs associated with malignancy. In the present case, a minor leak of the SAH was observed at the routine follow-up CT on day 30, but the CTA did not include the parietal area, and the aneurysm could not be detected at that time.…”

Section: Discussionmentioning

confidence: 50%

A Case of Multiple Intracranial Hemorrhages due to a Ruptured Neoplastic Cerebral Aneurysm Secondary to Metastasis of Poorly Differentiated Parotid Gland Carcinoma

IRIZATO,

FUKUYA,

NAKATA

et al. 2024

NMC Case Report Journal

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Section: Discussionmentioning

confidence: 50%

A Case of Multiple Intracranial Hemorrhages due to a Ruptured Neoplastic Cerebral Aneurysm Secondary to Metastasis of Poorly Differentiated Parotid Gland Carcinoma

IRIZATO,

FUKUYA,

NAKATA

et al. 2024

NMC Case Report Journal

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“…It is reported that the biological features of the primary tumour are involved in the development and prognosis of the aneurysm; in particular, it seems that the diffusion of tumour cells to the brain can damage vessel walls promoting aneurysm formation. In addition, it is assumed that the gravity of damage depends on the grade of malignancy of the neoplastic cells: data reports that IAs associated with benign tumours are less prone to rupture and cause intracranial haemorrhage than IAs associated with malign tumours [9][10][11]. Neoplastic IAs are mainly associated with metastatic cardiac myxomas and choriocarcinoma, and less frequently with other metastatic tumours such as lymphoma, cardiac myxosarcoma and lung cancer [9,10,12].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Incidental Intracranial Aneurysms in Oncologic Patients

Imperato

Capasso

Cataldo

et al. 2021

SN Compr. Clin. Med.

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The purpose of this retrospective study is to evaluate the prevalence and the imaging features of incidental intracranial aneurysms (IAs) in oncologic patients. We retrospectively examined 6599 brain CT studies performed for cancer staging (without and with intravenous iodinated contrast medium) at our institution, between January 2016 and December 2019. Subsequently, we selected only CT studies that revealed the presence of intracranial aneurysms as incidental findings; then, we recorded patients' age and sex, primary tumour location and intracranial aneurysms position and size. Finally, the prevalence of intracranial aneurysms in this oncologic population was calculated. We found 60 intracranial aneurysms in 53 patients with a prevalence of 0.9%. There were 18 women and 35 men with a mean age of 67 years. Patients older than 65 years represented 64% of our study population. Aneurysm dimensions ranged between 2 and 43 mm, there was a giant aneurysm and 80% of aneurysms were smaller than 10 mm. The main localization was the right middle cerebral artery followed by the anterior communicating artery. Moreover, we observed mirror aneurysms originating from the middle cerebral arteries in three patients and from the carotid-ophthalmic artery junctions in one patient. The recent diffusion and better performance of imaging techniques led us to easier recognition of incidental intracranial aneurysms during brain CT examinations performed for cancer staging. Early detection of these vascular lesions allows for immediate radiologic evaluation and may improve patient management.

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“…Neoplastic etiology of intracranial cerebral aneurysm formation is rare 1,2 . Yet, some authors indicate that the risk of its development is higher in malignant tumor patients who receive radiation therapy (RT), particularly in those with a history of high radiation dose exposure to intracranial vessels 3 .…”

Section: Introductionmentioning

confidence: 99%

The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review

Rotim

Splavski

Trkanjec

et al. 2020

ACC

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-Neoplastic etiology of intracranial cerebral aneurysm is rare. Yet, the risk of its development is higher in malignant tumor patients receiving radiation therapy. Due to the possible negative effects of irradiation on intracranial vessel walls, the risk of aneurysm formation after radiation therapy, which is crucial for some types of breast cancer patients, continues to be a matter of debate. The aim of this study was to evaluate the hazard of multiple intracranial aneurysm development in patients with malignant disease undergoing radiation therapy. It is based on literature review and case report of a 77-year-old female patient who underwent surgery for multifocal invasive hormone-receptor positive ductal breast carcinoma of no special type, followed by chemotherapy, adjuvant radiation and hormone therapy. Her comorbidity included arterial hypertension and type 2 diabetes. Six unruptured intracranial aneurysms of different bilateral locations were diagnosed incidentally by multi-slice computed tomography angiography and digital subtraction angiography of cerebral vessels. Due to the bilateral aneurysm multiplicity, tumor characteristics and prognosis, comorbidity and relatively advanced age, the patient was not selected for active endovascular or microsurgical aneurysm treatment but only periodical clinical, oncologic and radiological follow-up was advised. In conclusion, the risk of multiple intracranial aneurysm formation in patients with breast cancer undergoing radiation therapy is low, but still possible. Long-term follow-up and regular cerebral angiographic checkup studies are necessary in selected malignant patients to decrease such a risk and to evade the worst outcome associated with aneurysm rupture.

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Neoplastic Cerebral Aneurysm From Metastatic Nonsmall Cell Lung Carcinoma: Case Report and Literature Review

Cited by 15 publications

References 15 publications

A Case of Multiple Intracranial Hemorrhages due to a Ruptured Neoplastic Cerebral Aneurysm Secondary to Metastasis of Poorly Differentiated Parotid Gland Carcinoma

A Case of Multiple Intracranial Hemorrhages due to a Ruptured Neoplastic Cerebral Aneurysm Secondary to Metastasis of Poorly Differentiated Parotid Gland Carcinoma

Prevalence of Incidental Intracranial Aneurysms in Oncologic Patients

The Risk of Multiple Intracranial Aneurysm Formation in Patients with Malignant Disease Undergoing Radiation Therapy: a Case Report and Literature Review

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